Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family

TGF-β2 uses the concave surface of its extended finger region to bind betaglycan’s ZP domain via three residues specific to TGF-β and Inhibin-α

(2019) Morkos A. Henen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

(2019) Daniel S. J. Miller et al.   JOURNAL OF CELL SCIENCE

Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin

(2019) Sun Kyung Kim et al.   STRUCTURE

Structure of the human myostatin precursor and determinants of growth factor latency

(2018) Thomas R Cotton et al.   EMBO JOURNAL

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

(2017) Alan C. Mullen et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Early Vertebrate Development

(2017) Joseph Zinski et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling in Control of Cardiovascular Function

(2017) Marie-José Goumans et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

(2016) Maria M. Villarreal et al.   BIOCHEMISTRY

Biochemistry and Biology of GDF11 and MyostatinResponse to Walker et al

(2016) Ryan G. Walker et al.   CIRCULATION RESEARCH

Activins and Inhibins: Roles in Development, Physiology, and Disease

(2016) Maria Namwanje et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads

(2016) Apirat Chaikuad et al.   Cold Spring Harbor Perspectives in Biology

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Structure and activation of pro-activin A

(2016) Xuelu Wang et al.   Nature Communications

Structure of bone morphogenetic protein 9 procomplex

(2015) Li-Zhi Mi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP gradients: A paradigm for morphogen-mediated developmental patterning

(2015) E. Bier et al.   SCIENCE

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

The DAN family: Modulators of TGF-β signaling and beyond

(2014) Kristof Nolan et al.   PROTEIN SCIENCE

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)

(2013) Uschi Diestel et al.   PLoS One

Structure of the Alk1 Extracellular Domain and Characterization of Its Bone Morphogenetic Protein (BMP) Binding Properties

(2012) Pardeep Mahlawat et al.   BIOCHEMISTRY

βarrestin2 interacts with TβRII to regulate Smad-dependent and Smad-independent signal transduction

(2012) Sarah McLean et al.   CELLULAR SIGNALLING

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily

(2012) Andrew P. Hinck   FEBS LETTERS

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Insights into Endoglin Ligand Recognition and Binding

(2012) Aaron Alt et al.   PLoS One

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-  binding

(2011) S. J. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

(2010) L. J. A. C. Hawinkels et al.   CANCER RESEARCH

Roles for the type III TGF-β receptor in human cancer

(2010) Catherine E. Gatza et al.   CELLULAR SIGNALLING

Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily

(2010) Sergei Radaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Betaglycan has Two Independent Domains Required for High Affinity TGF-β Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor

(2009) Valentín Mendoza et al.   BIOCHEMISTRY

TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs†

(2009) Jason Baardsnes et al.   BIOCHEMISTRY

Emerging role of bone morphogenetic proteins in angiogenesis

(2009) Laurent David et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor

(2008) Kellye C. Kirkbride et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Inhibin A Biological Activity by Alterations in the Binding Site for Betaglycan

(2008) Yogeshwar Makanji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL