Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle

(2017) Jan Niemann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

(2017) Xianghui Zou et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Bioenergetic roles of mitochondrial fusion

(2016) Eduardo Silva Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice

(2016) Christin Kretzschmar et al.   EXPERIMENTAL HEMATOLOGY

Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells

(2016) CATRIN ROOLF et al.   IN VIVO

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Uncoupling protein 2 protects mice from aging

(2016) Misa Hirose et al.   MITOCHONDRION

Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes

(2016) Amita Daverey et al.   NEUROSCIENCE

Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

(2016) Christin Kretzschmar et al.   Oncotarget

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease

(2016) Sugako Oka et al.   Scientific Reports

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Generating Neuronal Diversity in the Mammalian Cerebral Cortex

(2015) Simona Lodato et al.   Annual Review of Cell and Developmental Biology

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Mitochondrial Diseases Part I: Mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors

(2015) Alessandra Torraco et al.   MITOCHONDRION

A novel m.7539C>T point mutation in the mt-tRNAAsp gene associated with multisystemic mitochondrial disease

(2015) Diana Lehmann et al.   NEUROMUSCULAR DISORDERS

Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants

(2015) Johannes Mayer et al.   PLoS One

Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

(2014) Sumit Parikh et al.   GENETICS IN MEDICINE

Molecular Findings Among Patients Referred for Clinical Whole-Exome Sequencing

(2014) Yaping Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

(2014) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternally transmitted mitochondrial DNA mutations can reduce lifespan

(2014) Jaime M. Ross et al.   Scientific Reports

Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision

(2013) Macarena Gil-Pagés et al.   Behavioral and Brain Functions

Disease progression in patients with single, large-scale mitochondrial DNA deletions

(2013) J. P. Grady et al.   BRAIN

Mitochondrial–Nuclear Interactions: Compensatory Evolution or Variable Functional Constraint among Vertebrate Oxidative Phosphorylation Genes?

(2013) Feifei Zhang et al.   Genome Biology and Evolution

The role of mitochondrial DNA mutations and free radicals in disease and ageing

(2013) M. Lagouge et al.   JOURNAL OF INTERNAL MEDICINE

Neocortex and Allocortex Respond Differentially to Cellular Stress In Vitro and Aging In Vivo

(2013) Jessica M. Posimo et al.   PLoS One

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Cognitive dysfunction in mitochondrial disorders

(2012) J. Finsterer   ACTA NEUROLOGICA SCANDINAVICA

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

A novel mitochondrial tRNA Arg mutation resulting in an anticodon swap in a patient with mitochondrial encephalomyopathy

(2012) Sara Roos et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions

(2012) Francisca Diaz et al.   HUMAN MOLECULAR GENETICS

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

Cytokines induced by long-term potentiation (LTP) recording: A potential explanation for the lack of correspondence between learning/memory performance and LTP

(2012) Y. Huang et al.   NEUROSCIENCE

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

(2011) Ashok Kumar   Frontiers in Aging Neuroscience

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

(2011) Raquel Moreno-Loshuertos et al.   PLoS Genetics

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Mitochondrial tRNA mutations and disease

(2010) John W. Yarham et al.   Wiley Interdisciplinary Reviews-RNA

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2

(2009) Hua Yang et al.   HUMAN MOLECULAR GENETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains

(2008) X. Yu et al.   GENOME RESEARCH

Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse

(2008) Paweł Sachadyn et al.   MITOCHONDRION

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One