ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts

Urinary ADAM12 and MMP-9/NGAL Complex Detect the Presence of Gastric Cancer

(2015) T. Shimura et al.   Cancer Prevention Research

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion

(2015) M Aghababaei et al.   CELL DEATH AND DIFFERENTIATION

Large Scale Aggregate Microarray Analysis Reveals Three Distinct Molecular Subclasses of Human Preeclampsia

(2015) Katherine Leavey et al.   PLoS One

Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading1

(2014) Katarzyna Biadasiewicz et al.   BIOLOGY OF REPRODUCTION

Abnormal blood biomarkers in early pregnancy are associated with preeclampsia: a meta-analysis

(2014) Rebecca E. Allen et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts

(2014) P. Velicky et al.   MOLECULAR HUMAN REPRODUCTION

IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells

(2014) Erin J Crosley et al.   Reproductive Biology and Endocrinology

First Trimester Biomarkers in the Prediction of Later Pregnancy Complications

(2014) Stefan C. Kane et al.   Biomed Research International

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins

(2013) Camilla Fröhlich et al.   BIOCHEMICAL JOURNAL

Pregnancy-associated Plasma Protein A (PAPP-A) Modulates the Early Developmental Rate in Zebrafish Independently of Its Proteolytic Activity

(2013) Kasper Kjaer-Sorensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

(2013) Begoña Díaz et al.   JOURNAL OF CELL BIOLOGY

ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth

(2013) R. Albrechtsen et al.   JOURNAL OF CELL SCIENCE

A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development

(2013) M. Aghababaei et al.   MOLECULAR HUMAN REPRODUCTION

Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction

(2013) V. Plaks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia

(2013) Kate Macintire et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

First-Trimester Levels of Pregnancy-Associated Plasma Protein A2 (PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia

(2013) Erin J. Crosley et al.   Reproductive Sciences

Significance of IGFBP-4 in the Development of Fetal Growth Restriction

(2012) Qing Qiu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

Deep placentation

(2011) R. Pijnenborg et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

ADAM12 Transmembrane and Secreted Isoforms Promote Breast Tumor Growth

(2011) Roopali Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease-Disintegrin ADAM12 Expression Is Regulated by Notch Signaling via MicroRNA-29

(2011) Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo)

(2011) Pamela K Wagner et al.   Reproductive Biology and Endocrinology

Transforming Growth Factor-β (TGFβ) Receptors I/II Differentially Regulate TGFβ1 and IGF-Binding Protein-3 Mitogenic Effects in the Human Placenta

(2010) Karen Forbes et al.   ENDOCRINOLOGY

Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity

(2010) Reidar Albrechtsen et al.   EXPERIMENTAL CELL RESEARCH

The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth

(2010) A. N. Sferruzzi-Perri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Altered levels of insulin-like growth factor binding protein proteases in preeclampsia and intrauterine growth restriction

(2010) Julian K. Christians et al.   PRENATAL DIAGNOSIS

Adam12 plays a role during uterine decidualization in mice

(2009) Li Zhang et al.   CELL AND TISSUE RESEARCH

Critical growth factors and signalling pathways controlling human trophoblast invasion

(2009) Martin Knfler   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Placental Origins of Preeclampsia

(2008) Berthold Huppertz   HYPERTENSION

Cellular roles of ADAM12 in health and disease

(2008) Marie Kveiborg et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY