Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins

(2019) Alexandre Desroches et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

(2018) Mable Lam et al.   CELL DEATH AND DIFFERENTIATION

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

(2018) Vitaliya Sagulenko et al.   JOURNAL OF MOLECULAR BIOLOGY

PATs and SNATs: Amino Acid Sensors in Disguise

(2018) Shih-Jung Fan et al.   Frontiers in Pharmacology

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL

(2017) Androulla Elia et al.   Cell Death & Disease

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

(2017) Ya-Kun Zhang et al.   Nature Communications

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues

(2016) J E Seaman et al.   CELL DEATH AND DIFFERENTIATION

Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

(2016) Jianhai Zhang et al.   Oxidative Medicine and Cellular Longevity

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3

(2015) Katia Cailliau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway

(2014) Rosa Martín-Pérez et al.   CANCER RESEARCH

The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity

(2014) Güliz Vanli et al.   CELLULAR SIGNALLING

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

Loss of Cbl-PI3K Interaction Enhances Osteoclast Survival due to p21-Ras Mediated PI3K Activation Independent of Cbl-b

(2014) Naga Suresh Adapala et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of Regions Critical for the Integrity of the TSC1-TSC2-TBC1D7 Complex

(2014) Arthur Jorge Santiago Lima et al.   PLoS One

IL-6 Impairs Myogenic Differentiation by Downmodulation of p90RSK/eEF2 and mTOR/p70S6K Axes, without Affecting AKT Activity

(2014) Michele Pelosi et al.   Biomed Research International

Many roads from mTOR to eIF4F

(2013) Carson C. Thoreen   BIOCHEMICAL SOCIETY TRANSACTIONS

Nutrients and growth factors in mTORC1 activation

(2013) Alejo Efeyan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

(2013) J J Sandow et al.   CELL DEATH AND DIFFERENTIATION

Both PI3K- and mTOR-Signaling Pathways Take Part in CVB3-Induced Apoptosis of HeLa Cells

(2013) Xin Li et al.   DNA AND CELL BIOLOGY

Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis

(2013) Chao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling for biological control and cancer

(2013) Anya Alayev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection

(2013) Nieves Peltzer et al.   PLoS One

Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle

(2013) Mahesh Saqcena et al.   PLoS One

Nutrient signaling to mTOR and cell growth

(2013) Jenna L. Jewell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caspase Substrates and Inhibitors

(2013) M. Poreba et al.   Cold Spring Harbor Perspectives in Biology

Inflammasome-mediated activation of caspase-1 and caspase-6 in primary human neurons

(2012) Vikas Kaushal et al.   Alzheimers & Dementia

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

(2012) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural Features of Caspase-Activating Complexes

(2012) Hyun Ho Park   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-3 Protects Stressed Organs against Cell Death

(2012) H. Khalil et al.   MOLECULAR AND CELLULAR BIOLOGY

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

(2012) Young-Mi Kim et al.   MOLECULAR CELL

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

(2011) Akiko Yamamuro et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

RasGAP-Derived Fragment N Increases the Resistance of Beta Cells towards Apoptosis in NOD Mice and Delays the Progression from Mild to Overt Diabetes

(2011) Natasa Bulat et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

N-Formyl-3,4-methylenedioxy-benzylidene-γ-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells

(2010) Hirofumi Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS

(2010) Li Zhao et al.   CELL CYCLE

Inflammasome and IL-1β-Mediated Disorders

(2010) Hal M. Hoffman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

(2010) M D Lacher et al.   ONCOGENE

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical roles for the TSC-mTOR pathway in β-cell function

(2009) Hiroyuki Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

(2008) Perayot Pamonsinlapatham et al.   BIOCHIMIE

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease

(2008) Y. Tao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress

(2008) J.-P. Upton et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A

(2008) Woen Ping Siu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY