A Multihit Model

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease

(2014) P.J. Basso et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

IL-10 and Macrophages Orchestrate Gut Homeostasis

(2014) Alberto Mantovani et al.   IMMUNITY

Induction of Bacterial Antigen-Specific Colitis by a Simplified Human Microbiota Consortium in Gnotobiotic Interleukin-10-/- Mice

(2014) C. S. Eun et al.   INFECTION AND IMMUNITY

Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice

(2014) Marijana Basic et al.   INFLAMMATORY BOWEL DISEASES

Innate PI3K p110  Regulates Th1/Th17 Development and Microbiota-Dependent Colitis

(2014) E. C. Steinbach et al.   JOURNAL OF IMMUNOLOGY

Infectious etiopathogenesis of Crohn’s disease

(2014) Jessica Carrière   WORLD JOURNAL OF GASTROENTEROLOGY

The secret garden's gardeners

(2013) Philip Hunter   EMBO REPORTS

Geographical variability and environmental risk factors in inflammatory bowel disease

(2013) Siew C Ng et al.   GUT

Mapping colitis susceptibility in mouse models: distal chromosome 3 contains major loci related to Cdcs1

(2013) Manuela Buettner et al.   PHYSIOLOGICAL GENOMICS

Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis

(2013) Ines Yang et al.   PLoS One

The effects of intestinal microbial community structure on disease manifestation in IL-10-/- mice infected with Helicobacter hepaticus

(2013) Nabeetha A Nagalingam et al.   Microbiome

Time to include the gut microbiota in the hygienic standardisation of laboratory rodents

(2012) André Bleich et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Maintenance of small intestinal and colonic tolerance by IL-10-producing regulatory T cell subsets

(2012) Sharon Veenbergen et al.   CURRENT OPINION IN IMMUNOLOGY

Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions

(2012) Gwen Büchler et al.   INFLAMMATORY BOWEL DISEASES

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

(2011) Alan W Walker et al.   BMC MICROBIOLOGY

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

(2011) Seth M. Bloom et al.   Cell Host & Microbe

Inflamed gut mucosa: downstream of interleukin-10

(2011) Gregor Paul et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10tm1Cgn (IL-10−/−) mice

(2011) Mark T. Whary et al.   IMMUNOLOGY

Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis

(2011) Micha Hoffmann et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus

(2011) J. Ermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, diagnosis, and management

(2010) Signe Larsen et al.   ANNALS OF MEDICINE

Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species

(2010) Matthew PG Barnett et al.   BMC IMMUNOLOGY

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Colitis and Intestinal Inflammation in IL10−/− Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity

(2010) Mark S. Wilson et al.   GASTROENTEROLOGY

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease

(2010) G Jurisic et al.   GENES AND IMMUNITY

Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-101

(2010) Marina C. Pils et al.   INFLAMMATORY BOWEL DISEASES

Highlighting new phylogenetic specificities of Crohnʼs disease microbiota

(2010) S. Mondot et al.   INFLAMMATORY BOWEL DISEASES

Diversity of caecal bacteria is altered in interleukin-10 gene-deficient mice before and after colitis onset and when fed polyunsaturated fatty acids

(2010) B. Knoch et al.   MICROBIOLOGY-SGM

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice

(2009) Maike F. de Buhr et al.   INFLAMMATORY BOWEL DISEASES

Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity

(2009) Andre Bleich et al.   INFLAMMATORY BOWEL DISEASES

Gastrointestinal Norovirus Infection Associated With Exacerbation of Inflammatory Bowel Disease

(2009) Raheel R Khan et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction

(2008) Andre Bleich et al.   GASTROENTEROLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE