Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
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Title
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
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Journal
HUMAN REPRODUCTION UPDATE
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2020-10-31
DOI
10.1093/humupd/dmaa053
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- Overexpression of hypoxia-inducible factor 1α induces migration and invasion through Notch signaling
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- Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia
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- Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study
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- Strong hypoxia reduces leptin synthesis in purified primary human trophoblasts
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- Low molecular weight heparin therapy during pregnancy is associated with elevated circulatory levels of placental growth factor
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- Animal models of fetal growth restriction: Considerations for translational medicine
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- Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes
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- The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1
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- Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia
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- Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial
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- Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction
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- Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development
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- Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression
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- The Human Placenta Project: Placental structure, development, and function in real time
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- Hypoxia and the Anticoagulants Dalteparin and Acetylsalicylic Acid Affect Human Placental Amino Acid Transport
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- The balancing act – PPAR-γ’s roles at the maternal-fetal interface
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- XIAP protein is induced by placenta growth factor (PLGF) and decreased during preeclampsia in trophoblast cells
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- Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)
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- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
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- The therapeutic potential of antioxidants, ER chaperones, NO and H2S donors, and statins for treatment of preeclampsia
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- The placental pursuit for an adequate oxidant balance between the mother and the fetus
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- Reduced Cystathionine γ-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies
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- Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia
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- Maternal and Fetoplacental Hypoxia Do Not Alter Circulating Angiogenic Growth Effectors During Human Pregnancy1
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- Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta-analysis
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- Heme oxygenase in pregnancy and preeclampsia
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- Reduced Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Preeclamptic Placentas Is Associated With Decreased PPARγ but Increased PPARα Expression
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- Hypoxia alters the epigenetic profile in cultured human placental trophoblasts
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- VEGF, PIGF and HIF-1α in placentas of early- and late-onset pre-eclamptic patients
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- Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction
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- MicroRNAs: are they the missing link between hypoxia and pre-eclampsia?
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- Trophoblast invasion and oxygenation of the placenta: measurements versus presumptions
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- Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis
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- Reversible effects of oxygen partial pressure on genes associated with placental angiogenesis and differentiation in primary-term cytotrophoblast cell culture
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- Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction
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- Evidence for extraplacental sources of circulating angiogenic growth effectors in human pregnancy
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- Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia
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- Increased NFAT5 expression stimulates transcription of Hsp70 in preeclamptic placentas
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- Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in vivo and the human trophoblast line BeWo in vitro
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- Reduced Syncytin-1 Expression Levels in Placental Syndromes Correlates with Epigenetic Hypermethylation of the ERVW-1 Promoter Region
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- Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via Enhanced Placental Glucose Transport Mechanisms
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- Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes
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- Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy
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- PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia
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- Differential expression of beta-catenin and dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study
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- Hypoxia Induces Autophagy in Primary Human Trophoblasts
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- Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude
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- The vascular endothelial growth factor family in adverse pregnancy outcomes
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- Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model
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- Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia
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- Viability of primary term cytotrophoblast cell culture in normoxia and hypoxia
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- Evolution of Placental Function in Mammals: The Molecular Basis of Gas and Nutrient Transfer, Hormone Secretion, and Immune Responses
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- Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?
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- Oxygen delivery and fetal-placental growth: Beyond a question of supply and demand?
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- MIR-210 modulates mitochondrial respiration in placenta with preeclampsia
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- Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
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- Increased Autophagy in Placentas of Intrauterine Growth-Restricted Pregnancies
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- Protective Effect of N-acetylcysteine on Liver Damage During Chronic Intrauterine Hypoxia in Fetal Guinea Pig
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- Key questions and answers about pregnancy-associated plasma protein-A
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- Role of oxidative stress and antioxidant supplementation in pregnancy disorders
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- Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta
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- The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
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- High Altitude During Pregnancy
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- Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease
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- Trophoblast apoptosis in human term placentas from pregnancies complicated with idiopathic intrauterine growth retardation
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- Review: Leptin gene expression in the placenta – Regulation of a key hormone in trophoblast proliferation and survival
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- Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts
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- Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo)
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- Reduced Expression of Both Syncytin 1 and Syncytin 2 Correlates With Severity of Preeclampsia
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- mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
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- The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
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- Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
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- Hypoxia. 2. Hypoxia regulates cellular metabolism
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- Placental Apoptosis in Health and Disease
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- Effect of Hypoxia on Endothelial Nitric Oxide Synthase, NO Production, Intracellular Survival Signaling (p-ERK1/2 and p-AKT) and Apoptosis in Human Term Trophoblast
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- Reduced placental prolyl hydroxylase 3 mRNA expression in pregnancies affected by fetal growth restriction
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- Mechanisms of angiogenesis: Role of hydrogen sulphide
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- Regulation of the Matricellular Proteins CYR61 (CCN1) and NOV (CCN3) by Hypoxia-Inducible Factor-1α and Transforming-Growth Factor-β3 in the Human Trophoblast
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- The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth
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- First-Trimester Maternal Serum a Disintegrin and Metalloprotease 12 (ADAM12) and Adverse Pregnancy Outcome
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- Expression of heat shock protein 70 and endothelial nitric oxide synthase in placental tissue of preeclamptic and intrauterine growth-restricted pregnancies
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- Biological functions of hCG and hCG-related molecules
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- Do Anti-angiogenic or Angiogenic Factors Contribute to the Protection of Birth Weight at High Altitude Afforded by Andean Ancestry?
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- Early fetal growth, PAPP-A and free β-hCG in relation to risk of delivering a small-for-gestational age infant
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- l-Arginine treatment for severe vascular fetal intrauterine growth restriction: A randomized double-bind controlled trial
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- The Impact of First-Trimester Serum Free β-Human Chorionic Gonadotropin and Pregnancy-Associated Plasma Protein A on the Diagnosis of Fetal Growth Restriction and Small for Gestational Age Infant
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- Mechanism of Hypoxia-induced GCM1 Degradation
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- Differential Regulation of Human PlGF Gene Expression in Trophoblast and Nontrophoblast Cells by Oxygen Tension
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- Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy
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- Autophagy-Related Proteins, LC3 and Beclin-1, in Placentas From Pregnancies Complicated by Preeclampsia
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- Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels
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- Placental Productions and Expressions of Soluble Endoglin, Soluble fms-Like Tyrosine Kinase Receptor-1, and Placental Growth Factor in Normal and Preeclamptic Pregnancies
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- Role of nuclear receptors and their ligands in human trophoblast invasion
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