Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors

Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice

(2019) Abdus Sattar Bhuiyan et al.   HYPERTENSION RESEARCH

Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study

(2019) Sadayoshi Ito et al.   JOURNAL OF HUMAN HYPERTENSION

Efficacy and Safety of Esaxerenone (CS-3150) for the Treatment of Type 2 Diabetes with Microalbuminuria

(2019) Sadayoshi Ito et al.   Clinical Journal of the American Society of Nephrology

Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

(2019) Hiroshi Itoh et al.   HYPERTENSION RESEARCH

The (pro)renin receptor in health and disease

(2019) Atsuhiro Ichihara et al.   Nature Reviews Nephrology

(Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma—Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis

(2019) Maider Beitia et al.   Cancers

Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes

(2018) Itamar Couto Guedes de Jesus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pathophysiology of Glucocorticoid Signaling

(2018) Géraldine Vitellius et al.   ANNALES D ENDOCRINOLOGIE

Novel mechanisms of G-protein-coupled receptors functions: AT 1 angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk

(2018) András D. Tóth et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Independent regulation of renin–angiotensin–aldosterone system in the kidney

(2018) Akira Nishiyama et al.   Clinical and Experimental Nephrology

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue

(2018) Kohji Ohki et al.   Scientific Reports

(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations

(2018) Juan Wang et al.   BRITISH JOURNAL OF CANCER

Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease

(2018) Akira Nishiyama   HYPERTENSION RESEARCH

Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats

(2018) Lei Li et al.   HYPERTENSION RESEARCH

A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and diabetic nephropathy

(2017) Shigehiro Katayama et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

(Pro)renin receptor is crucial for glioma development via the Wnt/β-catenin signaling pathway

(2017) Masaaki Kouchi et al.   JOURNAL OF NEUROSURGERY

The (pro)renin receptor and its interaction partners

(2017) Jörg Peters   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin

(2017) Kazushi Uneda et al.   Journal of the American Heart Association

Adipocyte‐Specific Enhancement of Angiotensin II Type 1 Receptor‐Associated Protein Ameliorates Diet‐Induced Visceral Obesity and Insulin Resistance

(2017) Kengo Azushima et al.   Journal of the American Heart Association

A Randomized Controlled Study of Finerenone vs. Eplerenone in Japanese Patients With Worsening Chronic Heart Failure and Diabetes and/or Chronic Kidney Disease

(2016) Naoki Sato et al.   CIRCULATION JOURNAL

A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease

(2016) Gerasimos Filippatos et al.   EUROPEAN HEART JOURNAL

G-Protein–Coupled Receptor MrgD Is a Receptor for Angiotensin-(1–7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase ANovelty and Significance

(2016) Anja Tetzner et al.   HYPERTENSION

Mineralocorticoid receptor as a therapeutic target in chronic kidney disease and hypertension

(2016) Shigeru Shibata et al.   HYPERTENSION RESEARCH

Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists Cause Differential Cardiac Gene Expression in Pressure Overload-induced Cardiac Hypertrophy

(2016) Jana Grune et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis

(2016) Arivajiagane Arundhathi et al.   Oncotarget

Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy

(2016) Shin Ito et al.   Journal of the American Heart Association

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

(2015) Shu Zhu et al.   CELLULAR SIGNALLING

Angiotensin II Type 1 Receptor Binding Molecule ATRAP as a Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology

(2015) K. Tamura et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist

(2015) Kiyoshi Arai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats

(2015) Kiyoshi Arai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload–Induced Cardiac InjuryNovelty and Significance

(2015) Nobuhiro Ayuzawa et al.   HYPERTENSION

Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging

(2015) Takehiro Kamo et al.   International Heart Journal

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

(2015) George L. Bakris et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ATP6AP2/(Pro)renin Receptor Contributes to Glucose Metabolism via Stabilizing the Pyruvate Dehydrogenase E1 β Subunit

(2015) Atsuhiro Kanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin-(1-7) Protects against the Development of Aneurysmal Subarachnoid Hemorrhage in Mice

(2015) Kenji Shimada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma

(2015) Yuki Shibayama et al.   Scientific Reports

Expression of (pro)renin receptor in breast cancers and its effect on cancercell proliferation

(2014) Koji OHBA et al.   BIOMEDICAL RESEARCH-TOKYO

Angiotensin II and Vascular Injury

(2014) Augusto C. Montezano et al.   CURRENT HYPERTENSION REPORTS

Alamandine

(2014) Daniel C. Villela et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Effects of Cardiac Overexpression of the Angiotensin II Type 2 Receptor on Remodeling and Dysfunction in Mice Post–Myocardial Infarction

(2014) Jiang Xu et al.   HYPERTENSION

Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury

(2014) Peter Kolkhof et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Deletion of the angiotensin II type 1 receptor–associated protein enhances renal sodium reabsorption and exacerbates angiotensin II–mediated hypertension

(2014) Masato Ohsawa et al.   KIDNEY INTERNATIONAL

Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension

(2013) Hiromichi Wakui et al.   CARDIOVASCULAR RESEARCH

Discovery and Characterization of Alamandine

(2013) Roberto Queiroga Lautner et al.   CIRCULATION RESEARCH

The Physiology and Pathophysiology of a Novel Angiotensin Receptor-binding Protein ATRAP/Agtrap

(2013) Kouichi Tamura et al.   CURRENT PHARMACEUTICAL DESIGN

Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking

(2013) Tobias Hermle et al.   EMBO JOURNAL

Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial

(2013) Bertram Pitt et al.   EUROPEAN HEART JOURNAL

Enhanced Angiotensin Receptor-Associated Protein in Renal Tubule Suppresses Angiotensin-Dependent Hypertension

(2013) Hiromichi Wakui et al.   HYPERTENSION

Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1–7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor Blockade

(2013) Kousei Ohshima et al.   HYPERTENSION

Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors

(2013) Michael E. Baker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Increased expression of (pro)renin receptor in aldosterone-producing adenomas

(2013) Hajime Yamamoto et al.   PEPTIDES

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

(2013) Xiaoping Zhang et al.   PLoS One

Effect of Angiotensin II Type 2 Receptor-Interacting Protein on Adipose Tissue Function via Modulation of Macrophage Polarization

(2013) Fei Jing et al.   PLoS One

Angiotensin Receptor–Binding Protein ATRAP/ Agtrap Inhibits Metabolic Dysfunction With Visceral Obesity

(2013) Akinobu Maeda et al.   Journal of the American Heart Association

Mineralocorticoid Receptor-Associated Hypertension and Its Organ Damage: Clinical Relevance for Resistant Hypertension

(2012) H. Shibata et al.   AMERICAN JOURNAL OF HYPERTENSION

Regulation of angiotensin II receptors beyond the classical pathway

(2012) Masatsugu Horiuchi et al.   CLINICAL SCIENCE

Angiotensin-(1–7): beyond the cardio-renal actions

(2012) Danielle G. Passos-Silva et al.   CLINICAL SCIENCE

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Angiotensin II type 2 receptor-interacting protein prevents vascular senescence

(2012) Li-Juan Min et al.   Journal of the American Society of Hypertension

AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function

(2012) Shetal H. Padia et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space

(2011) Ayumu Yoshikawa et al.   HYPERTENSION RESEARCH

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

(2011) Shigeru Shibata et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor

(2010) Tina Buechling et al.   CURRENT BIOLOGY

Cardiac-Specific Activation of Angiotensin II Type 1 Receptor–Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II–Infused Mice

(2010) Hiromichi Wakui et al.   HYPERTENSION

Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats

(2010) Kazi Rafiq et al.   JOURNAL OF HYPERTENSION

Pathophysiological Roles of Aldosterone and Mineralocorticoid Receptor in the Kidney

(2010) Kazi Rafiq et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma

(2009) Christelle Cousin et al.   HYPERTENSION

Attenuation of Cuff-Induced Neointimal Formation by Overexpression of Angiotensin II Type 2 Receptor-Interacting Protein 1

(2009) Teppei Fujita et al.   HYPERTENSION

Effects of Angiotensin Metabolites in the Coronary Vascular Bed of the Spontaneously Hypertensive Rat

(2009) Els Moltzer et al.   HYPERTENSION

Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis

(2008) Kyo-Hwa Kang et al.   CARDIOVASCULAR RESEARCH

The Trafficking Protein GABARAP Binds to and Enhances Plasma Membrane Expression and Function of the Angiotensin II Type 1 Receptor

(2008) Julia L. Cook et al.   CIRCULATION RESEARCH

Molecular Mechanisms Involved in the Angiotensin-(1-7)/Mas Signaling Pathway in Cardiomyocytes

(2008) Marco F. Dias-Peixoto et al.   HYPERTENSION

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE