The role of Sirtuin1–PPARγ axis in placental development and function

Sirtuin1 is required for proper trophoblast differentiation and placental development in mice

(2018) Kanaga Arul Nambi Rajan et al.   PLACENTA

Trophoblast lineage specification, differentiation and their regulation by oxygen tension

(2017) Ching-Wen Chang et al.   JOURNAL OF ENDOCRINOLOGY

Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation

(2017) Autumn J. Broady et al.   PLACENTA

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment

(2017) Natalie J. Hannan et al.   Scientific Reports

The role of inflammation in the pathology of preeclampsia

(2016) A. C. Harmon et al.   CLINICAL SCIENCE

Rosiglitazone pretreatment protects against lipopolysaccharide-induced fetal demise through inhibiting placental inflammation

(2016) Qing-Li Bo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth

(2016) Evangelina Capobianco et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Maternal obesity and sex-specific differences in placental pathology

(2016) Sandra M. Leon-Garcia et al.   PLACENTA

Effect of Human Umbilical Cord Mesenchymal Stem Cell Transplantation in a Rat Model of Preeclampsia

(2016) Lei-Lei Wang et al.   Reproductive Sciences

The placenta is the center of the chronic disease universe

(2015) Kent L. Thornburg et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Why is placentation abnormal in preeclampsia?

(2015) Susan J. Fisher   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

What is the placenta?

(2015) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice

(2015) Liping Qiao et al.   DIABETES

Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia

(2015) Keiichi Matsubara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

(2015) Glenn Simmons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A systematic review of placental pathology in maternal diabetes mellitus

(2015) J. Huynh et al.   PLACENTA

Visfatin/Nampt and SIRT1

(2015) Pai-Jong Stacy Tsai et al.   Reproductive Sciences

Hyperglycemia impairs cytotrophoblast function via stress signaling

(2014) Chase R. Cawyer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Immunological Modes of Pregnancy Loss: Inflammation, Immune Effectors, and Stress

(2014) Joanne Kwak-Kim et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Maternal micronutrients, omega-3 fatty acids, and placental PPARγ expression

(2014) Akshaya P. Meher et al.   Applied Physiology Nutrition and Metabolism

Signaling pathways in mouse and human trophoblast differentiation: a comparative review

(2014) Francesca Soncin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resveratrol and Its Metabolites Bind to PPARs

(2014) Enrica Calleri et al.   CHEMBIOCHEM

Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats

(2014) Yanfen Zou et al.   MOLECULES

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

PPAR-γRegulates Trophoblast Differentiation in the BeWo Cell Model

(2014) Khrystyna Levytska et al.   PPAR Research

c-Met-Dependent Multipotent Labyrinth Trophoblast Progenitors Establish Placental Exchange Interface

(2013) Masaya Ueno et al.   DEVELOPMENTAL CELL

Reduced Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Preeclamptic Placentas Is Associated With Decreased PPARγ but Increased PPARα Expression

(2013) Ping He et al.   ENDOCRINOLOGY

Peroxisome proliferator-activated receptor-gamma (PPARγ) is down regulated in trophoblast cells of gestational diabetes mellitus (GDM) and in trophoblast tumour cells BeWo in vitro after stimulation with PPARγ agonists

(2013) Julia Knabl et al.   JOURNAL OF PERINATAL MEDICINE

Gene Expression Analysis of the Microdissected Trophoblast Layer of Human Placenta after the Spontaneous Onset of Labor

(2013) Soo Hyun Kim et al.   PLoS One

Hypoxia and Trophoblast Differentiation: A Key Role for PPARγ

(2013) Veronique Tache et al.   STEM CELLS AND DEVELOPMENT

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network

(2012) Tali Shalom-Barak et al.   DEVELOPMENTAL BIOLOGY

Effects of Reduced Gcm1 Expression on Trophoblast Morphology, Fetoplacental Vascularity, and Pregnancy Outcomes in Mice

(2012) Shannon A. Bainbridge et al.   HYPERTENSION

Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?

(2012) J.L. James et al.   PLACENTA

Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta

(2011) Melissa J. Cudmore et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

SIRT1, metabolism and cancer

(2011) John R.P. Knight et al.   CURRENT OPINION IN ONCOLOGY

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity

(2011) Véronique Taché et al.   HUMAN PATHOLOGY

Evidence Implicating Peroxisome Proliferator-Activated Receptor-γ in the Pathogenesis of Preeclampsia

(2011) Fergus P. McCarthy et al.   HYPERTENSION

Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner

(2011) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Is a Novel Regulator of Key Pathways of Human Labor1

(2010) Martha Lappas et al.   BIOLOGY OF REPRODUCTION

Brown vs white adipocytes: The PPARγ coregulator story

(2010) Arjen Koppen et al.   FEBS LETTERS

Energy Restriction as an Antitumor Target of Thiazolidinediones

(2010) Shuo Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: Gestational diabetes mellitus, intrauterine growth restriction and preeclampsia

(2010) S.J. Holdsworth-Carson et al.   PLACENTA

Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast

(2009) D Baczyk et al.   CELL DEATH AND DIFFERENTIATION

Expression and Regulation by PPARγ of hCG α- and β-subunits: Comparison between Villous and Invasive Extravillous Trophoblastic Cells☆

(2009) K. Handschuh et al.   PLACENTA

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Before They Were Fat: Adipocyte Progenitors

(2008) Kye Won Park et al.   Cell Metabolism

Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

(2008) C. Munaut et al.   HUMAN REPRODUCTION