Review
Nutrition & Dietetics
Carolyn Ledowsky, Abela Mahimbo, Vanessa Scarf, Amie Steel
Summary: Women of childbearing age and pregnant women in high-income countries do not get sufficient folate intake from food sources alone and need to take folic acid supplements. However, most women taking folic acid supplements exceed the upper tolerable limit. Therefore, the recommendations and upper tolerable limit for folic acid supplements need to be reevaluated.
Letter
Medicine, General & Internal
Steven Woloshin, Barnett S. Kramer
Summary: This article discusses the role and limitations of graphs, as well as how to avoid being misled by them. It also mentions a recent journal article that featured a graph considered to be misleading.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Khadijah Alnabbat, Ali M. Fardous, Aiman Shahab, Andrew A. James, Manhel R. Bahry, Ahmad R. Heydari
Summary: This study found that high consumption of folic acid from fortified foods can lead to genomic instability in peripheral lymphocytes, which is consistent with previous reports.
Article
Nutrition & Dietetics
Cecilia Zanin Palchetti, Josiane Steluti, Eliseu Verly-Jr, Eduardo De Carli, Rosely Sichieri, Edna Massae Yokoo, Rosangela Alves Pereira, Dirce Maria Lobo Marchioni
Summary: The study compared the evolution of dietary folate intake in the Brazilian population in two post-fortification periods, estimating the prevalence of folate inadequacy (POFI) and the contribution of food groups to folate intake. Despite mandatory folic acid flour fortification in Brazil for nearly two decades, an increase in POFI was observed in 2017-2018. This study provides important scientific information to guide public health fortification strategies.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Fenglei Wang, Kana Wu, Yanping Li, Rui Song, You Wu, Xuehong Zhang, Mingyang Song, Liming Liang, Stephanie A. Smith-Warner, Edward L. Giovannucci, Walter C. Willett
Summary: The study aimed to examine the association between folate intake in different chemical forms and colorectal cancer risk, especially in the postfortification era in the United States. The results showed that both total folate intake and synthetic folic acid intake were associated with a lower risk of colorectal cancer after long latency periods. High folate intake in the postfortification period was not related to increased colorectal cancer risk in the US female population.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Marisa A. Patti, Joseph M. Braun, Tye E. Arbuckle, Amanda J. MacFarlane
Summary: Maintaining optimal folate levels during early gestation helps reduce the risk of neural tube defects. While inadequate folate intake remains a concern, consuming higher than recommended doses of folic acid does not offer much additional benefit. In the context of mandatory fortification, factors such as socioeconomic status, maternal age, parity, and pre-pregnancy BMI are associated with adequate folate intake and reduced risk of neural tube defects.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Food Science & Technology
Shrooq Ismail, Sereen Eljazzar, Vijay Ganji
Summary: Inadequate folate intake during pregnancy is the leading cause of neural tube defects (NTDs) in newborns. The mandatory fortification of folic acid in processed cereals in the US has decreased the prevalence of NTDs and also had unintended benefits such as reducing anemia and the risk of cardiovascular diseases. However, there are potential issues with folic acid fortification that need to be monitored, such as the presence of unmetabolized folic acid and increased risk of cancer.
Article
Multidisciplinary Sciences
Anteneh Berhane, Tefera Belachew
Summary: This study aims to estimate the trend and burden of neural tube defects in Eastern Ethiopia and investigate the epidemiological implications of the findings. The study found an increasing trend and burden of neural tube defects, with insignificant importance of preconception folic acid supplementation in the region. Therefore, it is recommended to consider preconception folic acid supplementation in conjunction with healthcare services to reduce the risk of neural tube defects in the region.
Article
Education, Special
J. Jory
Summary: This study retrospectively reviewed the folate status of Canadian children and infants with Down Syndrome, and found that their red blood cell folate levels were higher than the general Canadian population and US children with Down Syndrome. This suggests that maternal folic acid supplementation and fortified foods may have important implications for Down Syndrome.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2022)
Article
Nutrition & Dietetics
Igor Pravst, Ziva Lavrisa, Masa Hribar, Hristo Hristov, Naska Kvarantan, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Katja Zmitek, Anita Kusar
Summary: Folate deficiency is common in Slovenia, with low folate intake observed in various age groups. Public health strategies are needed to promote the consumption of folate-rich foods and supplementation with folic acid may be necessary in specific vulnerable populations.
Article
Nutrition & Dietetics
Malia S. Q. Murphy, Katherine A. Muldoon, Hauna Sheyholislami, Nathalie Behan, Yvonne Lamers, Natalie Rybak, Ruth Rennicks White, Alysha L. J. Harvey, Laura M. Gaudet, Graeme N. Smith, Mark C. Walker, Shi Wu Wen, Amanda J. MacFarlane
Summary: The study found that high-dose folic acid supplementation in early pregnancy can increase maternal serum folate concentrations but does not increase red blood cell folate concentrations, suggesting tissue saturation. Higher UMFA concentrations in women receiving high-dose folic acid supplements suggest that these doses may be supraphysiological, but there is no evidence of altered 1-carbon metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Immunology
Jeffry S. Tang, Alissa Cait, Reuben M. White, Homayon J. Arabshahi, David O'Sullivan, Olivier Gasser
Summary: Fortification with folic acid is widely mandated for preventing neural tube defects, but excessive intake of folic acid may lead to adverse health effects. This study hypothesizes that the inconsistent detection and elusive etiology of these effects are related to the in vivo generation of an immunosuppressive folic acid metabolite. The researchers predict that substituting folic acid with a bioequivalent folate vitamer can eliminate these adverse health outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Omer F. Celik, Daniel J. O'Sullivan
Summary: Five different bifidobacterial cultures were tested for their de novo folate production ability based on their folate biosynthetic gene content. A new medium (YNB+) was developed as the previous folate-free media could not support their growth. The presence of certain genes or the absence of others in the genome annotations cannot accurately predict their folate dependency.
Article
Nutrition & Dietetics
Josiane Steluti, Andreia Machado Miranda, Eduardo De Carli, Cecilia Zanin Palchetti, Regina Mara Fisberg, Dirce Maria Lobo Marchioni
Summary: A study in São Paulo City, Brazil, investigated the association between inflammatory markers and unmetabolized folic acid (UMFA) in a population exposed to mandatory fortification. The results showed that higher UMFA concentrations were linked to lower levels of proinflammatory markers like TNF-alpha, IL-1 beta, and IL-12. This suggests a connection between folate metabolism and inflammatory status in adults.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Yulia Shulpekova, Vladimir Nechaev, Svetlana Kardasheva, Alla Sedova, Anastasia Kurbatova, Elena Bueverova, Arthur Kopylov, Kristina Malsagova, Jabulani Clement Dlamini, Vladimir Ivashkin
Summary: Folates, with a pterine core structure, play essential roles as coenzymes in one-carbon pathways and are found in various organisms. Deficiencies in folates can lead to severe health issues, while excessive intake may have negative effects on embryonic development and pre-cancerous cell growth.
Review
Food Science & Technology
Rhowell Jr. N. Tiozon, Kristel June D. Sartagoda, Alisdair R. Fernie, Nese Sreenivasulu
Summary: Pigmented rice has gained attention for its nutritional value and biological activities, and post-harvest processes and product development methods can help retain phytochemicals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biotechnology & Applied Microbiology
Saurabh Badoni, Sabiha Parween, Robert J. Henry, Nese Sreenivasulu
Summary: This review summarizes the use of systems biology tools in studying rice seed development and the accumulation of storage products. Key genes identified through a holistic approach have the potential to modify the biochemical composition and improve the quality and nutritional value of rice grains. Additionally, studies of other model systems are considered due to the limited information on the rice transcriptome.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Singh Shreya, Deepak Kasote, Debadatta Mohapatra, Gaurav Gopal Naik, Santosh Kumar Guru, Nese Sreenivasulu, Yashpal Sharma, Alakh N. Sahu
Summary: In this paper, a preliminary study was conducted on Pleurotus osteratus, a preferred mushroom rich in nutrients and myco-bioactive molecules. The extract of P. osteratus was screened against human cancer cell lines and the hexane (H) fraction showed the highest cytotoxicity. Polyphenol and ergosterol were identified as potential biomarkers responsible for the cytotoxic potential of P. osteratus. Myco-metabolite profiling of different fractions of P. osteratus was carried out, and the identified myco-metabolites showed a probable synergistic action contributing to the observed cytotoxicity potential of the H fraction.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Hameeda Itagi, Kristel June D. Sartagoda, Vipin Pratap, Priyabrata Roy, Rhowell N. Tiozon, Ahmed Regina, Nese Sreenivasulu
Summary: Iron-pan roasting is a common processing technique used in India to produce value-added popped rice. This study examined the effects of the popping process on physical and biochemical properties of traditional landrace genotypes black rice, red rice, Kalanamak, and a high-yielding variety Samba Mahsuri. The results showed that popping increased volume and popping percentage in Samba Mahsuri, while also increasing the Fe content in all genotypes. Popped rice retained bioactives, antioxidant potency, and total dietary fiber, indicating its potential as a nutraceutically-rich and wholesome ready-to-eat product.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Erstelle A. Pasion, Gopal Misra, Ajay Kohli, Nese Sreenivasulu
Summary: A comprehensive study was conducted to explore the genetic architecture of the brown rice ionome, revealing candidate genes and molecular mechanisms underlying micronutrient signatures. Functional pathways were identified using gene regulatory networks, providing important insights on ionome variations in rice and the genome-ionome relationships.
Article
Plant Sciences
Rhowell Jr. N. Tiozon, Joerg Fettke, Nese Sreenivasulu, Alisdair R. Fernie
Summary: In the last decade, research on resistant starch has gained attention for its potential in preventing and inhibiting chronic diseases like diabetes, cancer, and obesity. Increasing the amylose content and resistant starch in rice has been crucial for improving its nutritional value. However, the mechanism of resistant starch formation is complex due to various genetic factors. This review discusses the regulatory factors influencing resistant starch formation and highlights the developments in rice compared to other cereals. Furthermore, it explores the potential applications of high resistant starch mutants in various industries and proposes the use of this information for marker-assisted breeding and genome editing to enhance rice varieties with higher resistant starch content.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Article
Food Science & Technology
Hameeda Banu Itagi, Kristel June D. Sartagoda, Nitesh Gupta, Vipin Pratap, Priyabrata Roy, Rhowell N. Tiozon Jr, Ahmed Regina, Nese Sreenivasulu
Summary: This study investigated the potential of two traditional Indian rice landraces, Kalanamak and Chak-hao, as alternative cereals for producing whole grain gluten-free cookies with enriched bioactive compounds. The study found that substituting refined wheat flour with whole grain rice flours significantly affected the properties of the cookies, resulting in cookies that were crispier and had higher sensory evaluation scores. These whole grain rice flour cookies also contained higher levels of bioactive compounds and nutraceutical benefits.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Edwige Gaby Nkouaya Mbanjo, Erstelle A. Pasion, Huw Jones, Socorro Carandang, Gopal Misra, John Carlos Ignacio, Tobias Kretzschmar, Nese Sreenivasulu, Lesley Ann Boyd
Summary: This study investigated the genetic relationship between pericarp color and phenolic compounds in rice. A genome-wide association study identified over 280 single nucleotide polymorphisms (SNPs) associated with nutritional and color-related traits. Targeted association analysis revealed 52 candidate genes associated with 24 traits, suggesting the important role of these genes in the regulation of phenolic compounds and pericarp color in rice.
Review
Plant Sciences
M. Iqbal R. Khan, Faroza Nazir, Chirag Maheshwari, Priyanka Chopra, Himanshu Chhillar, Nese Sreenivasulu
Summary: Plant nutrition is crucial for sustainable agriculture and human health. This review focuses on the adjustment of nutrient pools and the enrichment of minerals in edible sources to ensure plant growth under stressful conditions and address future nutritional security. It also discusses breeding and biotechnological strategies to optimize nutrient acquisition and distribution in plants, as well as recent advancements in biofortification approaches for crop plants to enhance yield and grain mineral concentrations under different environments.
Editorial Material
Plant Sciences
Deepak Kasote, Jisun Lee, Nese Sreenivasulu
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Agriculture, Multidisciplinary
P. B. Kavi Kishor, Rajasheker Guddimalli, Jayant Kulkarni, Prashant Singam, Anil Kumar Somanaboina, Tejaswi Nandimandalam, Swaroopa Patil, Rathnagiri Polavarapu, Prashanth Suravajhala, Nese Sreenivasulu, Suprasanna Penna
Summary: Due to global climate change, increasing acute water deficit, soil salinity, and high temperature negatively affect plant growth and development. However, moderate abiotic stresses can have beneficial effects on the postharvest storage characters of fruits, leading to increased antioxidant activity and health benefits. The quality of fruits depends on trade-offs between productivity, plant defense, and the frequency, duration, and intensity of stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
