Myeloperoxidase-Derived 2-Chlorohexadecanal Is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro

2-Chlorofatty acids are biomarkers of sepsis mortality and mediators of barrier dysfunction in rats

(2020) Daniel P Pike et al.   JOURNAL OF LIPID RESEARCH

Neutrophil-Mediated Cardiac Damage After Acute Myocardial Infarction: Significance of Defining a New Target Cell Type for Developing Cardioprotective Drugs

(2020) Mary El Kazzi et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease

(2019) Marju Puurand et al.   Cells

On the role of tubulin, plectin, desmin and vimentin in the regulation of mitochondrial energy fluxes in muscle cells

(2019) Kati Mado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An update on lipid oxidation and inflammation in cardiovascular diseases

(2019) Shanshan Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor

(2018) Sanjna L. Surya et al.   ACS Chemical Biology

The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties

(2018) Elisa N.D. Palladino et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators

(2018) Jesse R. Poganik et al.   BIOESSAYS

2-Chlorofatty acids: Lipid mediators of neutrophil extracellular trap formation

(2018) Elisa N.D. Palladino et al.   JOURNAL OF LIPID RESEARCH

Chlorinated Lipids Elicit Inflammatory Responses In Vitro and In Vivo

(2018) Hong Yu et al.   SHOCK

2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells

(2018) Eva Bernhart et al.   Redox Biology

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

Pharmacological inhibition of serine palmitoyl transferase and sphingosine kinase-1/-2 inhibits Merkel Cell Carcinoma cell proliferation

(2018) Vishwanath Kumble Bhat et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles

(2018) Xuyu Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1

(2017) Martina Paumann-Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal

(2016) Christoph Nusshold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myeloperoxidase: Bridging the gap in neurodegeneration

(2016) R.S. Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

(2016) Nathaniel Teng et al.   REDOX REPORT

Current Murine Models of Sepsis

(2016) Anthony J. Lewis et al.   Surgical Infections

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

(2015) Ana I. Casas et al.   ANTIOXIDANTS & REDOX SIGNALING

Myeloperoxidase-dependent Lipid Peroxidation Promotes the Oxidative Modification of Cytosolic Proteins in Phagocytic Neutrophils

(2015) Rachel P. Wilkie-Grantham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of glutathione adducts of α-chlorofatty aldehydes produced in activated neutrophils

(2015) Mark A. Duerr et al.   JOURNAL OF LIPID RESEARCH

Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

(2014) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1

(2014) Daniel W. Neef et al.   Cell Reports

Alpha-Chlorofatty Acid Accumulates in Activated Monocytes and Causes Apoptosis Through Reactive Oxygen Species Production and Endoplasmic Reticulum Stress

(2013) Wen-yi Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function

(2013) William B. Rizzo   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise

(2012) James D. West et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phloretin ameliorates 2-chlorohexadecanal-mediated brain microvascular endothelial cell dysfunction in vitro

(2012) Andreas Üllen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microbicidal Activity of Vascular Peroxidase 1 in Human Plasma via Generation of Hypochlorous Acid

(2012) Hong Li et al.   INFECTION AND IMMUNITY

Small heat shock proteins in redox metabolism: Implications for cardiovascular diseases

(2012) Elisabeth S. Christians et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The inflammatory response in sepsis

(2012) Markus Bosmann et al.   TRENDS IN IMMUNOLOGY

Mitochondria–cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells

(2011) Rita Guzun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Formation and Signaling Actions of Electrophilic Lipids

(2011) Francisco J. Schopfer et al.   CHEMICAL REVIEWS

Toll-Like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Signaling

(2011) Joel Schilling et al.   Circulation-Heart Failure

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Lipopolysaccharide and sepsis-associated myocardial dysfunction

(2011) Tara M Balija et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo

(2010) Andreas Üllen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro

(2010) Christoph Nusshold et al.   FREE RADICAL BIOLOGY AND MEDICINE

ω-Oxidation of α-Chlorinated Fatty Acids

(2010) Viral V. Brahmbhatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Harmful Role of C5a on Innate Immunity in Sepsis

(2010) Peter A. Ward   Journal of Innate Immunity

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

(2010) Volker Rudolph et al.   NATURE MEDICINE

Sepsis and the heart

(2009) J.D. Hunter et al.   BRITISH JOURNAL OF ANAESTHESIA

Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxesThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).

(2009) Claire Monge et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal

(2009) Dhanalakshmi S. Anbukumar et al.   JOURNAL OF LIPID RESEARCH

Vimentin supports mitochondrial morphology and organization

(2008) Ho Lam Tang et al.   BIOCHEMICAL JOURNAL

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE