Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds

Natural history and genotype‐phenotype correlation of pantothenate kinase‐associated neurodegeneration

(2020) Xuting Chang et al.   CNS Neuroscience & Therapeutics

A pantothenate kinase-deficient mouse model reveals a gene expression program associated with brain coenzyme a reduction

(2020) Chitra Subramanian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration

(2020) Paolo Santambrogio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human pantothenate kinase 4 is a pseudo‐pantothenate kinase

(2019) Jiangwei Yao et al.   PROTEIN SCIENCE

Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study

(2019) Thomas Klopstock et al.   LANCET NEUROLOGY

4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

(2019) Suh Young Jeong et al.   EMBO Molecular Medicine

CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

(2019) Roald A Lambrechts et al.   EMBO Molecular Medicine

The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors

(2019) Joy E. Chiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease

(2018) Graziella Ficociello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basal ganglia calcification and novel compound heterozygous mutations in the PANK2 gene in a Chinese boy with classic Pantothenate kinase-associated neurodegeneration

(2018) Xulai Shi et al.   MEDICINE

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation

(2018) Mónica Álvarez-Córdoba et al.   MOLECULAR NEUROBIOLOGY

Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos

(2018) D. Khatri et al.   NEUROMOLECULAR MEDICINE

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease

(2017) Charles Arber et al.   PLoS One

Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

(2017) Ivano Di Meo et al.   Scientific Reports

Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration

(2016) Daniel I Orellana et al.   EMBO Molecular Medicine

Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

(2016) Daniela Zizioli et al.   NEUROBIOLOGY OF DISEASE

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

(2015) J.-P. Lasserre et al.   Disease Models & Mechanisms

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

(2015) Natalia P. Mena et al.   MITOCHONDRION

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients

(2015) Paolo Santambrogio et al.   NEUROBIOLOGY OF DISEASE

Novel gene mutations and clinical features in patients with pantothenate kinase-associated neurodegeneration

(2014) L.-Y. Ma et al.   CLINICAL GENETICS

Clinical, imaging, and molecular findings in a sample of Mexican families with pantothenate kinase-associated neurodegeneration

(2014) H. Morales-Briceño et al.   CLINICAL GENETICS

Fe-S Cluster Biogenesis in Isolated Mammalian Mitochondria

(2014) Alok Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequence Reveals Mutations in CoA Synthase as a Cause of Neurodegeneration with Brain Iron Accumulation

(2013) Sabrina Dusi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model

(2013) Dario Brunetti et al.   BRAIN

The utility of yeast as a tool for cell-based, target-directed high-throughput screening

(2013) J. L. NORCLIFFE et al.   PARASITOLOGY

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

(2013) Virapong Prachayasittikul et al.   Drug Design Development and Therapy

Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties

(2012) A. Campanella et al.   HUMAN MOLECULAR GENETICS

Loss of Cardiolipin Leads to Perturbation of Mitochondrial and Cellular Iron Homeostasis

(2012) Vinay A. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalization of Mammalian Pantothenate Kinases

(2012) Adolfo Alfonso-Pecchio et al.   PLoS One

Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: Lipidome meets Proteome

(2011) Karlheinz Grillitsch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transition metal homeostasis: from yeast to human disease

(2011) Mark R. Bleackley et al.   BIOMETALS

Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration

(2011) M. C. Kruer et al.   BRAIN

A yeast-based assay identifies drugs active against human mitochondrial disorders

(2011) E. Couplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simple is good: yeast models of neurodegeneration

(2010) Sandra Tenreiro et al.   FEMS YEAST RESEARCH

In vivo analysis of mtDNA replication defects in yeast

(2010) Enrico Baruffini et al.   METHODS

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration

(2010) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1

(2009) Judith Olzhausen et al.   CURRENT GENETICS

Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor

(2009) P. Goffrini et al.   HUMAN MOLECULAR GENETICS

Lipoic Acid Synthesis and Attachment in Yeast Mitochondria

(2009) Melissa S. Schonauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

(2008) Roland Lill et al.   Annual Review of Biochemistry