The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

Novel strategies to target PCSK9: beyond monoclonal antibodies

(2019) Nabil G Seidah et al.   CARDIOVASCULAR RESEARCH

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

(2018) Paul Lebeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Atherosclerosis: Should we redefine the 'normal' LDL-cholesterol range?

(2018) Irene Fernández-Ruiz   Nature Reviews Cardiology

Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death

(2018) Paul Lebeau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage

(2018) Cheng-Chieh Fang et al.   Scientific Reports

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype

(2017) John S. Chorba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipids: Very low achieved LDL-cholesterol levels improve cardiovascular outcomes

(2017) Karina Huynh   Nature Reviews Cardiology

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

(2017) Yumei Xiong et al.   Science Translational Medicine

GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition

(2017) Jiaying Lin et al.   NEOPLASIA

Endoplasmic Reticulum Stress and Ca2+Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism

(2016) Paul Lebeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis

(2016) Manish K. Gupta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

(2016) Michel Chrétien et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PCSK9 inhibitors in the prevention of cardiovascular disease

(2016) James Latimer et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Focus on PCSK9 Inhibitors: From Genetics to Clinical Practice

(2016) Marc S. Sabatine et al.   POSTGRADUATE MEDICINE

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.

(2015) Ali A. Al-Hashimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation

(2015) Steve Poirier et al.   Cell Reports

The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis

(2014) John S. Chorba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis

(2013) Wan-Ting Chen et al.   HEPATOLOGY

The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells

(2013) Xiu-Xiu Zhang et al.   Biomed Research International

Loss- and Gain-of-function PCSK9 Variants

(2012) Suzanne Benjannet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture

(2011) J. Mayne et al.   CLINICAL CHEMISTRY

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress

(2011) Kaori Suyama et al.   NEUROSCIENCE LETTERS

Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores

(2010) Ali A. Al-Hashimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Mutation of the Mouse Grp94 Gene Disrupts Development and Perturbs Endoplasmic Reticulum Stress Signaling

(2010) Changhui Mao et al.   PLoS One

The Unfolded Protein Response in Health and Disease

(2009) Richard C. Austin   ANTIOXIDANTS & REDOX SIGNALING

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease

(2009) Marianne Abifadel et al.   HUMAN MUTATION

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE