The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

HSF1 phase transition mediates stress adaptation and cell fate decisions

(2020) Giorgio Gaglia et al.   NATURE CELL BIOLOGY

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mutant p53R175H promotes cancer initiation in the pancreas by stabilizing HSP70

(2019) Kishore Polireddy et al.   CANCER LETTERS

Change in neutrophil to lymphocyte ratio during immunotherapy treatment is a non-linear predictor of patient outcomes in advanced cancers

(2019) Mingjia Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Dual inhibition of the PI3K and MAPK pathways enhances nab-paclitaxel/gemcitabine chemotherapy response in preclinical models of pancreatic cancer

(2019) Niranjan Awasthi et al.   CANCER LETTERS

Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-Cohort Study in Denmark

(2018) Jakob Kirkegård et al.   GASTROENTEROLOGY

Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion

(2018) Shin Kibe et al.   CANCER LETTERS

Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

(2017) Wenjin Liang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

“Heat shock protein 70 in pancreatic diseases: Friend or foe”

(2017) Bhuwan Giri et al.   JOURNAL OF SURGICAL ONCOLOGY

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

(2017) Ke Chen et al.   Molecular Cancer

Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway

(2017) Ke Chen et al.   Molecular Oncology

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

(2017) Peter Storz   Nature Reviews Gastroenterology & Hepatology

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

(2017) H Zhou et al.   ONCOGENE

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

Modifiable and non-modifiable risk factors for pancreatic cancer: A review

(2016) Shallu Midha et al.   CANCER LETTERS

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01)

(2016) Katsuhiko Uesaka et al.   LANCET

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

KRAS-related proteins in pancreatic cancer

(2016) Karen M. Mann et al.   PHARMACOLOGY & THERAPEUTICS

HSF1: Guardian of Proteostasis in Cancer

(2016) Chengkai Dai et al.   TRENDS IN CELL BIOLOGY

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

(2015) Zijian Tang et al.   CELL

The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis

(2015) Kristoffer R. Brandvold et al.   JOURNAL OF MOLECULAR BIOLOGY

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

(2015) Nikos Kourtis et al.   NATURE CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α

(2015) Neri Minsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

(2015) S N Payne et al.   Oncogenesis

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

Co-Treatment with Panitumumab and Trastuzumab Augments Response to the MEK Inhibitor Trametinib in a Patient-Derived Xenograft Model of Pancreatic Cancer

(2014) James M. Lindberg et al.   NEOPLASIA

The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models

(2013) Ruizhe Shen et al.   CANCER LETTERS

Chronic pancreatitis: A path to pancreatic cancer

(2013) Andreia V. Pinho et al.   CANCER LETTERS

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

(2013) Meredith A. Collins et al.   GASTROENTEROLOGY

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

(2012) Chengkai Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition

(2012) Oliver Weigert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

(2011) Thomas De Raedt et al.   CANCER CELL

Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic Syndrome

(2011) Xiongjie Jin et al.   Cell Metabolism

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability

(2010) Shu-Bing Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL