Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory

(2018) Moritz M. Gaidt et al.   JOURNAL OF MOLECULAR BIOLOGY

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor

(2018) Nicole Stichling et al.   PLoS Pathogens

Highly Pathogenic H5N1 Influenza A Virus Spreads Efficiently in Human Primary Monocyte-Derived Macrophages and Dendritic Cells

(2018) Veera Westenius et al.   Frontiers in Immunology

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

(2018) Maria Bottermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Reassessing the Evolutionary Importance of Inflammasomes

(2016) Vivien I. Maltez et al.   JOURNAL OF IMMUNOLOGY

Virus and Host Mechanics Support Membrane Penetration and Cell Entry

(2016) Urs F. Greber   JOURNAL OF VIROLOGY

Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function

(2016) Shauna A. Marvin et al.   JOURNAL OF VIROLOGY

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

(2016) Andrew J. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells

(2016) Karsten Eichholz et al.   PLoS Pathogens

Antibody-antigen kinetics constrain intracellular humoral immunity

(2016) Maria Bottermann et al.   Scientific Reports

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Response of host inflammasomes to viral infection

(2015) I-Yin Chen et al.   TRENDS IN MICROBIOLOGY

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

(2015) Ruth E. Watkinson et al.   PLoS Pathogens

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Macrophage Paradox

(2014) Jordan V. Price et al.   IMMUNITY

Late Endosomal Trafficking of Alternative Serotype Adenovirus Vaccine Vectors Augments Antiviral Innate Immunity

(2014) J. E. Teigler et al.   JOURNAL OF VIROLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Antimicrobial functions of inflammasomes

(2013) Kaiwen W Chen et al.   CURRENT OPINION IN MICROBIOLOGY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Intracellular antibody receptor TRIM21 prevents fatal viral infection

(2013) M. Vaysburd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

(2013) Daniel T. MacLeod et al.   Nature Communications

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

(2012) W. A. McEwan et al.   JOURNAL OF VIROLOGY

Influenza Virus A Infection of Human Monocyte and Macrophage Subpopulations Reveals Increased Susceptibility Associated with Cell Differentiation

(2012) Marieke A. Hoeve et al.   PLoS One

Proinflammatory Cytokine Response and Viral Replication in Mouse Bone Marrow Derived Macrophages Infected with Influenza H1N1 and H5N1 Viruses

(2012) Renee W. Y. Chan et al.   PLoS One

AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization

(2012) F. Hauler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome

(2011) A.U. Barlan et al.   VIROLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response

(2009) A. K. Zaiss et al.   JOURNAL OF IMMUNOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE