Article
Peripheral Vascular Disease
Alexandros Rovas, Irina Osiaevi, Konrad Buscher, Jan Sackarnd, Phil-Robin Tepasse, Manfred Fobker, Joachim Kuehn, Stephan Braune, Ulrich Goebel, Gerold Thoelking, Andreas Groeschel, Hermann Pavenstaedt, Hans Vink, Philipp Kuempers
Summary: Our study found that COVID-19 patients have reduced microvascular density, slower red blood cell velocity, and glycocalyx damage. Elevated markers of endothelial dysfunction are associated with disease severity and can predict 60-day in-hospital mortality.
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Summary: This study demonstrates that in septic patients, serum syndecan-1 levels are associated with 28-day mortality, coagulation failure, and renal failure. Elevated syndecan-1 levels may lead to persistent thrombocytopenia and a lethal outcome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ronodeep Mitra, Alina Nersesyan, Kaleigh Pentland, M. Mark Melin, Robert M. Levy, Eno E. Ebong
Summary: The endothelial glycocalyx (GCX), a protective covering for endothelial cells, plays an important role in maintaining endothelial function. This study investigated the effect of diosmin on GCX integrity and endothelial function in a mouse model. The results showed that diosmin treatment improved GCX coverage, reduced inflammation, and restored vascular tone. These findings suggest that diosmin may be a potential therapy for endothelial dysfunction.
Article
Critical Care Medicine
John W. Keyloun, Tuan D. Le, Anthony E. Pusateri, Robert L. Ball, Bonnie C. Carney, Thomas Orfeo, Kathleen E. Brummel-Ziedins, Maria C. Bravo, Melissa M. McLawhorn, Lauren T. Moffatt, Jeffrey W. Shupp
Summary: This study aimed to evaluate the association between admission plasma levels of Syndecan-1 and Tissue Factor Pathway Inhibitor in burn patients and their ability to predict 30-day mortality. The results showed that higher levels of SDC-1 and TFPI upon admission were significantly associated with an increased risk of 30-day mortality, with SDC-1 performing better as a predictor of mortality.
Review
Medicine, General & Internal
Nchafatso G. Obonyo, Declan P. Sela, Sainath Raman, Reema Rachakonda, Bailey Schneider, Louise E. See Hoe, Jonathon P. Fanning, Gianluigi Li Bassi, Kathryn Maitland, Jacky Y. Suen, John F. Fraser
Summary: This study aimed to review the literature on resuscitation-associated and resuscitation-induced endotheliopathy. The results showed that the biomarker syndecan-1 had the highest frequency of assessment in the post-resuscitation period, and changes in concentrations showed a statistically significant effect of the resuscitation. However, there is inadequate data available in this area, and further research and standardization of the ideal assessment and panel of biomarkers are urgently needed.
SYSTEMATIC REVIEWS
(2023)
Article
Medicine, General & Internal
Hironori Matsumoto, Suguru Annen, Naoki Mukai, Muneaki Ohshita, Satoru Murata, Yutaka Harima, Shirou Ogawa, Mitsuo Okita, Yuki Nakabayashi, Satoshi Kikuchi, Jun Takeba, Norio Sato
Summary: This study aimed to evaluate the association between endotheliopathy represented by high levels of circulating syndecan-1 (SDC-1) and coagulofibrinolytic responses due to trauma. The results showed that elevated SDC-1 levels were associated with intense and prolonged coagulation activation, impairment of anticoagulation, fibrinolytic activation, and consumption coagulopathy, which are all related to the development of DIC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Quan Zhang, Zhan Ye, Antonia Bignotti, X. Long Zheng
Summary: Endotheliopathy and elevated plasma syndecan-1 are common in patients with COVID-19, and higher levels of syndecan-1 are associated with disease severity and increased mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
Summary: This study found that early administration of ascorbic acid (AsA) can protect vascular endothelial cells by inhibiting the oxidation of BH4 in septic mice, reducing organ dysfunction and improving survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Sharven Taghavi, Sarah Abdullah, Farhana Shaheen, Jacob Packer, Juan Duchesne, Stephen E. Braun, Chad Steele, Derek Pociask, Jay K. Kolls, Olan Jackson-Weaver
Summary: Exosomes and microvesicles derived from adipose-derived mesenchymal stem cells (ASCs) can protect the endothelial glycocalyx from LPS injury, potentially through the action of a specific enzyme.
Article
Medicine, General & Internal
Balazs Sagi, Szilard Kun, Rita Klaudia Jakabfi-Csepregi, Endre Sulyok, Botond Csiky
Summary: This study found that acute vascular changes occur in chronic hemodialysis patients during the dialysis process, mediated by factors related to the endothelium. These changes are correlated with cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandros Rovas, Julia Katharina Neumann, Carolin Christina Drost, Richard Vollenberg, Gerold Thoelking, Manfred Fobker, Martin Witzenrath, Philipp Kuempers, AGAMOTTO Study Group, CAPNETZ Study Group
Summary: Measuring urinary concentration of sulphated glycosaminoglycans (sGAGs) can serve as a method to assess disease severity and outcome in patients with COVID-19 and community-acquired pneumonia (CAP).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Review
Biochemistry & Molecular Biology
Jerremy Weerts, Sanne G. J. Mourmans, Arantxa Barandiaran Aizpurua, Blanche L. M. Schroen, Christian Knackstedt, Etto Eringa, Alfons J. H. M. Houben, Vanessa P. M. van Empel
Summary: Heart failure with preserved ejection fraction (HFpEF) is a disease with increasing incidence and no effective treatment. Coronary microvascular dysfunction plays a key role in the pathophysiology of HFpEF, possibly due to a low-grade pro-inflammatory state caused by systemic comorbidities. The presence or absence of peripheral microvascular dysfunction in HFpEF may reflect whether it is predominantly a cardiac or a systemic disease.
Article
Surgery
August Adelsten Olsen, Rune Broni Strandby, Nikolaj Nerup, Par Ingemar Johansson, Lars Bo Svendsen, Michael Patrick Achiam
Summary: The study aimed to determine the relationship between mesenteric traction syndrome (MTS) and systemic inflammation, as well as glycocalyx and endothelial cell dysfunction, and their correlation with postoperative morbidity. Severe MTS was associated with increased postoperative morbidity, potentially due to preoperative elevated plasma epinephrine and a more pronounced proinflammatory response and endothelial damage. Further research is needed to confirm these findings in a new prospective cohort.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Nobuaki Hamazaki, Kentaro Kamiya, Shohei Yamamoto, Kohei Nozaki, Takafumi Ichikawa, Ryota Matsuzawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Kentaro Meguro, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: The impact of baseline kidney function on outcomes following comprehensive cardiac rehabilitation in heart failure patients was investigated. Participation in outpatient CR was associated with lower clinical events in subgroups of different eGFR stages, indicating a better prognosis and positive change in physical function in heart failure patients with low kidney function.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ayaka Sato, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: The study examined the relationship between gait speed/6MWD and difficulties in activities of daily living in patients with cardiovascular disease. Results showed significant correlations between gait speed, 6MWD, and difficulty in ADL, providing a potential tool for assessing functional decline risk in patients.
Letter
Cardiac & Cardiovascular Systems
Shinya Tanaka, Kentaro Kamiya, Yuya Matsue, Ryusuke Yonezawa, Hiroshi Saito, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Masashi Yamashita, Kazuki Wakaume, Yoshiko Endo, Emi Maekawa, Minako Yamaoka-Tojo, Takaaki Shiono, Takayuki Inomata, Junya Ako
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Geriatrics & Gerontology
Masashi Yamashita, Kentaro Kamiya, Atsuhiko Matsunaga, Tadashi Kitamura, Nobuaki Hamazaki, Takafumi Ichikawa, Shota Uchida, Takumi Noda, Naoya Yanagi, Emi Maekawa, Minako Yamaoka-Tojo, Junya Ako, Kagami Miyaji
Summary: This study found that muscle density consistently declined after acute care, especially the erector spine muscles, which also significantly decreased in size. A higher decline in muscle density was associated with a slower recovery of physical function during in-hospital cardiac rehabilitation in patients with aortic diseases.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Hidenori Kariya, Minako Yamaoka-Tojo, Nobuaki Hamazaki, Shinichi Obara, Lisa Kitasato, Atsuhiko Matsunaga, Junya Ako
Summary: Higher instrumental activities of daily living (IADL) frequency is independently associated with better outcomes in older patients with cardiovascular disease (CVD), indicating the importance of preserving instrumental activities as part of cardiovascular rehabilitation.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Geriatrics & Gerontology
