Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction

(2020) Xue-Jun Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

(2019) Kah Yong Goh et al.   Redox Biology

Mitophagy Reduces Oxidative Stress Via Keap1 (Kelch-Like Epichlorohydrin-Associated Protein 1)/Nrf2 (Nuclear Factor-E2-Related Factor 2)/PHB2 (Prohibitin 2) Pathway After Subarachnoid Hemorrhage in Rats

(2019) Tongyu Zhang et al.   STROKE

MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway

(2019) Jie Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

(2019) Tongyu Zhang et al.   EXPERIMENTAL NEUROLOGY

Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells

(2019) Dandan Han et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of pyrroloquinoline quinone against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway

(2019) Ziqiang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes

(2019) Armand Jaminon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress contributes to vascular calcification in patients with chronic kidney disease

(2019) Mei Huang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function

(2018) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

(2018) Rachel A. Gioscia-Ryan et al.   JOURNAL OF APPLIED PHYSIOLOGY

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Vascular calcification in chronic kidney disease: different bricks in the wall?

(2017) Marc Vervloet et al.   KIDNEY INTERNATIONAL

Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI

(2017) Xiaoge Liu et al.   MAGNETIC RESONANCE IN MEDICINE

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission

(2017) Lei Cui et al.   VASCULAR PHARMACOLOGY

Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats

(2017) Xue-ying Chang et al.   Biomed Research International

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

(2016) Xiangling Yin et al.   HUMAN MOLECULAR GENETICS

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

(2015) Anna J. Dare et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Mitochondria: a new therapeutic target in chronic kidney disease

(2015) Simona Granata et al.   Nutrition & Metabolism

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

(2014) Rachel A. Gioscia-Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

The antioxidant tempol ameliorates arterial medial calcification in uremic rats: Important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease

(2011) Shunsuke Yamada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway

(2011) Hyunsoo Kim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

(2008) Meredith F. Ross et al.   BIOCHEMICAL JOURNAL

Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

(2008) Rukshana C. Shroff et al.   CIRCULATION