Endoglin: An ‘Accessory’ Receptor Regulating Blood Cell Development and Inflammation

Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy

(2020) Mark J.A. Schoonderwoerd et al.   CLINICAL CANCER RESEARCH

Macrophage development and activation involve coordinated intron retention in key inflammatory regulators

(2020) Immanuel D Green et al.   NUCLEIC ACIDS RESEARCH

The role of TGFβ in hematopoiesis and myeloid disorders

(2019) Alex Bataller et al.   LEUKEMIA

MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells

(2019) Mikel Aristorena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners

(2019) Gallardo-Vara et al.   Cells

Endoglin Trafficking/Exosomal Targeting in Liver Cells Depends on N-Glycosylation

(2019) Meurer et al.   Cells

Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family

(2019) Sun Kyung Kim et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia

(2018) Wade W. Sugden et al.   CURRENT OPINION IN HEMATOLOGY

Surface endoglin (CD105) expression on acute leukemia blast cells: an extensive flow cytometry study of 1002 patients

(2018) Vincenzo Cosimato et al.   LEUKEMIA & LYMPHOMA

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoglin is Highly Expressed in Human Mast Cells

(2018) Suéllen Trentin Brum et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Endothelial cell markers from clinician's perspective

(2017) Jelena Rakocevic et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies

(2017) Claudia Ollauri-Ibáñez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

TGF-β1 Suppresses IL-33–Induced Mast Cell Function

(2017) Victor S. Ndaw et al.   JOURNAL OF IMMUNOLOGY

Detergent-Insoluble Proteome Analysis Revealed Aberrantly Aggregated Proteins in Human Preeclampsia Placentas

(2017) Wanling Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells

(2017) Michala Varejckova et al.   LIFE SCIENCES

ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death

(2017) Michael Rose et al.   MOLECULAR CARCINOGENESIS

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages

(2016) C. R. Edwards et al.   BLOOD

Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity

(2016) Oriane Mauger et al.   NEURON

Global intron retention mediated gene regulation during CD4+T cell activation

(2016) Ting Ni et al.   NUCLEIC ACIDS RESEARCH

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

(2016) June Baik et al.   Nature Communications

Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

(2016) Luisa Ojeda-Fernández et al.   PLoS Genetics

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs

(2015) D. Iskander et al.   BLOOD

Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer

(2015) K O’Leary et al.   BRITISH JOURNAL OF CANCER

Endoglin regulates mural cell adhesion in the circulatory system

(2015) Elisa Rossi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Detained introns are a novel, widespread class of post-transcriptionally spliced introns

(2015) Paul L. Boutz et al.   GENES & DEVELOPMENT

Mast Cells Promote Blood Brain Barrier Breakdown and Neutrophil Infiltration in a Mouse Model of Focal Cerebral Ischemia

(2015) Craig M McKittrick et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Transcription Factor Ehf Is Involved in TGF-β–Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells

(2015) Susumu Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Global gene expression profiling of telangiectasial tissue from patients with hereditary hemorrhagic telangiectasia

(2015) Pernille M. Tørring et al.   MICROVASCULAR RESEARCH

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prospective isolation of human erythroid lineage-committed progenitors

(2015) Yasuo Mori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoglin involvement in integrin-mediated cell adhesion as a putative pathogenic mechanism in hereditary hemorrhagic telangiectasia type 1 (HHT1)

(2015) Elisa Rossi et al.   Frontiers in Genetics

Widespread intron retention in mammals functionally tunes transcriptomes

(2014) Ulrich Braunschweig et al.   GENOME RESEARCH

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

(2014) C. Mallet et al.   HUMAN MOLECULAR GENETICS

Src-mediated Post-translational Regulation of Endoglin Stability and Function Is Critical for Angiogenesis

(2014) Christopher C. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization

(2014) M. Aristorena et al.   JOURNAL OF CELL SCIENCE

Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937

(2014) Francisco J. Blanco et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF- 1 Attenuates Mediator Release and De Novo Kit Expression by Human Skin Mast Cells through a Smad-Dependent Pathway

