Purinergic Regulation of Endothelial Barrier Function

Update of P2Y Receptor Pharmacology: IUPHAR Review:27

(2020) Kenneth A. Jacobson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ticagrelor Enhances Release of Anti-Hypoxic Cardiac Progenitor Cell-Derived Exosomes Through Increasing Cell Proliferation In Vitro

(2020) Valentina Casieri et al.   Scientific Reports

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis

(2020) Ruo‐Xue Wen et al.   CNS Neuroscience & Therapeutics

Hydroxysafflor Yellow A Together with Blood–Brain Barrier Regulator Lexiscan for Cerebral Ischemia Reperfusion Injury Treatment

(2020) Liwei Tan et al.   ACS Omega

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

(2020) Hossam Kadry et al.   Fluids and Barriers of the CNS

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

(2019) Maria Paz Prada et al.   eLife

Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation

(2019) Nina Wettschureck et al.   PHYSIOLOGICAL REVIEWS

Blood-retinal barrier protection against high glucose damage: The role of P2X7 receptor

(2019) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

Damage-associated molecular patterns in trauma

(2019) Borna Relja et al.   European Journal of Trauma and Emergency Surgery

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

(2019) Dursun Gündüz et al.   Frontiers in Physiology

A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine

(2019) Elisabetta De Filippo et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson

(2018) Rebecca W. Pak et al.   Biomedical Optics Express

P2 receptor interaction and signalling cascades in neuroprotection

(2018) Mª Teresa Miras-Portugal et al.   BRAIN RESEARCH BULLETIN

Blood–Brain Barrier in a Haemophilus influenzae Type a In Vitro Infection: Role of Adenosine Receptors A2A and A2B

(2017) N. Caporarello et al.   MOLECULAR NEUROBIOLOGY

Effect of ticagrelor on endothelial calcium signalling and barrier function

(2017) Dursun Gündüz et al.   THROMBOSIS AND HAEMOSTASIS

Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression

(2016) Lakshmi Galam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial Cell–Specific Deletion of P2Y 2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null MiceHighlights

(2016) Xingjuan Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Mouse P2Y6Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy

(2016) Sophie Clouet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells

(2016) Fanghe Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Direct Evidence for P2Y2 Receptor Involvement in Vascular Response to Injury

(2016) Yuksel Agca et al.   JOURNAL OF VASCULAR RESEARCH

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

(2016) Liang Han et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion

(2016) Melanie Kaiser et al.   Purinergic Signalling

A critical look at the function of the P2Y11 receptor

(2016) Karin Dreisig et al.   Purinergic Signalling

ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain BarrierIn Vitro

(2016) Fuxing Yang et al.   NEURAL PLASTICITY

The P2X4 receptor is required for neuroprotection via ischemic preconditioning

(2016) Tomohiko Ozaki et al.   Scientific Reports

Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells

(2016) Anar Dushpanova et al.   Scientific Reports

Purinergic transmission in blood vessels

(2015) Vera Ralevic et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Activation of Adenosine Receptor Potentiates the Anticonvulsant Effect of Phenytoin Against Amygdala Kindled Seizures

(2015) Zhen Sun et al.   CNS & Neurological Disorders-Drug Targets

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Mouse P2Y4Nucleotide Receptor Protects against Myocardial Infarction through Endothelin-1 Downregulation

(2015) Michael Horckmans et al.   JOURNAL OF IMMUNOLOGY

The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain

(2015) Sadhana Jackson et al.   JOURNAL OF NEURO-ONCOLOGY

Shear stress modulates endothelial KLF2 through activation of P2X4

(2015) R. Sathanoori et al.   Purinergic Signalling

P2X4 receptor–eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure

(2015) Ronghua Yang et al.   Computational and Structural Biotechnology Journal

Overcoming the Blood–Brain Barrier for Delivering Drugs into the Brain by Using Adenosine Receptor Nanoagonist

(2014) Xihui Gao et al.   ACS Nano

P2Y 6 Deficiency Limits Vascular Inflammation and Atherosclerosis in Mice

(2014) Peter Stachon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular nucleotide and nucleoside signaling in vascular and blood disease

(2014) M. Idzko et al.   BLOOD

Adenosine

(2014) Jamie Layland et al.   JACC-Cardiovascular Interventions

A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability

(2014) Do-Geun Kim et al.   MOLECULAR NEUROBIOLOGY

P2Y6 Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

(2014) Ricardo A. Garcia et al.   PLoS One

Adenosine A3 Receptor Activation Attenuates Lung Ischemia-Reperfusion Injury

(2013) Daniel P. Mulloy et al.   ANNALS OF THORACIC SURGERY

Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries

(2013) M Alsaqati et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent

(2013) Franziska M. Konrad et al.   FASEB JOURNAL

Endothelial Junction Regulation: A Prerequisite for Leukocytes Crossing the Vessel Wall

(2013) Anna E. Daniel et al.   Journal of Innate Immunity

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Nucleoside triphosphates inhibit ADP, collagen, and epinephrine-induced platelet aggregation: Role of P2Y1 and P2Y12 receptors

(2013) Muhammad Aslam et al.   THROMBOSIS RESEARCH

Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats

(2013) Robert I. Menzies et al.   Frontiers in Physiology

Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

(2012) Franziska M. Konrad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

P2Y4 nucleotide receptor: a novel actor in post-natal cardiac development

(2012) Michael Horckmans et al.   ANGIOGENESIS

Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature

(2012) Dursun Gündüz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Purinergic 2Y1 Receptor Stimulation Decreases Cerebral Edema and Reactive Gliosis in a Traumatic Brain Injury Model

(2012) Lora Talley Watts et al.   JOURNAL OF NEUROTRAUMA

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Thrombin-induced ATP release from human umbilical vein endothelial cells

(2011) Stefanie Gödecke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1

(2011) Muhammad Aslam et al.   CARDIOVASCULAR RESEARCH

Major Contribution of the P2Y 1 Receptor in Purinergic Regulation of TNFα-Induced Vascular Inflammation

(2011) Murielle Zerr et al.   CIRCULATION

P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: an immunohistochemical and ultrastructural study

(2011) Kiyoko Uehara et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure

(2011) Leanne Stokes et al.   HYPERTENSION

Adenosine A1 receptor activation is arrhythmogenic in the developing heart through NADPH oxidase/ERK- and PLC/PKC-dependent mechanisms

(2011) Elodie Robin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier

(2011) A. J. Carman et al.   JOURNAL OF NEUROSCIENCE

Human brain endothelial cells are responsive to adenosine receptor activation

(2011) Jeffrey H. Mills et al.   Purinergic Signalling

P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells

(2010) Taras Lyubchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Myocardial adenosine A1-receptor-mediated adenoprotection involves phospholipase C, PKC-ε, and p38 MAPK, but not HSP27

(2010) Richard A. Fenton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement

(2010) Qing Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17

(2010) Muhammad Aslam et al.   CARDIOVASCULAR RESEARCH

Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability

(2009) Uwe Pfeil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adenosine: An Old Drug Newly Discovered

(2009) Holger K. Eltzschig   ANESTHESIOLOGY

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

(2009) Puneet Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B Adenosine Receptor

(2009) Y. Zhou et al.   JOURNAL OF IMMUNOLOGY

Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro

(2009) Filip Kukulski et al.   MOLECULAR IMMUNOLOGY

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Reduced Atherosclerotic Lesions in P2Y 1 /Apolipoprotein E Double-Knockout Mice

(2008) Béatrice Hechler et al.   CIRCULATION

The role of adherens junctions and VE-cadherin in the control of vascular permeability

(2008) E. Dejana et al.   JOURNAL OF CELL SCIENCE

A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice

(2008) Tobias Eckle et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockout Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells

(2008) I. Bar et al.   MOLECULAR PHARMACOLOGY

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

(2008) B. C. Capell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis

(2008) J. H. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA