Inducing protein aggregation by extensional flow

A New Robust Estimator of Polydispersity from Dynamic Light Scattering Data

(2016) Valentin Roger et al.   ANALYTICAL CHEMISTRY

The Effect of Shear on the Structural Conformation of rhGH and IgG1 in Free Solution

(2016) Lukas Brückl et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microfluidic assessment of mechanical cell damage by extensional stress

(2016) Young Bok Bae et al.   LAB ON A CHIP

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

(2016) Claire L. Dobson et al.   Scientific Reports

Force-induced remodelling of proteins and their complexes

(2015) Yun Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

(2015) Kevin W. Tipping et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

(2015) Kevin W. Tipping et al.   TRENDS IN BIOCHEMICAL SCIENCES

von Willebrand factor, Jedi knight of the bloodstream

(2014) T. A. Springer   BLOOD

Concentration-Dependent Reversible Self-Oligomerization of Serum Albumins through Intermolecular β-Sheet Formation

(2014) Arpan Bhattacharya et al.   LANGMUIR

Making Sense of Brownian Motion: Colloid Characterization by Dynamic Light Scattering

(2014) Puthusserickal A. Hassan et al.   LANGMUIR

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

(2013) P. Patrizia Mangione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimized Cross-Slot Flow Geometry for Microfluidic Extensional Rheometry

(2012) Simon J. Haward et al.   PHYSICAL REVIEW LETTERS

Improved drug-like properties of therapeutic proteins by directed evolution

(2012) A. Buchanan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Physical degradation of proteins in well-defined fluid flows studied within a four-roll apparatus

(2011) S. Simon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Insights into the Mechanism of Aggregation and Fibril Formation from Bovine Serum Albumin

(2011) Mily Bhattacharya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Bovine serum albumin unfolds in Couette flow

(2011) Innocent B. Bekard et al.   Soft Matter

Free-Solution, Label-Free Protein-Protein Interactions Characterized by Dynamic Light Scattering

(2010) Amy D. Hanlon et al.   BIOPHYSICAL JOURNAL

Elongational Flow Induces the Unfolding of von Willebrand Factor at Physiological Flow Rates

(2010) Charles E. Sing et al.   BIOPHYSICAL JOURNAL

Effects of shear on proteins in solution

(2010) C. R. Thomas et al.   BIOTECHNOLOGY LETTERS

Unravelling the design principles for single protein mechanical strength

(2010) Neal Crampton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein aggregation—Pathways and influencing factors

(2010) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

pH-induced Conformational Isomerization of Bovine Serum Albumin Studied by Extrinsic and Intrinsic Protein Fluorescence

(2010) Mily Bhattacharya et al.   JOURNAL OF FLUORESCENCE

Hydrodynamic effects in proteins

(2010) Piotr Szymczak et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

(2010) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Shear-Induced Unfolding of Lysozyme Monitored In Situ

(2009) Lorna Ashton et al.   BIOPHYSICAL JOURNAL

Response of a concentrated monoclonal antibody formulation to high shear

(2009) Jared S. Bee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Current Perspectives on Stability of Protein Drug Products during Formulation, Fill and Finish Operations

(2008) N. Rathore et al.   BIOTECHNOLOGY PROGRESS

Assembly mechanism of recombinant spider silk proteins

(2008) S. Rammensee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA