Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents

Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis

(2020) Hyocheol Bae et al.   Marine Drugs

Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase

(2020) Chantal Désirée Daub et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells

(2020) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Degradation of different molecular weight fucoidans and their inhibition of TGF-β1 induced epithelial–mesenchymal transition in mouse renal tubular epithelial cells

(2020) Xiaosong Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

(2020) M. Ajanth Praveen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fucoidan (FUC) and galactooligosaccharides (GOS) ameliorate high-fat-diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism

(2019) Qichao Chen et al.   NUTRITION

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

(2019) Yu Wang et al.   Marine Drugs

Marine natural products as source of new drugs: a patent review (2015-2018)

(2019) Pravin Shinde et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells

(2019) Xinjia He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fucoidans from brown algae Laminaria longipes and Saccharina cichorioides: Structural characteristics, anticancer and radiosensitizing activity in vitro

(2019) Roza V. Usoltseva et al.   CARBOHYDRATE POLYMERS

Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice

(2019) Yang Cheng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll of Undaria pinnatifida in Cyclophosphamide-Induced Immunosuppressed Mice

(2019) Hee Joon Yoo et al.   Marine Drugs

Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression

(2019) Yong-Seok Han et al.   Marine Drugs

Evaluation of the Immunomodulatory Effects of Fucoidan Derived from Cladosiphon Okamuranus Tokida in Mice

(2019) Makoto Tomori et al.   Marine Drugs

Therapies from Fucoidan: New Developments

(2019) Fitton et al.   Marine Drugs

Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma

(2019) Srimanta Patra et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of a combined fucoidan and traditional Chinese medicine formula on hyperglycaemia and diabetic nephropathy in a type II diabetes mellitus rat model

(2019) Yongbo Peng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidans: The importance of processing on their anti-tumoral properties

(2019) M.D. Torres et al.   Algal Research-Biomass Biofuels and Bioproducts

Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities

(2018) Eric Lahrsen et al.   CARBOHYDRATE POLYMERS

Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy

(2018) Yao Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Immune activation of RAW264.7 macrophages by low molecular weight fucoidan extracted from New Zealand Undaria pinnatifida

(2018) Bi Decheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fucoidan Extracted from Undaria pinnatifida: Source for Nutraceuticals/Functional Foods

(2018) Yu Zhao et al.   Marine Drugs

A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice

(2018) Shan Li et al.   Food & Function

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

(2018) Li Zhang et al.   Aging and Disease

Primary structure and anticoagulant activity of fucoidan from the sea cucumber Holothuria polii

(2018) Mohamed Ben Mansour et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Comparison of structure and in vitro anticancer activity of native and modified fucoidans from Sargassum feldmannii and S. duplicatum

(2018) Roza V. Usoltseva et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats

(2017) Dongying Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes

(2017) Hong-Ting Lin et al.   Marine Drugs

Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice

(2017) Hengyun Wei et al.   Marine Drugs

Fucoidan as bio-functional molecule: Insights into the anti-inflammatory potential and associated molecular mechanisms

(2017) Abdul Rehman Phull et al.   Journal of Functional Foods

Estimating the prevalence, hospitalisation and mortality from type 2 diabetes mellitus in Nigeria: a systematic review and meta-analysis

(2017) Davies Adeloye et al.   BMJ Open

Effect of Qianghuo Erhuang Decoction on T Regulatory and T Helper 17 Cells in Treatment of Adjuvant-induced Arthritis in Rats

(2017) Can Qian et al.   Scientific Reports

Fucoidan Induces Cell Aggregation and Apoptosis in Osteosarcoma MG-63 Cells

(2016) Hyeseon Kim et al.   Animal Cells and Systems

Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway

(2016) Min Ho Han et al.   DRUG DEVELOPMENT RESEARCH

In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii

(2016) Subramaniam Dinesh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy

(2016) Yingjie Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In vitro and in vivo hypoglycemic effects of brown algal fucoidans

(2016) Xindi Shan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression

(2016) Gang-Sik Choo et al.   Marine Drugs

Prevalence and prevention of cardiovascular disease and diabetes mellitus

(2016) Pitchai Balakumar et al.   PHARMACOLOGICAL RESEARCH

Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds

(2016) Gati Krushna Panigrahi et al.   TOXICOLOGY LETTERS

Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice

(2016) Meng-Chuan Chen et al.   Oncotarget

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

(2016) Szu-Yuan Wu et al.   Journal of Cancer

Global burden of cancers attributable to infections in 2012: a synthetic analysis

(2016) Martyn Plummer et al.   Lancet Global Health

Anti-HIV activity of fucoidans from three brown seaweed species

(2015) Thanh Thi Thu Thuy et al.   CARBOHYDRATE POLYMERS

Advances in the Research and Development of Natural Health Products as Main Stream Cancer Therapeutics

(2015) Pamela Ovadje et al.   Evidence-based Complementary and Alternative Medicine

Declining incidence of sudden cardiac death from 1990–2010 in a general middle-aged and elderly population: The Rotterdam Study

(2015) Maartje N. Niemeijer et al.   HEART RHYTHM

Fucoidan delays apoptosis and induces pro-inflammatory cytokine production in human neutrophils

(2015) Jun-O Jin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan – A α-d-glucosidase inhibitor from Sargassum wightii with relevance to type 2 diabetes mellitus therapy

(2015) T. Vinoth Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-κB signaling pathway in vivo and in vitro

(2015) YAN WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Defeating AIDS—advancing global health

(2015) Peter Piot et al.   LANCET

Therapies from Fucoidan: An Update

(2015) Janet Fitton et al.   Marine Drugs

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species

(2015) CHUNMEI WEI et al.   Molecular Medicine Reports

Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways

(2015) YONG-SEOK HAN et al.   Molecular Medicine Reports

Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer

(2015) D. Pádua et al.   Phytochemistry Letters

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Therapeutic Effects of Fucoidan in 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's disease: Role of NADPH oxidase-1

(2014) Fei-Long Zhang et al.   CNS Neuroscience & Therapeutics

Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals

(2014) Ioannis Giavasis   CURRENT OPINION IN BIOTECHNOLOGY

Effect of Fucoidan Administration on Insulin Secretion and Insulin Resistance in Overweight or Obese Adults

(2014) Diana M. Hernández-Corona et al.   JOURNAL OF MEDICINAL FOOD

Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats

(2014) Wentong Cui et al.   LABORATORY INVESTIGATION

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

(2014) Jing Wang et al.   Marine Drugs

Intestinal Absorption of Fucoidan Extracted from the Brown Seaweed, Cladosiphon okamuranus

(2014) Takeaki Nagamine et al.   Marine Drugs

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

(2014) Mariana Barbosa et al.   Marine Drugs

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

(2014) Jun-O Jin et al.   PLoS One

Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice

(2014) Shiwei Hu et al.   Journal of Functional Foods

Global causes of maternal death: a WHO systematic analysis

(2014) Lale Say et al.   Lancet Global Health

Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer

(2013) Brenda K. Edwards et al.   CANCER

Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor

(2013) Wenzhe Yang et al.   EXPERIMENTAL EYE RESEARCH

AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells

(2013) Tae-Min Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells

(2013) Amal M. Banafa et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Fucoidans as Potential Inhibitors of HIV-1

(2013) Maria Prokofjeva et al.   Marine Drugs

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

(2013) Hyun Park et al.   Marine Drugs

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

(2013) HANG-EUN LEE et al.   Experimental and Therapeutic Medicine

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

(2012) Kui-Jin Kim et al.   FITOTERAPIA

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

(2012) Kazuo Azuma et al.   Marine Drugs

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings

(2012) Seema Patel   3 Biotech

Enzyme-assisted extraction of Ecklonia cava fermented with Lactobacillus brevis and isolation of an anti-inflammatory polysaccharide

(2012) Won-Woo Lee et al.   ALGAE

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

(2011) Svetlana Ermakova et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Algal fucoidan: structural and size-dependent bioactivities and their perspectives

(2011) V. K. Morya et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008

(2011) Vanya Delgermaa et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review

(2011) W.A.J.P. Wijesinghe et al.   CARBOHYDRATE POLYMERS

Potential pharmacological applications of polyphenolic derivatives from marine brown algae

(2011) Noel Vinay Thomas et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats

(2011) Yonglin Gao et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

It's not about the Bike, It's About the Pedaling

(2011) Jay L. Alberts et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Immunostimulatory Activity of Fucoidan from the Brown AlgaFucus evanescens: Role of Sulfates and Acetates

(2011) Stanislav R. Khil’chenko et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Neuroprotective Effects of Marine Algae

(2011) Ratih Pangestuti et al.   Marine Drugs

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Therapies from Fucoidan; Multifunctional Marine Polymers

(2011) Janet Helen Fitton   Marine Drugs

Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed

(2011) Diego O. Croci et al.   PLoS One

Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways

(2011) Zhongyuan Zhang et al.   PLoS One

Inflammation in diabetic retinopathy

(2011) Johnny Tang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Bioactive potential and possible health effects of edible brown seaweeds

(2011) Shilpi Gupta et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells

(2010) Yaling Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of a Fucoidan-Specific Antibody and Measurement of Fucoidan in Serum and Urine by Sandwich ELISA

(2010) Yoshiharu TOKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucoidan present in brown algae induces apoptosis of human colon cancer cells

(2010) Eun Ji Kim et al.   BMC GASTROENTEROLOGY

Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

(2010) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae

(2010) Isuru Wijesekara et al.   CARBOHYDRATE POLYMERS

Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima

(2010) Maria I. Bilan et al.   CARBOHYDRATE RESEARCH

Structural studies on a novel fucogalactan sulfate extracted from the brown seaweed Laminaria japonica

(2010) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes

(2010) Gurvan Michel et al.   NEW PHYTOLOGIST

Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression inin VitroGut Inflammation

(2009) Masashi MIZUNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Fucoidan protects against dopaminergic neuron death in vivo and in vitro

(2009) Dingzhen Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structural characteristics and in vitro macrophage activation of acetyl fucoidan from Cladosiphon okamuranus

(2009) Takeshi Teruya et al.   GLYCOCONJUGATE JOURNAL

Fucoidan increases TNF-α-induced MMP-9 secretion in monocytic cell line U937

(2009) Sun Jintang et al.   INFLAMMATION RESEARCH

Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells

(2009) Yumi Yamasaki-Miyamoto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT, AP-1 and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-α- and IFN-γ-stimulated C6 glioma cells☆

(2009) Hang Do et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

(2008) Na Yeon Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells

(2008) Meixiang Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Antiretroviral activity of fucoidans extracted from the brown seaweedAdenocystis utricularis

(2008) Juan Trinchero et al.   PHYTOTHERAPY RESEARCH