Shear-Induced Amyloid Aggregation in the Brain: V. Are Alzheimer’s and Other Amyloid Diseases Initiated in the Lower Brain and Brainstem by Cerebrospinal Fluid Flow Stresses?

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

(2020) Jacob Jan Sloots et al.   NEUROIMAGE

The Toxicity and Polymorphism of β-Amyloid Oligomers

(2020) Ya-ru Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Local Sleep and Alzheimer’s Disease Pathophysiology

(2020) Bryce A. Mander   Frontiers in Neuroscience

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Getting to the Heart of Alzheimer Disease

(2019) Joshua M. Tublin et al.   CIRCULATION RESEARCH

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Synergistic effects of flow and interfaces on antibody aggregation

(2019) Fulvio Grigolato et al.   BIOTECHNOLOGY AND BIOENGINEERING

Preliminary Capillary Flow Experiments with Amyloid-β, Possible Needle and Capillary Aβ Adsorption, and a Proposal for Drug Evaluation Under Shear Conditions

(2019) Conrad N. Trumbore et al.   JOURNAL OF ALZHEIMERS DISEASE

Fluid dynamics of cerebrospinal fluid flow in perivascular spaces

(2019) John H. Thomas   Journal of the Royal Society Interface

Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

(2018) Nathalie Thorin-Trescases et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules

(2018) Leon F. Willis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Impact of Cavitation, High Shear Stress and Air/Liquid Interfaces on Protein Aggregation

(2018) Mark Duerkop et al.   Biotechnology Journal

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Shear-Induced Amyloid Formation in the Brain: III. The Roles of Shear Energy and Seeding in a Proposed Shear Model

(2018) Conrad N. Trumbore   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

(2018) Nunilo Cremades et al.   NEUROBIOLOGY OF DISEASE

Impact of Cavitation, High Shear Stress and Air/Liquid Interfaces on Protein Aggregation

(2018) Mark Duerkop et al.   Biotechnology Journal

Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

(2018) Matthew J. Betts et al.   Frontiers in Neuroscience

Shear-induced amyloid formation in the brain: IV. Effects on synapses surrounding senile plaque and in plaque-free regions

(2018) Conrad N. Trumbore   JOURNAL OF ALZHEIMERS DISEASE

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

(2018) Mathias Jucker et al.   NATURE NEUROSCIENCE

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology

(2017) Francis T. Hane et al.   JOURNAL OF ALZHEIMERS DISEASE

Shear-Induced Amyloid Formation in the Brain: II. An Experimental System for Monitoring Amyloid Shear Processes and Investigating Potential Spinal Tap Problems

(2017) Conrad N. Trumbore   JOURNAL OF ALZHEIMERS DISEASE

Magnetic resonance imaging of the human locus coeruleus: A systematic review

(2017) Kathy Y. Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inducing protein aggregation by extensional flow

(2017) John Dobson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Amyloid Phenomenon and Its Links with Human Disease

(2017) Christopher M. Dobson   Cold Spring Harbor Perspectives in Biology

The Neuroanatomy of the Reticular Nucleus Locus Coeruleus in Alzheimer’s Disease

(2017) Filippo S. Giorgi et al.   Frontiers in Neuroanatomy

A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces

(2017) Siddhartha Banerjee et al.   Scientific Reports

Magnetic Resonance Imaging Technique for Visualization of Irregular Cerebrospinal Fluid Motion in the Ventricular System and Subarachnoid Space

(2017) Tomohiko Horie et al.   World Neurosurgery

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity

(2017) Benedetta Mannini et al.   Frontiers in Molecular Neuroscience

Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases

(2016) Lary C. Walker   Annual Review of Genetics

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes

(2016) Conrad N. Trumbore   JOURNAL OF ALZHEIMERS DISEASE

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

(2015) Daniele Granata et al.   Scientific Reports

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

(2014) B. Siyahhan et al.   Journal of the Royal Society Interface

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

(2013) Daniel García-Lorenzo et al.   BRAIN

Arterial supply of the lower cranial nerves: A comprehensive review

(2013) Philipp Hendrix et al.   CLINICAL ANATOMY

Velocity and pressure gradients of cerebrospinal fluid assessed with magnetic resonance imaging

(2013) Mitsunori Matsumae et al.   JOURNAL OF NEUROSURGERY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

De novo generation of prion strains

(2011) David W. Colby et al.   NATURE REVIEWS MICROBIOLOGY

Effect of Surfaces on Amyloid Fibril Formation

(2011) Bradley Moores et al.   PLoS One

Susceptibility of Different Proteins to Flow-Induced Conformational Changes Monitored with Raman Spectroscopy

(2010) Lorna Ashton et al.   BIOPHYSICAL JOURNAL

Models of membrane-bound Alzheimer's Abeta peptide assemblies

(2010) Yinon Shafrir et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Shear flow promotes amyloid-  fibrilization

(2009) D. E. Dunstan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Hydrogen Tunneling in an Enzyme Active Site: A Quantum Wavepacket Dynamical Perspective

(2008) Srinivasan S. Iyengar et al.   JOURNAL OF PHYSICAL CHEMISTRY B