Thymic epithelial cell development and differentiation: cellular and molecular regulation

The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells

(2014) N. Seach et al.   JOURNAL OF IMMUNOLOGY

Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation

(2014) J. Dooley et al.   JOURNAL OF IMMUNOLOGY

An Epithelial Progenitor Pool Regulates Thymus Growth

(2014) W. E. Jenkinson et al.   JOURNAL OF IMMUNOLOGY

Checkpoints in the Development of Thymic Cortical Epithelial Cells

(2014) S. Shakib et al.   JOURNAL OF IMMUNOLOGY

Lt r Signaling Does Not Regulate Aire-Dependent Transcripts in Medullary Thymic Epithelial Cells

(2014) V. C. Martins et al.   JOURNAL OF IMMUNOLOGY

AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH

(2012) Ingrid Liiv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a

(2012) B. Berent-Maoz et al.   BLOOD

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Differential processing of self-antigens by subsets of thymic stromal cells

(2012) Sylvie Guerder et al.   CURRENT OPINION IN IMMUNOLOGY

β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells

(2012) Yousuke Takahama et al.   CURRENT OPINION IN IMMUNOLOGY

Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis

(2012) J. R. Gardiner et al.   DEVELOPMENT

Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium

(2012) Natalie A. Roberts et al.   IMMUNITY

Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells

(2012) Claudia Macedo et al.   IMMUNOBIOLOGY

Expression profile of peripheral tissue antigen genes in medullary thymic epithelial cells (mTECs) is dependent on mRNA levels of autoimmune regulator (Aire)

(2012) Ernna H. Oliveira et al.   IMMUNOBIOLOGY

Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development

(2012) Konstantina Alexandropoulos et al.   IMMUNOLOGIC RESEARCH

MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection

(2012) S. Zuklys et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Cells Regulate Retinoic Acid Receptor-Dependent Cortical Thymic Epithelial Cell Homeostasis

(2012) K. M. Sitnik et al.   JOURNAL OF IMMUNOLOGY

Deletion of FoxN1 in the Thymic Medullary Epithelium Reduces Peripheral T Cell Responses to Infection and Mimics Changes of Aging

(2012) Jianfei Guo et al.   PLoS One

Regenerative capacity of adult cortical thymic epithelial cells

(2012) I. Rode et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors

(2011) K. M. Heinonen et al.   BLOOD

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

(2011) E. C. Zook et al.   BLOOD

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t

(2011) Adiratna Mat Ripen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy

(2011) A. Bravo-Nuevo et al.   INTERNATIONAL IMMUNOLOGY

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

(2011) Christophe Viret et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma

(2011) Y. Mouri et al.   JOURNAL OF IMMUNOLOGY

Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence

(2011) Zoltan Varecza et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway

(2011) Krista M. Heinonen et al.   PLoS One

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

(2011) M. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence

(2011) Gergely Talaber et al.   REJUVENATION RESEARCH

Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence

(2011) Craig S. Nowell et al.   PLoS Genetics

Models of Aire-Dependent Gene Regulation for Thymic Negative Selection

(2011) Dina Danso-Abeam et al.   Frontiers in Immunology

The complicated role of NF-κB in T-cell selection

(2010) Mingzhao Zhu et al.   Cellular & Molecular Immunology

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

(2010) Yumiko Nishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin

(2010) Nichole M. Danzl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tbatamodulates thymic stromal cell proliferation and thymus function

(2010) Francis A. Flomerfelt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

(2010) A. J. White et al.   JOURNAL OF IMMUNOLOGY

DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

(2010) Masako Osada et al.   PLoS One

Wnt4 and LAP2alpha as Pacemakers of Thymic Epithelial Senescence

(2010) Krisztian Kvell et al.   PLoS One

Deficiency of the Metalloproteinase-Disintegrin ADAM8 Is Associated with Thymic Hyper-Cellularity

(2010) Klaus Gossens et al.   PLoS One

ADAM17 Deletion in Thymic Epithelial Cells Alters Aire Expression without Affecting T Cell Developmental Progression

(2010) David M. Gravano et al.   PLoS One

Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage

(2010) T. Corbeaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct and indirect roles of the LTβR pathway in central tolerance induction

(2010) Mingzhao Zhu et al.   TRENDS IN IMMUNOLOGY

Aire

(2009) Diane Mathis et al.   Annual Review of Immunology

Foxn1 is essential for vascularization of the murine thymus anlage

(2009) Kazuya Mori et al.   CELLULAR IMMUNOLOGY

AIRE in the thymus and beyond

(2009) James M Gardner et al.   CURRENT OPINION IN IMMUNOLOGY

Thymus-specific serine protease regulates positive selection of a subset of CD4+thymocytes

(2009) Julien Gommeaux et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatial (Tbata) expression in mature medullary thymic epithelial cells

(2009) Murielle Saade et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy

(2009) Lili Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch activation in thymic epithelial cells induces development of thymic microenvironments

(2009) Kyoko Masuda et al.   MOLECULAR IMMUNOLOGY

Control of central self-tolerance induction by autoreactive CD4+ thymocytes

(2009) Magali Irla et al.   TRENDS IN IMMUNOLOGY

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

(2008) L. Chen et al.   BLOOD

Thymoproteasome: probable role in generating positively selecting peptides

(2008) Shigeo Murata et al.   CURRENT OPINION IN IMMUNOLOGY

Crosstalk via the NF-κB signaling system

(2008) Soumen Basak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

(2008) Magali Irla et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

(2008) Ute Koch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

(2008) Masashi Yano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

(2008) J. Derbinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA