Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration

(2016) Daniel I Orellana et al.   EMBO Molecular Medicine

Coenzyme A: to make it or uptake it?

(2016) Ody C.M. Sibon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

(2016) Daniela Zizioli et al.   NEUROBIOLOGY OF DISEASE

Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms

(2015) Esther Meyer et al.   Annual Review of Genomics and Human Genetics

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy

(2015) Stephen P. Zano et al.   MOLECULAR GENETICS AND METABOLISM

Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis

(2015) Balaji Srinivasan et al.   Nature Chemical Biology

Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins

(2015) Vinayak Agarwal et al.   ORGANIC LETTERS

Coenzyme A, more than ‘just’ a metabolic cofactor

(2014) Balaji Srinivasan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exome Sequence Reveals Mutations in CoA Synthase as a Cause of Neurodegeneration with Brain Iron Accumulation

(2013) Sabrina Dusi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Combination of Pantothenamides with Vanin Inhibitors as a Novel Antibiotic Strategy against Gram-Positive Bacteria

(2013) Patrick A. M. Jansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model

(2013) Dario Brunetti et al.   BRAIN

Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

(2013) Christina Spry et al.   PLoS One

Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

(2013) Marianne de Villiers et al.   ACS Medicinal Chemistry Letters

Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

(2011) Belinda J. Kaskow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired Coenzyme A metabolism affects histone and tubulin acetylation inDrosophilaand human cell models of pantothenate kinase associated neurodegeneration

(2011) Katarzyna Siudeja et al.   EMBO Molecular Medicine

Pantethine Rescues Phosphopantothenoylcysteine Synthetase and Phosphopantothenoylcysteine Decarboxylase Deficiency in Escherichia coli but Not in Pseudomonas aeruginosa

(2011) C. J. Balibar et al.   JOURNAL OF BACTERIOLOGY

Pantothenate Kinase 1 Is Required to Support the Metabolic Transition from the Fed to the Fasted State

(2010) Roberta Leonardi et al.   PLoS One

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration

(2010) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system

(2008) Floris Bosveld et al.   HUMAN MOLECULAR GENETICS