Yohei Yamato, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Takumi Noda, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: This study compares frailty diagnostic criteria in older patients with cardiovascular disease and finds that the FSI and FRAIL scale show moderate agreement with the Fried criteria and have comparable prognostic value. However, only the FRAIL scale is as accurate as the Fried criteria in screening for physical dysfunction.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ayuko Kashima, Kentaro Kamiya, Nobuaki Hamazaki, Kensuke Ueno, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Takumi Noda, Kazuki Hotta, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: This study investigated the effect of SGLT2 inhibitors on patients with cardiovascular disease and type 2 diabetes undergoing comprehensive outpatient cardiac rehabilitation. The results showed that the use of SGLT2 inhibitors did not impair the improvement in physical functions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shigeru Makita, Takanori Yasu, Yoshihiro J. Akashi, Hitoshi Adachi, Hideo Izawa, Shunichi Ishihara, Yoshitaka Iso, Hideo Ohuchi, Kazuto Omiya, Yusuke Ohya, Koichi Okita, Yutaka Kimura, Akira Koike, Masahiro Kohzuki, Shinji Koba, Masataka Sata, Kazunori Shimada, Tomoki Shimokawa, Hirokazu Shiraishi, Naokata Sumitomo, Tetsuya Takahashi, Tomoyuki Takura, Hiroyuki Tsutsui, Masatoshi Nagayama, Emiko Hasegawa, Yoshihiro Fukumoto, Yutaka Furukawa, Shin-ichiro Miura, Satoshi Yasuda, Sumio Yamada, Yuichiro Yamada, Dai Yumino, Toshiko Yoshida, Takuji Adachi, Toshimi Ikegame, Kazuhiro P. Izawa, Takeshi Ishida, Neiko Ozasa, Naohiko Osada, Hiroaki Obata, Naoya Kakutani, Yusuke Kasahara, Masaaki Kato, Kentaro Kamiya, Shintaro Kinugawa, Yuji Kono, Yasuyuki Kobayashi, Teruyuki Koyama, Kazuhiro Sase, Shinji Sato, Tatsuhiro Shibata, Norio Suzuki, Daisuke Tamaki, Minako Yamaoka-Tojo, Michio Nakanishi, Eisaku Nakane, Mari Nishizaki, Taiki Higo, Kanta Fujimi, Tasuku Honda, Yasuharu Matsumoto, Noriko Matsumoto, Ikuko Miyawaki, Makoto Murata, Shusuke Yagi, Masanobu Yanase, Midori Yamada, Miho Yokoyama, Noboru Watanabe, Haruki Ito, Takeshi Kimura, Syunei Kyo, Yoichi Goto, Ryuji Nohara, Ken-Ichi Hirata
CIRCULATION JOURNAL
(2023)
Article
Geriatrics & Gerontology
Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Kensuke Ueno, Emi Maekawa, Tasuku Terada, Jennifer L. Reed, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: In older patients with cardiovascular disease and cognitive impairment, the SARC-F questionnaire may be a simple and inexpensive tool for identifying patients with decreased motor function and a poor prognosis.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Saki Shakuta, Masashi Yamashita, Kentaro Kamiya, Nobuaki Hamazaki, Kensuke Ueno, Kohei Nozaki, Shota Uchida, Takumi Noda, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: In patients with heart failure, the spread of COVID-19 is found to be associated with the development of social frailty and depressive symptoms. Evaluating these symptoms at hospital discharge can help in managing the disease and understanding the patients' social and psychological conditions.
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Masashi Yamashita, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Junya Ako
Summary: This study found that serum cholinesterase (ChE) is more effective than existing blood chemical tests and nutritional scores in predicting prognosis and discriminating undernutrition status in patients with heart failure (HF).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Kohei Nozaki, Nobuaki Hamazaki, Kentaro Kamiya, Hidenori Kariya, Shota Uchida, Takumi Noda, Kensuke Ueno, Emi Maekawa, Atsuhiko Matsunaga, Minako Yamaoka-Tojo, Junya Ako
Summary: This study investigated the differences in IADL frequency between the sexes at the end of cardiac rehabilitation and its impact on outcomes in patients with heart failure. The results showed that higher IADL frequency was independently associated with reduced all-cause mortality and combined events. Additionally, there was no difference in the relationship between sex and all-cause mortality.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Shinya Tanaka, Kentaro Kamiya, Yuya Matsue, Ryusuke Yonezawa, Hiroshi Saito, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Masashi Yamashita, Kazuki Wakaume, Yoshiko Endo, Emi Maekawa, Minako Yamaoka-Tojo, Takaaki Shiono, Takayuki Inomata, Junya Ako
Summary: Frailty in older patients with acute heart failure (AHF) negatively impacts clinical outcomes. Adding electrical muscle stimulation (EMS) to early rehabilitation may improve treatment effects. In this study, the EMS group showed significant improvements in quadriceps' isometric strength and SPPB compared to the control group, with no significant differences in other indexes of physical function and cognitive function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Kensuke Ueno, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Masashi Kawabata, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: This study aimed to investigate the usefulness of SF-36PF as a predictor of exercise intolerance in patients with HF and provide its optimal cut-off value. The results showed that SF-36PF is significantly associated with exercise intolerance and can be used as an alternative index for patients with HF.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)