Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nan-Nan Sha, Jia-Li Zhang, Christina Chui-Wa Poon, Wen-Xiong Li, Yue Li, Yi-Fei Wang, Wei Shi, Fu-Hui Lin, Wen-Ping Lin, Yong-Jun Wang, Yan Zhang
Summary: In this study, it was found that ANG II and ANG(1-7) had different effects on osteoblasts and osteoclasts under high-glucose conditions, playing different roles in the development of osteoporosis, with ANG(1-7) showing a protective effect against diabetes-induced osteoporosis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Critical Care Medicine
Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphael Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni
Summary: The aim of this study was to investigate the effects of Ang-(1-7) infusion on the development and severity of septic shock. The results showed that early Ang-(1-7) infusion can prevent the development of septic shock, reduce norepinephrine requirements, limit the increase of interleukin-6 levels, and prevent renal dysfunction.
Article
Biochemistry & Molecular Biology
Dominga Lapi, Maurizio Cammalleri, Massimo Dal Monte, Martina Di Maro, Mariarosaria Santillo, Anna Belfiore, Gilda Nasti, Simona Damiano, Rossella Trio, Martina Chiurazzi, Barbara De Conno, Nicola Serao, Paolo Mondola, Antonio Colantuoni, Bruna Guida
Summary: The study found that Ang II and Ang 1-7 trigger different mechanisms through different receptors to affect cerebral microvascular injury in rats. Ang II exacerbates damage, while Ang 1-7 protects the microcirculation and can be regulated by specific receptor antagonists and activators.
Article
Orthopedics
Ying Li, Jiao Song, Yangyang Jiang, Xue Yang, Li Cao, Chun Xiao, Suli Li, Birong Dong, Xiaoli Huang
Summary: The ACE2/Ang-(1-7) axis plays a protective role in skeletal muscle function and administering exogenous Ang-(1-7) can delay age-related decline in skeletal muscle function. Aged mice showed reduced skeletal muscle function and Ang-(1-7) expression levels compared to younger mice. ACE2KO mice had significantly lower skeletal muscle function and MEF2A protein expression than age-matched wild-type mice. After one month of Ang-(1-7) treatment, skeletal muscle function in aged ACE2KO mice improved, with similar MEF2A protein expression to the untreated group. Ang-(1-7) was shown to promote Glut4 expression in C2C12 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Peripheral Vascular Disease
Brasilina Caroccia, Paul-Emmanuel Vanderriele, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Selene Prisco, Francesca Torresan, Oliver Domenig, Maurizio Iacobone, Marko Poglitsch, Gian Paolo Rossi
Summary: This study found that ACE-2 mRNA and Ang II were present in human adrenocortical tissues, but not Ang-(1-7) and Ang-(1-5). Ang-(1-7) and ACE-2 do not seem to play a significant role in regulating aldosterone and cortisol biosynthesis.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu, Yan-Fen Chai
Summary: There is an abnormal activation of the renin angiotensin aldosterone system (RAAS) in patients with Sepsis-Induced Cardiomyopathy (SIC). This study measured the protein concentrations of angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) in peripheral plasma collected from SIC patients and healthy controls, and explored the relationship between SIC, Ang II, and Ang-(1-7) levels. It was found that SIC patients had elevated Ang II and Ang II/Ang-(1-7) levels, while the healthy controls had higher Ang-(1-7) levels. Additionally, exogenous Ang-(1-7) showed protective effects against SIC by inhibiting inflammatory and oxidative stress pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ying Zhu, Daliang Xu, Fang Deng, Yonglin Yan, Jian Li, Chenyu Zhang, Jing Chu
Summary: The study found that Ang-(1-7) can reduce Ang II levels in kidneys, inhibit NF-kappa B signaling, decrease inflammatory response and oxidative stress, thereby helping to alleviate sepsis-induced acute kidney injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Minela Aida Maranduca, Daniela Maria Tanase, Cristian Tudor Cozma, Nicoleta Dima, Andreea Clim, Alin Constantin Pinzariu, Dragomir Nicolae Serban, Ionela Lacramioara Serban
Summary: The COVID-19 pandemic has placed significant stress on the medical community. ACE2, a cellular receptor for the virus, has been identified as a crucial component in the renin-angiotensin-aldosterone system (RAAS) and is responsible for various processes in different organs. Infection with SARS-CoV-2 leads to downregulation of ACE2 and disrupts the balance between ACE and ACE2 in organs, resulting in observed effects of COVID-19 infection.
Article
Chemistry, Medicinal
Sana Khajeh Pour, Arina Ranjit, Emma L. Summerill, Ali Aghazadeh-Habashi
Summary: This study evaluated the anti-inflammatory effects of a novel and stable conjugate of Ang-(1-7) in a rat model of arthritis. The results showed that the conjugate reduced inflammation-related body weight loss and joint edema, and decreased nitric oxide levels. In addition, the conjugate modulated the components of the renin-angiotensin system and exhibited enhanced therapeutic effects.
Article
Cell Biology
Carlos M. Ferrario, Leanne Groban, Hao Wang, Che Ping Cheng, Jessica L. VonCannon, Kendra N. Wright, Xuming Sun, Sarfaraz Ahmad
Summary: The discovery of the dodecapeptide angiotensin-(1-12) as an alternate form of angiotensin I has shed light on noncanonical mechanisms for renin independent generation of angiotensins. Studies have confirmed the presence of Ang-(1-12) in multiple organs in both humans and rats, serving as a substrate for Ang II formation. Research has shown that angiotensin II can be generated from angiotensin-(1-12) without the involvement of renin, with chymase playing a key role in this conversion process.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Katie L. Collins, Usir S. Younis, Sasipa Tanyaratsrisakul, Robin Polt, Meredith Hay, Heidi M. Mansour, Julie G. Ledford
Summary: The peptide hormone Ang-(1-7) has been shown to have anti-inflammatory effects and reduce airway inflammation. It also plays a protective role in reducing lung infection burden and inflammation caused by Mycoplasma pneumonia, suggesting its potential therapeutic value in respiratory infections.
Article
Biochemistry & Molecular Biology
Anshul S. S. Jadli, Noura N. N. Ballasy, Karina P. P. Gomes, Cameron D. A. Mackay, Megan Meechem, Tishani Methsala Wijesuriya, Darrell Belke, Jennifer Thompson, Paul W. M. Fedak, Vaibhav B. B. Patel
Summary: Thoracic aortic aneurysm (TAA) involves remodeling of the aortic wall and can lead to dissection and rupture. This study investigated the effects of angiotensin (Ang) 1-7 on TAA in a mouse model. The results showed that Ang 1-7 prevented vascular remodeling and the development of TAA, suggesting it may be a potential therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Victor Teatini Ribeiro, Thiago Macedo e Cordeiro, Roberta da Silva Filha, Lucas Giandoni Perez, Paulo Caramelli, Antonio Lucio Teixeira, Leonardo Cruz de Souza, Ana Cristina Simoes e Silva
Summary: The study revealed significantly lower plasma levels of Ang-(1-7) in AD patients compared to controls, with no significant difference in Ang II. A positive correlation was found between Ang-(1-7) levels and white matter hypointensities volumes in AD patients, indicating a potential interaction between Ang-(1-7) and cerebrovascular lesions in AD.
FRONTIERS IN NEUROSCIENCE
(2021)