(2014) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Investigation of Endoglin Wild-Type and Missense Mutant Protein Heterodimerisation Using Fluorescence Microscopy Based IF, BiFC and FRET Analyses

(2014) Tassilo Förg et al.   PLoS One

Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-  signaling pathways

(2013) S. Park et al.   JOURNAL OF CELL SCIENCE

Immunological abnormalities associated with hereditary haemorrhagic telangiectasia

(2013) A. Guilhem et al.   JOURNAL OF INTERNAL MEDICINE

CD105 (Endoglin)-Negative Murine Mesenchymal Stromal Cells Define a New Multipotent Subpopulation with Distinct Differentiation and Immunomodulatory Capacities

(2013) Per Anderson et al.   PLoS One

Microvascular density and mast cells in benign and malignant pheochromocytomas

(2013) Magdalena Białas et al.   POLISH JOURNAL OF PATHOLOGY

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells

(2013) C. K. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor

(2012) Young-Woong Kim et al.   BIOCHEMICAL JOURNAL

A critical role for endoglin in the emergence of blood during embryonic development

(2012) L. Borges et al.   BLOOD

Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration

(2012) E. Rossi et al.   BLOOD

Effect of endoglin overexpression during embryoid body development

(2012) June Baik et al.   EXPERIMENTAL HEMATOLOGY

Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis

(2012) Nam Y. Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential

(2012) A. P. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney

(2012) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence

(2011) Francisco J. Blanco et al.   AGING CELL

Immunophenotypic analysis of erythroid dysplasia and its diagnostic application in myelodysplastic syndromes

(2011) F. Xu et al.   INTERNAL MEDICINE JOURNAL

Immunohistochemical Evaluation of Angiogenesis and Tryptase-positive Mast Cell Infiltration in Periapical Lesions

(2011) Sílvio Carlos Albuquerque Lima et al.   JOURNAL OF ENDODONTICS

Endoplasmic Reticulum Quality Control Is Involved in the Mechanism of Endoglin-Mediated Hereditary Haemorrhagic Telangiectasia

(2011) Bassam R. Ali et al.   PLoS One

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

(2010) L. J. A. C. Hawinkels et al.   CANCER RESEARCH

The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras

(2010) Juan F. Santibanez et al.   CARCINOGENESIS

Deciphering developmental stages of adult myelopoiesis

(2010) Cornelis J. Pronk et al.   CELL CYCLE

Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling

(2010) Steffen K. Meurer et al.   CELLULAR SIGNALLING

Expression of vascular adhesion molecules on human endothelia in autoimmune thyroid disorders

(2010) M. MARAZUELA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endoglin: a 180-kD endothelial cell and macrophage restricted differentiation molecule

(2010) P. J. OCONNELL et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endoglin-Targeted Cancer Therapy

(2010) Ben K. Seon et al.   Current Drug Delivery

Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance

(2009) Simone Post et al.   CARDIOVASCULAR RESEARCH

Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes

(2009) Monique E. Quaedackers et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3–Sp1–KLF6 interaction

(2008) Luisa M. Botella et al.   BIOCHEMICAL JOURNAL

Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro

(2008) Ivan Bochev et al.   CELL BIOLOGY INTERNATIONAL

S-Endoglin Expression Is Induced in Senescent Endothelial Cells and Contributes to Vascular Pathology

(2008) Francisco J. Blanco et al.   CIRCULATION RESEARCH

Identification of an invasion and tumor-suppressing gene,Endoglin(ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma

(2008) Victor Chun Lam Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Endoglin Promotes Transforming Growth Factor β-mediated Smad 1/5/8 Signaling and Inhibits Endothelial Cell Migration through Its Association with GIPC

(2008) Nam Y. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L- and S-endoglin differentially modulate TGF 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

(2008) S. Velasco et al.   JOURNAL OF CELL SCIENCE

Comparison of Macrophage Phenotype Between Decidua Basalis and Decidua Parietalis by Flow Cytometry

(2008) U. Repnik et al.   PLACENTA

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels

(2007) Yoav Yinon et al.   AMERICAN JOURNAL OF PATHOLOGY