Fake It ‘Till You Make It—The Pursuit of Suitable Membrane Mimetics for Membrane Protein Biophysics

Electrophysiological characterization of transport across outer membrane channels from Gram-negative bacteria in presence of lipopolysaccharides (LPS)

(2020) Jiajun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

(2020) Kimmo Rantalainen et al.   Cell Reports

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED

(2020) Lan Zhu et al.   STRUCTURE

Ultrafast structural changes within a photosynthetic reaction centre

(2020) Robert Dods et al.   NATURE

The importance of the membrane for biophysical measurements

(2020) Dror S. Chorev et al.   Nature Chemical Biology

Nanodiscs: A toolkit for membrane protein science

(2020) Stephen G. Sligar et al.   PROTEIN SCIENCE

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

(2019) Shehrazade Jekhmane et al.   Nature Communications

In situ and high‐resolution cryo‐EM structure of a bacterial type VI secretion system membrane complex

(2019) Chiara Rapisarda et al.   EMBO JOURNAL

Nanodiscs for Structural Biology in a Membranous Environment

(2019) Mariko Yokogawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC

(2019) Xiaodong Shi et al.   Nature Communications

High-throughput stability screening for detergent-solubilized membrane proteins

(2019) Vadim Kotov et al.   Scientific Reports

In situ structure determination by subtomogram averaging

(2019) Daniel Castaño-Díez et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-EM structure of the spinach cytochrome b6 f complex at 3.6 Å resolution

(2019) Lorna A. Malone et al.   NATURE

Cardiolipin is an Optimal Phospholipid for the Assembly, Stability, and Proper Functionality of the Dimeric Form of NhaA Na+/H+ Antiporter

(2019) Abraham Rimon et al.   Scientific Reports

Single-Molecule Force Spectroscopy of Transmembrane β-Barrel Proteins

(2018) Johannes Thoma et al.   Annual Review of Analytical Chemistry

Molecular Mechanism of Lipid Nanodisk Formation by Styrene-Maleic Acid Copolymers

(2018) Minmin Xue et al.   BIOPHYSICAL JOURNAL

1 H magic-angle spinning NMR evolves as a powerful new tool for membrane proteins

(2018) Tobias Schubeis et al.   JOURNAL OF MAGNETIC RESONANCE

How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine

(2018) Vilius Kurauskas et al.   Journal of Physical Chemistry Letters

The fine art of integral membrane protein crystallisation

(2018) James Birch et al.   METHODS

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combined 1 H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments

(2018) Lindsay A. Baker et al.   STRUCTURE

POTRA Domains, Extracellular Lid, and Membrane Composition Modulate the Conformational Stability of the β Barrel Assembly Factor BamA

(2018) Johannes Thoma et al.   STRUCTURE

Collisional Lipid Exchange Among DIBMA-Encapsulated Nanodiscs (DIBMALPs)

(2018) Bartholomäus Danielczak et al.   EUROPEAN POLYMER JOURNAL

Structure of the membrane proximal external region of HIV-1 envelope glycoprotein

(2018) Qingshan Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories

(2018) Tomoki Nishimura et al.   Advanced Science

Advancing membrane biology with poly(styrene-co-maleic acid)-based native nanodiscs

(2018) Michael Overduin et al.   EUROPEAN POLYMER JOURNAL

Lipid- and Cholesterol-Mediated Time-Scale-Specific Modulation of the Outer Membrane Protein X Dynamics in Lipid Bilayers

(2018) Lukas Frey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape

(2018) Joshua Hutchings et al.   Nature Communications

Stability of polymersomes with focus on their use as nanoreactors

(2017) Sarah Theresa Poschenrieder et al.   ENGINEERING IN LIFE SCIENCES

Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding

(2017) Bob Schiffrin et al.   JOURNAL OF MOLECULAR BIOLOGY

Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy

(2017) Cecilia Pinto et al.   JOURNAL OF STRUCTURAL BIOLOGY

Local and Global Dynamics in Klebsiella pneumoniae Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution

(2017) Olivier Saurel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tilted, Uninterrupted, Monomeric HIV-1 gp41 Transmembrane Helix from Residual Dipolar Couplings

(2017) Sai Chaitanya Chiliveri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

Imaging modes of atomic force microscopy for application in molecular and cell biology

(2017) Yves F. Dufrêne et al.   Nature Nanotechnology

Structure of outer membrane protein G in lipid bilayers

(2017) Joren S. Retel et al.   Nature Communications

YidC and SecYEG form a heterotetrameric protein translocation channel

(2017) Ilie Sachelaru et al.   Scientific Reports

Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs

(2017) Rodrigo Cuevas Arenas et al.   Scientific Reports

A robust method to screen detergents for membrane protein stabilization, revisited

(2016) Philippe Champeil et al.   ANALYTICAL BIOCHEMISTRY

Micelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics

(2016) Lukas Frey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioinspired polymer vesicles and membranes for biological and medical applications

(2016) Cornelia G. Palivan et al.   CHEMICAL SOCIETY REVIEWS

Optimal Bicelle Sizeqfor Solution NMR Studies of the Protein Transmembrane Partition

(2016) Alessandro Piai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural basis of outer membrane protein insertion by the BAM complex

(2016) Yinghong Gu et al.   NATURE

YidC assists the stepwise and stochastic folding of membrane proteins

(2016) Tetiana Serdiuk et al.   Nature Chemical Biology

A saposin-lipoprotein nanoparticle system for membrane proteins

(2016) Jens Frauenfeld et al.   NATURE METHODS

NMR as a tool to investigate the structure, dynamics and function of membrane proteins

(2016) Binyong Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane insertion of a Tc toxin in near-atomic detail

(2016) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

(2016) J. H. Lee et al.   SCIENCE

Structural basis for membrane anchoring of HIV-1 envelope spike

(2016) J. Dev et al.   SCIENCE

A three-dimensional movie of structural changes in bacteriorhodopsin

(2016) Eriko Nango et al.   SCIENCE

The Structure of the Mouse Serotonin 5-HT 3 Receptor in Lipid Vesicles

(2016) Mikhail Kudryashev et al.   STRUCTURE

How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

(2016) Nagarajan Vaidehi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

(2016) Matthew G. Iadanza et al.   Nature Communications

Tripartite assembly of RND multidrug efflux pumps

(2016) Laetitia Daury et al.   Nature Communications

NMR as a tool to investigate the structure, dynamics and function of membrane proteins

(2016) Binyong Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane insertion of a Tc toxin in near-atomic detail

(2016) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BamA Alone Accelerates Outer Membrane Protein Folding In Vitro through a Catalytic Mechanism

(2015) Ashlee M. Plummer et al.   BIOCHEMISTRY

In Situ Structural Studies of Anabaena Sensory Rhodopsin in the E. coli Membrane

(2015) Meaghan E. Ward et al.   BIOPHYSICAL JOURNAL

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

Rapid automated detergent screening for the solubilization and purification of membrane proteins and complexes

(2015) Violaine Lantez et al.   ENGINEERING IN LIFE SCIENCES

Membrane Protein Complex ExbB4-ExbD1-TonB1from Escherichia coli Demonstrates Conformational Plasticity

(2015) Aleksandr Sverzhinsky et al.   JOURNAL OF BACTERIOLOGY

Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy

(2015) Leonor Morgado et al.   JOURNAL OF BIOMOLECULAR NMR

Solid-state NMR and membrane proteins

(2015) Stanley J. Opella   JOURNAL OF MAGNETIC RESONANCE

Bicelles and Other Membrane Mimics: Comparison of Structure, Properties, and Dynamics from MD Simulations

(2015) Mikkel Vestergaard et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion

(2015) Justyna Kowal et al.   LANGMUIR

Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications

(2015) Kazumi Hiruma-Shimizu et al.   MOLECULAR MEMBRANE BIOLOGY

Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape

(2015) David Alsteens et al.   NATURE METHODS

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins

(2015) Johannes Thoma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Use of Contact Mode Atomic Force Microscopy in Aqueous Medium for Structural Analysis of Spinach Photosynthetic Complexes

(2015) Witchukorn Phuthong et al.   PLANT PHYSIOLOGY

Structure and activity of tryptophan-rich TSPO proteins

(2015) Y. Guo et al.   SCIENCE

Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism

(2015) F. Li et al.   SCIENCE

GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM

(2015) Florian Hauer et al.   STRUCTURE

OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of Pseudomonas aeruginosa

(2015) Iga Kucharska et al.   STRUCTURE

Structure of a bacterial type III secretion system in contact with a host membrane in situ

(2015) Andrea Nans et al.   Nature Communications

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins

(2015) Johannes Thoma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Variation of the Detergent-Binding Capacity and Phospholipid Content of Membrane Proteins When Purified in Different Detergents

(2014) Hüseyin Ilgü et al.   BIOPHYSICAL JOURNAL

Mechanism of Tc toxin action revealed in molecular detail

(2014) Dominic Meusch et al.   NATURE

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

(2014) David Arnlund et al.   NATURE METHODS

High-resolution structure determination by continuous-rotation data collection in MicroED

(2014) Brent L Nannenga et al.   NATURE METHODS

Outer membrane  -barrel protein folding is physically controlled by periplasmic lipid head groups and BamA

(2014) D. Gessmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+channel: The power of native nanodiscs

(2014) Jonas M. Dörr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

(2014)  ukasz Jaremko et al.   SCIENCE

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis

(2014) Thor Seneca Thorsen et al.   STRUCTURE

Extracellular Vesicles: A Platform for the Structure Determination of Membrane Proteins by Cryo-EM

(2014) Tzviya Zeev-Ben-Mordehai et al.   STRUCTURE

Visualizing active membrane protein complexes by electron cryotomography

(2014) Vicki A.M. Gold et al.   Nature Communications

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Influences of Membrane Mimetic Environments on Membrane Protein Structures

(2013) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Lipid Bilayer Composition Can Influence the Orientation of Proteorhodopsin in Artificial Membranes

(2013) Ramya Tunuguntla et al.   BIOPHYSICAL JOURNAL

Structural biology in situ—the potential of subtomogram averaging

(2013) John AG Briggs   CURRENT OPINION IN STRUCTURAL BIOLOGY

Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

(2013) Franz Hagn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Imaging of the Electrostatic Field and Potential Generated by a Transmembrane Protein Pore at Subnanometer Resolution

(2013) Moritz Pfreundschuh et al.   NANO LETTERS

A syringe-like injection mechanism in Photorhabdus luminescens toxins

(2013) Christos Gatsogiannis et al.   NATURE

Three-dimensional electron crystallography of protein microcrystals

(2013) Dan Shi et al.   eLife

Secondary and Tertiary Structure of Bacteriorhodopsin in the SDS Denatured State

(2012) Venkatramanan Krishnamani et al.   BIOCHEMISTRY

OmpA can form folded and unfolded oligomers

(2012) H. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Membrane protein distribution in composite polymer–lipid thin films

(2012) Johannes Thoma et al.   CHEMICAL COMMUNICATIONS

The Magic of Bicelles Lights Up Membrane Protein Structure

(2012) Ulrich H. N. Dürr et al.   CHEMICAL REVIEWS

Solution NMR Studies of Membrane-Protein–Chaperone Complexes

(2012) Björn M. Burmann et al.   CHIMIA

Functional Equilibrium of the KcsA Structure Revealed by NMR

(2012) Shunsuke Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-dependent Generation of Dual Topology for a Membrane Protein

(2012) Mikhail Bogdanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mimicking the cell membrane with block copolymer membranes

(2012) Xiaoyan Zhang et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Can nanotechnology potentiate photodynamic therapy?

(2012) Ying-Ying Huang et al.   Nanotechnology Reviews

Single-Molecule Force Spectroscopy from Nanodiscs: An Assay to Quantify Folding, Stability, and Interactions of Native Membrane Proteins

(2011) Michael Zocher et al.   ACS Nano

Reconstitution of integral membrane proteins into isotropic bicelles with improved sample stability and expanded lipid composition profile

(2011) Emma A. Morrison et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The structural biology of β-barrel membrane proteins: a summary of recent reports

(2011) James W Fairman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystallizing membrane proteins using lipidic bicelles

(2011) Rachna Ujwal et al.   METHODS

Femtosecond X-ray protein nanocrystallography

(2011) Henry N. Chapman et al.   NATURE

Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains

(2011) S. A. Mari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution atomic force microscopy and spectroscopy of native membrane proteins

(2011) Christian A Bippes et al.   REPORTS ON PROGRESS IN PHYSICS

Cell Membranes: The Lipid Perspective

(2011) Ünal Coskun et al.   STRUCTURE

Nonmicellar systems for solution NMR spectroscopy of membrane proteins

(2010) Thomas Raschle et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

(2010) Chie Yoshiura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron cryomicroscopy of membrane proteins: Specimen preparation for two-dimensional crystals and single particles

(2010) Ingeborg Schmidt-Krey et al.   MICRON

High-speed atomic force microscopy shows dynamic molecular processes in photoactivated bacteriorhodopsin

(2010) Mikihiro Shibata et al.   Nature Nanotechnology

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

(2010) Antoine Gautier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound VO motor

(2010) W. C. Y. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Lipid-Dependent Membrane Protein Topogenesis

(2009) William Dowhan et al.   Annual Review of Biochemistry

Bicelles: A natural ‘molecular goniometer’ for structural, dynamical and topological studies of molecules in membranes

(2009) Anna Diller et al.   BIOCHIMIE

Atomic Force Microscopy of Biological Membranes

(2009) Patrick L.T.M. Frederix et al.   BIOPHYSICAL JOURNAL

The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins

(2009) Sebastian Hiller et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dynamics of bacteriorhodopsin 2D crystal observed by high-speed atomic force microscopy

(2009) Hayato Yamashita et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural and Functional Characterization of the Integral Membrane Protein VDAC-1 in Lipid Bilayer Nanodiscs

(2009) Thomas Raschle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane Proteins Solubilized Intact in Lipid Containing Nanoparticles Bounded by Styrene Maleic Acid Copolymer

(2009) Timothy J. Knowles et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Structure and Mechanics of Membrane Proteins

(2008) Andreas Engel et al.   Annual Review of Biochemistry

Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases

(2008) Martin Caffrey   Annual Review of Biophysics

AFM: A Nanotool in Membrane Biology†

(2008) Daniel J. Muller   BIOCHEMISTRY

To flip or not to flip: lipid–protein charge interactions are a determinant of final membrane protein topology

(2008) Mikhail Bogdanov et al.   JOURNAL OF CELL BIOLOGY

Solution State NMR Structure and Dynamics of KpOmpA, a 210 Residue Transmembrane Domain Possessing a High Potential for Immunological Applications

(2008) Marie Renault et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes

(2008) Mohamed Kreir et al.   LAB ON A CHIP

NMR Solution Structure of the Integral Membrane Enzyme DsbB: Functional Insights into DsbB-Catalyzed Disulfide Bond Formation

(2008) Yunpeng Zhou et al.   MOLECULAR CELL

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE

Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers

(2003) Timothy H. Bayburt et al.   PROTEIN SCIENCE