Food additives containing nanoparticles induce gastrotoxicity, hepatotoxicity and alterations in animal behavior: The unknown role of oxidative stress

Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: A multitarget approach

(2020) Roberta Tassinari et al.   FOOD AND CHEMICAL TOXICOLOGY

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

(2020) Mingxi Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silicon dioxide and titanium dioxide particles found in human tissues

(2020) Ruud J. B. Peters et al.   Nanotoxicology

In vitro and in situ experiments to evaluate the biodistribution and cellular toxicity of ultrasmall iron oxide nanoparticles potentially used as oral iron supplements

(2020) Jenifer Garcia-Fernandez et al.   Nanotoxicology

Genotoxicity of Silver Nanoparticles

(2020) Adriana Rodriguez-Garraus et al.   Nanomaterials

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

(2020) Sergio Quesada-Vázquez et al.   Cells

Titanium dioxide nanoparticles via oral exposure leads to adverse disturbance of gut microecology and locomotor activity in adult mice

(2020) Shanshan Zhang et al.   ARCHIVES OF TOXICOLOGY

Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models

(2020) Raphaël Cornu et al.   ARCHIVES OF TOXICOLOGY

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

(2020) May Bin-Jumah et al.   International Journal of Nanomedicine

The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity

(2020) Andrés García-Sánchez et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet

(2020) Catherine Meza-Torres et al.   Antioxidants

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

(2020) Boushra Dalile et al.   NEUROPSYCHOPHARMACOLOGY

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

(2020) Bruno Lamas et al.   Particle and Fibre Toxicology

Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

(2020) Christine Coméra et al.   Particle and Fibre Toxicology

Soluble silver ions from silver nanoparticles induce a polarised secretion of interleukin-8 in differentiated Caco-2 cells

(2020) Madeleine Polet et al.   TOXICOLOGY LETTERS

Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model

(2020) Ghassan M. Sulaiman et al.   Scientific Reports

Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder

(2019) Kenny L. Chan et al.   PHYSIOLOGY

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

(2019) Ewa Baranowska-Wójcik et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress

(2019) Oluyomi Stephen Adeyemi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status

(2019) Laura Talamini et al.   Nanotoxicology

Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring

(2019) Zachary A. Cordner et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)

(2019) Gurunathan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative analysis of honey and citrate stabilized gold nanoparticles: In vitro interaction with proteins and toxicity studies

(2019) Adina Boldeiu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Titanium Dioxide Nanoparticles Elicit Lower Direct Inhibitory Effect on Human Gut Microbiota Than Silver Nanoparticles

(2019) Richard T Agans et al.   TOXICOLOGICAL SCIENCES

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2)

(2019) Lance K. Blevins et al.   FOOD AND CHEMICAL TOXICOLOGY

Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level

(2019) Shingo Nakajima et al.   INTERNATIONAL JOURNAL OF OBESITY

Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

(2019) Hailong Hu et al.   Particle and Fibre Toxicology

Estimation of the Uncertainties Related to the Measurement of the Size and Quantities of Individual Silver Nanoparticles in Confectionery

(2019) Nadia Waegeneers et al.   Materials

Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats

(2019) Usha Singh Gaharwar et al.   International Journal of Nanomedicine

Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles

(2019) Zhangjian Chen et al.   Particle and Fibre Toxicology

Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles

(2019) Héloïse Proquin et al.   Scientific Reports

Comparative study of nano and bulk Fe3O4 induced oxidative stress in Wistar rats

(2018) Utkarsh A. Reddy et al.   BIOMARKERS

Biosynthesis of AgNPs by B. maydis and its antifungal effect against Exserohilum turcicum

(2018) Weidong Huang et al.   IET Nanobiotechnology

In vivo investigation on the chronic hepatotoxicity induced by intraperitoneal administration of 10-nm silicon dioxide nanoparticles

(2018) Mansour Almansour et al.   International Journal of Nanomedicine

In vivo bio-distribution, clearance and toxicity assessment of biogenic silver and gold nanoparticles synthesized from Abutilon indicum in Wistar rats

(2018) Rani Mata et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Evaluation of the uptake, storage and cell effects of nano-iron in enterocyte-like cell models

(2018) Daniel Turiel-Fernández et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Detection of titanium particles in human liver and spleen and possible health implications

(2018) M. B. Heringa et al.   Particle and Fibre Toxicology

Feraheme® suppresses immune function of human T lymphocytes through mitochondrial damage and mitoROS production

(2018) Ankit Shah et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silver ions are responsible for memory impairment induced by oral administration of silver nanoparticles

(2018) M. Węsierska et al.   TOXICOLOGY LETTERS

Consumption of ultra-processed foods and associated sociodemographic factors in the USA between 2007 and 2012: evidence from a nationally representative cross-sectional study

(2018) Larissa Galastri Baraldi et al.   BMJ Open

Food-grade TiO2 is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection

(2018) Pauline Talbot et al.   JOURNAL OF NANOBIOTECHNOLOGY

Cytotoxic Potential and Molecular Pathway Analysis of Silver Nanoparticles in Human Colon Cancer Cells HCT116

(2018) Sangiliyandi Gurunathan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Titanium Dioxide in Food Products: Quantitative Analysis Using ICP-MS and Raman Spectroscopy

(2018) Jin-Hee Lim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells

(2018) Marie Dorier et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Orally administered gold nanoparticles protect against colitis by attenuating Toll-like receptor 4- and reactive oxygen/nitrogen species-mediated inflammatory responses but could induce gut dysbiosis in mice

(2018) Suqin Zhu et al.   JOURNAL OF NANOBIOTECHNOLOGY

Effects of silver nanoparticles on the interactions of neuron- and glia-like cells: Toxicity, uptake mechanisms, and lysosomal tracking

(2017) I-Lun Hsiao et al.   ENVIRONMENTAL TOXICOLOGY

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

(2017) Jae Woong Han et al.   International Journal of Nanomedicine

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

(2017) Yu-Guo Yuan et al.   International Journal of Nanomedicine

Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat

(2017) Thomas P. Farrell et al.   JOURNAL OF FOOD SCIENCE

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model

(2016) Ismael M. Urrutia-Ortega et al.   FOOD AND CHEMICAL TOXICOLOGY

Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD

(2016) Thomas Lee et al.   GUT

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

(2016) Owein Guillemot-Legris et al.   Journal of Neuroinflammation

Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver

(2016) Kazue Honma et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

(2016) Héloïse Proquin et al.   MUTAGENESIS

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of Nanoscale Ingredients in Commercial Food Products and their Induction of Mitochondrially Mediated Cytotoxic Effects on Human Mesenchymal Stem Cells

(2015) Jegan Athinarayanan et al.   JOURNAL OF FOOD SCIENCE

Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

(2015) Laetitia C. Pele et al.   Particle and Fibre Toxicology

Dietary silver nanoparticles can disturb the gut microbiota in mice

(2015) Sybille van den Brule et al.   Particle and Fibre Toxicology

Cytotoxic effects of cytoplasmic-targeted and nuclear-targeted gold and silver nanoparticles in HSC-3 cells – A mechanistic study

(2015) Lauren A. Austin et al.   TOXICOLOGY IN VITRO

Toxicity and Biokinetics of Colloidal Gold Nanoparticles

(2015) Mi-Rae Jo et al.   Nanomaterials

Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation

(2014) James J. Faust et al.   CELL BIOLOGY AND TOXICOLOGY

Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells

(2014) Jegan Athinarayanan et al.   CELL BIOLOGY AND TOXICOLOGY

Fructose supplementation worsens the deleterious effects of short-term high-fat feeding on hepatic steatosis and lipid metabolism in adult rats

(2014) Raffaella Crescenzo et al.   EXPERIMENTAL PHYSIOLOGY

Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles

(2014) Sebastiano Di Bucchianico et al.   International Journal of Nanomedicine

Mechanisms of TiO2nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons

(2014) Lei Sheng et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The blood-brain barrier: Structure, function and therapeutic approaches to cross it

(2014) Marta Tajes et al.   MOLECULAR MEMBRANE BIOLOGY

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

(2014) Katherine Williams et al.   Nanotoxicology

Sub-chronic toxicity study in rats orally exposed to nanostructured silica

(2014) Meike van der Zande et al.   Particle and Fibre Toxicology

TiO2 Nanoparticles Induced Hippocampal Neuroinflammation in Mice

(2014) Yuguan Ze et al.   PLoS One

Oxidative stress following exposure to silver and gold nanoparticles in mice

(2014) Rupal Shrivastava et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

The Role of the Hippocampus in Avoidance Learning and Anxiety Vulnerability

(2014) Tara P. Cominski et al.   Frontiers in Behavioral Neuroscience

Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells

(2013) Diego Mateo et al.   TOXICOLOGY MECHANISMS AND METHODS

Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure

(2012) Meike van der Zande et al.   ACS Nano

Presence of Nano-Sized Silica during In Vitro Digestion of Foods Containing Silica as a Food Additive

(2012) Ruud Peters et al.   ACS Nano

Biochemical alterations induced by acute oral doses of iron oxide nanoparticles in Wistar rats

(2012) Monika Kumari et al.   DRUG AND CHEMICAL TOXICOLOGY

Titanium Dioxide Nanoparticles in Food and Personal Care Products

(2012) Alex Weir et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Toxicity of nanomaterials

(2011) Shahriar Sharifi et al.   CHEMICAL SOCIETY REVIEWS

Methods for the determination of European Union-permitted added natural colours in foods: a review

(2011) M.J. Scotter   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles

(2011) Renping Hu et al.   JOURNAL OF HAZARDOUS MATERIALS

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells

(2011) Fen Wang et al.   TOXICOLOGY IN VITRO

Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

(2010) Renping Hu et al.   BIOMATERIALS

Autophagy and oxidative stress associated with gold nanoparticles

(2010) Jasmine J. Li et al.   BIOMATERIALS

Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells

(2010) William J. Trickler et al.   TOXICOLOGICAL SCIENCES

Spectrophotometric Trace Determination of Iron in Food, Milk, and Tea Samples using a New Bis-azo Dye as Analytical Reagent

(2008) Ashok K. Sharma et al.   Food Analytical Methods