A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders

(2018) Madeline Nieves-Cintrón et al.   MICROCIRCULATION

Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes

(2018) Gopireddy Raghavender Reddy et al.   JOURNAL OF GENERAL PHYSIOLOGY

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

(2017) Paul K. Whelton et al.   HYPERTENSION

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

(2017) Sendoa Tajada et al.   JOURNAL OF GENERAL PHYSIOLOGY

cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes

(2017) Timothy B. Johnstone et al.   MOLECULAR PHARMACOLOGY

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

(2017) Akiyuki Nishimura et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes

(2017) Madeline Nieves-Cintrón et al.   Scientific Reports

Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose

(2016) Robert Jackson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphorylation of Cav1.2 on S1928 uncouples the L‐type Ca2+channel from the β2adrenergic receptor

(2016) Tommaso Patriarchi et al.   EMBO JOURNAL

A critical look at the function of the P2Y11 receptor

(2016) Karin Dreisig et al.   Purinergic Signalling

Purinergic P2Y6receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II–induced hypertension

(2016) Akiyuki Nishimura et al.   Science Signaling

Purinergic P2Y6receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II–induced hypertension

(2016) Akiyuki Nishimura et al.   Science Signaling

Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes

(2015) Khaled S. Abd-Elrahman et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Selective Down-regulation of KV2.1 Function Contributes to Enhanced Arterial Tone during Diabetes

(2015) Madeline Nieves-Cintrón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

(2015) Tran Thi Hien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats

(2015) Paulino Barragán-Iglesias et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

(2015) Rose E Dixon et al.   eLife

Protein Kinase A–Phosphorylated K V 1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries

(2014) Christopher L. Moore et al.   CIRCULATION RESEARCH

Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11receptor, when co-expressed with the P2Y1receptor

(2014) Michael Haas et al.   JOURNAL OF NEUROCHEMISTRY

Role of Spinal P2Y6 and P2Y11 Receptors in Neuropathic Pain in Rats: Possible Involvement of Glial Cells

(2014) Paulino Barragán-Iglesias et al.   Molecular Pain

AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling

(2014) Jonathan G. Murphy et al.   Cell Reports

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca 2+ -Activated K + Channel Remodeling in Hyperglycemia and Diabetes Mellitus

(2013) Matthew A. Nystoriak et al.   CIRCULATION RESEARCH

Pathophysiologic Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes

(2013) R. A. DeFronzo et al.   DIABETES CARE

Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysis

(2013) David Montero et al.   DIABETOLOGIA

Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling

(2013) Mingxu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes Mellitus-Associated Vascular Impairment

(2013) Dimitris Tousoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Competition between α-actinin and Ca2+-Calmodulin Controls Surface Retention of the L-type Ca2+ Channel CaV1.2

(2013) Duane D. Hall et al.   NEURON

Mechanisms of ATP release and signalling in the blood vessel wall

(2012) A. W. Lohman et al.   CARDIOVASCULAR RESEARCH

P2Y Purinoceptors as Potential Emerging Therapeutical Target in Vascular Disease

(2012) Mirjam Schuchardt et al.   CURRENT PHARMACEUTICAL DESIGN

Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation

(2012) A. del Puerto et al.   JOURNAL OF CELL SCIENCE

Purinergic Receptors Regulate Myogenic Tone in Cerebral Parenchymal Arterioles

(2012) Joseph E Brayden et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels

(2012) R. E. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of Normal L-Type Ca 2+ Channel Function During Timothy Syndrome by Ablation of an Anchoring Protein

(2011) Edward P. Cheng et al.   CIRCULATION RESEARCH

AKAP79/150 Signal Complexes in G-Protein Modulation of Neuronal Ion Channels

(2011) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging

(2011) Graham T Dempsey et al.   NATURE METHODS

FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes

(2010) Shubai Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats

(2010) IV Kizub et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased Coupled Gating of L-Type Ca 2+ Channels During Hypertension and Timothy Syndrome

(2010) Manuel F. Navedo et al.   CIRCULATION RESEARCH

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intensive glycemic control and cardiovascular disease: an update

(2010) Aparna Brown et al.   Nature Reviews Cardiology

Regulation of intracerebral arteriolar tone by Kv channels: effects of glucose and PKC

(2009) Stephen V. Straub et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

(2009) Manuel F. Navedo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NF546 [4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene- , '-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

(2009) S. Meis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice

(2008) Farzad Moien-Afshari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AKAP150 Is Required for Stuttering Persistent Ca 2+ Sparklets and Angiotensin II–Induced Hypertension

(2008) Manuel F. Navedo et al.   CIRCULATION RESEARCH

Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Cav1.2 Phosphorylation Site S1928A Mutant Mice

(2008) Toni Lemke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures

(2008) G. Costa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fluorescence nanoscopy by ground-state depletion and single-molecule return

(2008) Jonas Fölling et al.   NATURE METHODS

Hetero-oligomerization of the P2Y11receptor with the P2Y1receptor controls the internalization and ligand selectivity of the P2Y11receptor

(2007) Denise Ecke et al.   BIOCHEMICAL JOURNAL