Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

(2016) Daoyan Wei et al.   CANCER CELL

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

(2016) C. Benedikt Westphalen et al.   Cell Stem Cell

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells

(2016) Jun Liu et al.   Scientific Reports

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

NFATc4 RegulatesSox9Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

(2016) Elisabeth Hessmann et al.   Stem Cells International

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Pdx1 regulates pancreas tubulogenesis and E-cadherin expression

(2015) Leilani Marty-Santos et al.   DEVELOPMENT

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas

(2015) Audrey M. Hendley et al.   DEVELOPMENTAL BIOLOGY

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas

(2015) Nai-Ming Chen et al.   GASTROENTEROLOGY

The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice

(2015) Paola Martinelli et al.   GUT

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

(2015) SangWun Kim et al.   PANCREAS

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

(2015) Alessandra Rosati et al.   Nature Communications

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

(2015) Geou-Yarh Liou et al.   Nature Communications

Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice

(2015) Shinichi Hosokawa et al.   Scientific Reports

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

(2015) S N Payne et al.   Oncogenesis

Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression

(2015) Toya M. Albury et al.   NEOPLASIA

Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells

(2015) Dongfeng Qu et al.   PLoS One

Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis

(2015) Anju Karki et al.   PLoS One

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia

(2015) Parama Dey et al.   Oncotarget

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice

(2014) Patrick C. Hermann et al.   GASTROENTEROLOGY

PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice

(2014) Chia-Yen C. Wu et al.   GASTROENTEROLOGY

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

(2014) Romain Baer et al.   GENES & DEVELOPMENT

SOX9 regulates ERBB signalling in pancreatic cancer development

(2014) Adrien Grimont et al.   GUT

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p21WAF1/Cip1limits senescence and acinar-to-ductal metaplasia formation during pancreatitis

(2014) Kamile Grabliauskaite et al.   JOURNAL OF PATHOLOGY

Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation

(2014) John P. Morris et al.   PLoS One

Dicer Is Required for Maintenance of Adult Pancreatic Acinar Cell Identity and Plays a Role in Kras-Driven Pancreatic Neoplasia

(2014) Yue J. Wang et al.   PLoS One

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

(2013) M. Luisa Campos et al.   BIOCHEMICAL JOURNAL

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression

(2013) Vindhya Palagani et al.   CARCINOGENESIS

Numb Regulates Acinar Cell Dedifferentiation and Survival During Pancreatic Damage and Acinar-to-Ductal Metaplasia

(2013) Renee L. Greer et al.   GASTROENTEROLOGY

Control of Cell Identity in Pancreas Development and Regeneration

(2013) Ben Z. Stanger et al.   GASTROENTEROLOGY

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors

(2013) Kathleen E. DelGiorno et al.   GASTROENTEROLOGY

Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

(2013) Andrew D. Rhim et al.   GASTROENTEROLOGY

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

(2013) Meredith A. Collins et al.   GASTROENTEROLOGY

Nr5a2heterozygosity sensitises to, and cooperates with, inflammation inKRasG12V-driven pancreatic tumourigenesis

(2013) Marta Flandez et al.   GUT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms

(2013) Stuti Shroff et al.   HUMAN PATHOLOGY

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

Oncogenic K-Ras requires activation for enhanced activity

(2013) H Huang et al.   ONCOGENE

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

(2013) Masao Tanaka et al.   PANCREATOLOGY

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Induced Mist1 Expression Promotes Remodeling of Mouse Pancreatic Acinar Cells

(2012) Daniel Direnzo et al.   GASTROENTEROLOGY

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

(2012) Pierre-Paul Prévot et al.   GUT

Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1

(2012) Charis L Johnson et al.   JOURNAL OF PATHOLOGY

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia

(2012) G Shi et al.   ONCOGENE

Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma

(2012) Jacqueline L. Avila et al.   PLoS One

sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development

(2012) Marion Delous et al.   PLoS Genetics

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer

(2011) Irina Heid et al.   GASTROENTEROLOGY

Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas

(2011) Isabelle Houbracken et al.   GASTROENTEROLOGY

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

(2011) Ilse Rooman et al.   GUT

Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents

(2011) Paul J. Grippo et al.   INTERNATIONAL JOURNAL OF CANCER

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues

(2011) Michaela Aichler et al.   JOURNAL OF PATHOLOGY

Acute Pancreatitis Accelerates Initiation and Progression to Pancreatic Cancer in Mice Expressing Oncogenic Kras in the Nestin Cell Lineage

(2011) Catherine Carrière et al.   PLoS One

Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms

(2011) Jason Y. Park et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer

(2010) Alfonso Sánchez-Muñoz et al.   BMC CANCER

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells

(2010) Toshihiko Masui et al.   GASTROENTEROLOGY

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Ras Activity in Acinar Cells Links Chronic Pancreatitis and Pancreatic Cancer

(2009) Craig D. Logsdon et al.   Clinical Gastroenterology and Hepatology

Ras Activity Levels Control the Development of Pancreatic Diseases

(2009) Baoan Ji et al.   GASTROENTEROLOGY

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice

(2009) Jennifer M. Oliver-Krasinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic Ductal Morphogenesis and the Pdx1 Homeodomain Transcription Factor

(2009) Melanie P. Wescott et al.   MOLECULAR BIOLOGY OF THE CELL

KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

(2009) C. Shi et al.   MOLECULAR CANCER RESEARCH

Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer

(2008) Carolyn E. Clark et al.   CANCER LETTERS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

(2008) Volker Fendrich et al.   GASTROENTEROLOGY

Mist1 Regulates Pancreatic Acinar Cell Proliferation Through p21CIP1/WAF1

(2008) Di Jia et al.   GASTROENTEROLOGY

Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling

(2008) Lynda Elghazi et al.   GASTROENTEROLOGY

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

(2008) N. Habbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA