BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2

Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility

(2020) Federica Barbagallo et al.   Journal of Clinical Medicine

The environment as a determinant of successful aging or frailty

(2020) Agostino Di Ciaula et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways

(2019) Huaying Fan et al.   PHYTOMEDICINE

Mechanisms of ROS-induced mitochondria-dependent apoptosis underlying liquid storage of goat spermatozoa

(2019) Tengfei Liu et al.   Aging-US

Sperm mitochondrial regulation in motility and fertility in horses

(2019) Stuart Meyers et al.   REPRODUCTION IN DOMESTIC ANIMALS

Comparative analysis of mammalian sperm ultrastructure reveals relationships between sperm morphology, mitochondrial functions and motility

(2019) Ni-Hao Gu et al.   Reproductive Biology and Endocrinology

Icariin protects mouse Leydig cell testosterone synthesis from the adverse effects of di(2-ethylhexyl) phthalate

(2019) Jiandong Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

(2019) Xiao Gao et al.   Stem Cell Reports

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

(2019) Lin Li et al.   Aging-US

Imperatorin improves in vitro porcine embryo development by reducing oxidative stress and autophagy

(2019) Dan Luo et al.   THERIOGENOLOGY

A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters

(2019) Mingpeng Zhao et al.   Trials

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model

(2019) Malsawmhriatzuala Jeremy et al.   Scientific Reports

Chlorogenic acid improves the quality of boar semen subjected to cooled storage at 15°C

(2018) B. A. Pereira et al.   ANDROLOGIA

Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells

(2018) Yung Hyun Choi   BIOMEDICINE & PHARMACOTHERAPY

Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition

(2018) Yibo Li et al.   CELL CYCLE

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

(2018) Carla Tatone et al.   HUMAN REPRODUCTION UPDATE

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

(2018) Irene Santos-Barriopedro et al.   Nature Communications

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

(2018) Shrestha Ghosh et al.   eLife

Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice

(2018) Gurjit Singh et al.   INFLAMMOPHARMACOLOGY

Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

(2018) Gesine Reichart et al.   Acta Physiologica

Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells

(2018) Huimin Hu et al.   INFLAMMATION

Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

(2018) Chenyue Liu et al.   Frontiers in Pharmacology

Pro-steroidogenic and pro-spermatogenic actions of nitric oxide (NO) on the catfish, Clarias batrachus: An in vivo study

(2017) Vinay Kumar Singh et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Thymoquinone Defeats Diabetes-Induced Testicular Damage in Rats Targeting Antioxidant, Inflammatory and Aromatase Expression

(2017) Mustafa Atta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Outer dense fibers stabilize the axoneme to maintain sperm motility

(2017) Wenlong Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D -galactose /NaNO 2

(2017) Peipei Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Impaired hypothalamic-pituitary-testicular axis activity, spermatogenesis, and sperm function promote infertility in males with lead poisoning

(2017) Jason Gandhi et al.   ZYGOTE

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53

(2017) Harumasa Nakazawa et al.   PLoS One

Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway

(2017) Ying Guo et al.   Scientific Reports

Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes

(2016) María Eugenia Matzkin et al.   Aging-US

Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice

(2016) Zhi-Jun Zang et al.   ASIAN JOURNAL OF ANDROLOGY

Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway

(2016) Jingbo Chen et al.   BMC Complementary and Alternative Medicine

Sirtuins: Novel Players in Male Reproductive Health

(2016) Luís Rato et al.   CURRENT MEDICINAL CHEMISTRY

Enclomiphene citrate for the treatment of secondary male hypogonadism

(2016) Katherine M. Rodriguez et al.   EXPERT OPINION ON PHARMACOTHERAPY

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(2016) Michael Van Meter et al.   Cell Reports

Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats

(2014) A.-M. Joseph et al.   BIOGERONTOLOGY

Hippocampal Neurochemical Changes in Senescent Mice Induced with Chronic Injection of D-Galactose and NaNO2: An In Vitro High-Resolution NMR Spectroscopy Study at 9.4T

(2014) Yan Lin et al.   PLoS One

Microtubules and spermatogenesis

(2014) Liza O’Donnell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prooxidant Effects of Verbascoside, a Bioactive Compound from Olive Oil Mill Wastewater, onIn VitroDevelopmental Potential of Ovine Prepubertal Oocytes and Bioenergetic/Oxidative Stress Parameters of Fresh and Vitrified Oocytes

(2014) M. E. Dell'Aquila et al.   Biomed Research International

The Spermatogenic Effect of Yacon Extract and Its Constituents and Their Inhibition Effect of Testosterone Metabolism

(2013) Jeong Sook Park et al.   Biomolecules & Therapeutics

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity

(2011) Nicole O. Palmer et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptis fasciculata

(2009) C.G. Silva et al.   PHYTOMEDICINE

Free Radical Theory of Aging: Implications in Male Infertility

(2009) Nisarg Desai et al.   UROLOGY

Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

(2008) Sandra Amaral et al.   FEBS LETTERS