PATs and SNATs: Amino Acid Sensors in Disguise

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Classification Systems of Secondary Active Transporters

(2017) Emelie Perland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A 19-Gene expression signature as a predictor of survival in colorectal cancer

(2016) Nurul Ainin Abdul Aziz et al.   BMC Medical Genomics

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

(2016) Bradley Smith et al.   Cell Reports

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

The SLC36 transporter Pathetic is required for extreme dendrite growth inDrosophilasensory neurons

(2015) Wen-Yang Lin et al.   GENES & DEVELOPMENT

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

(2015) S-J Fan et al.   ONCOGENE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

(2014) Janice D. Thomas et al.   CANCER CELL

Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development

(2013) Qian Wang et al.   JNCI-Journal of the National Cancer Institute

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects

(2013) Helgi B. Schiöth et al.   MOLECULAR ASPECTS OF MEDICINE

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

(2012) Margrét H. Ögmundsdóttir et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

SLC36A4 (hPAT4) Is a High Affinity Amino Acid Transporter When Expressed inXenopus laevisOocytes

(2010) Samyuktha Muralidharan Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

(2010) S Heublein et al.   ONCOGENE

Amino acid sensing and mTOR regulation: inside or out?: Figure 1

(2009) Deborah C.I. Goberdhan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functioning and Evolutionary Significance of Nutrient Transceptors

(2009) J. M. Thevelein et al.   MOLECULAR BIOLOGY AND EVOLUTION

The solute carrier (SLC) complement of the human genome: Phylogenetic classification reveals four major families

(2008) Robert Fredriksson et al.   FEBS LETTERS

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE