Article
Immunology
Eva M. Medina -Rodriguez, Kenner C. Rice, Richard S. Jope, Eleonore Beurel
Summary: This study found that chronic restraint stress induces depressive-like behaviors in mice, with both males and females showing similar behavioral changes. However, there are differences in the inflammatory response, changes in microglia, and Toll-like receptor 4 expression between male and female mice. Treatment with a Toll-like receptor 4 antagonist shows more effective anti-depressant-like effects in male mice than in females, and this effect is not mediated by the microbiome. These findings suggest the need to consider different mechanisms in potential sex-specific treatments for depression.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Microbiology
Francesco Valeri, Malena dos Santos Guilherme, Fuqian He, Nicolai M. Stoye, Andreas Schwiertz, Kristina Endres
Summary: This study investigated how cecal material from older donors may affect early pathological changes of Alzheimer's disease. While behavioral deficits were not worsened, individual brain regions (prefrontal cortex and dentate gyrus) showed increased plaque load after transfer of material from older animals.
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Microbiology
Tracey Bear, Nicole Roy, Julie Dalziel, Chrissie Butts, Jane Coad, Wayne Young, Shanthi G. Parkar, Duncan Hedderley, Hannah Dinnan, Sheridan Martell, Susanne Middlemiss-Kraak, Pramod Gopal
Summary: The relationship between microbiota profile and stress exposure is still unclear. A rat model of unpredictable chronic mild stress (UCMS) was used to investigate this relationship. Female Sprague Dawley rats showed atypical behaviors following UCMS, but no depressive-like behaviors were observed. The relative abundance of taxa from the Clostridiales order and Desulfovibrionaceae family correlated with anxiety-like behaviors and plasma cytokine concentrations, suggesting the brain-to-gut influence of mild anxiety with a microbiota profile that may involve inflammatory pathways.
Article
Nutrition & Dietetics
Daphne M. Rodriguez, Korry J. Hintze, Giovanni Rompato, Eliza C. Stewart, Abbey H. Barton, Emily Mortensen-Curtis, Porter A. Green, Arnaud J. Van Wettere, Aaron J. Thomas, Abby D. Benninghoff
Summary: Fecal microbiota transfer from mice fed either a healthy or Western diet did not significantly affect colitis symptoms or colon tumorigenesis in recipient mice, indicating that the gut microbiome may not directly contribute to disease development in this model.
Article
Endocrinology & Metabolism
Kalpana D. Acharya, Randall H. Friedline, Doyle V. Ward, Madeline E. Graham, Lauren Tauer, Doris Zheng, Xiaodi Hu, Willem M. de Vos, Beth A. McCormick, Jason K. Kim, Marc J. Tetel
Summary: Estrogens have a protective effect against weight gain and metabolic disruption in women and female rodents, which is associated with modifications in gut microbiota. However, transplanting gut microbiota from estrogen-treated lean mice, with or without Akkermansia muciniphila, did not prevent high fat diet-induced body weight gain, fat mass gain, and hyperglycemia in estrogen-deficient recipients. In fact, supplementation of A. muciniphila worsened metabolic health in estrogen-deficient female rodents with a high fat diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jennifer L. MacNicol, Simone Renwick, Caroline M. Ganobis, Emma Allen-Vercoe, Jeffery Scott Weese, Wendy Pearson
Summary: This study evaluated three fermentation systems to replicate the equine cecal environment and found that the fecal sample is not representative of the cecal system, while the cecal inoculum maintained in either a chemostat batch fermenter or anaerobic chamber is fairly comparable. The metabolite concentrations, but not rate of production, were significantly different between the two cecal systems.
Article
Biochemistry & Molecular Biology
Ananta Prasad Arukha, Christian Furlan Freguia, Meerambika Mishra, Jyoti K. Jha, Subhashinie Kariyawasam, Neil A. Fanger, Ellen M. Zimmermann, Gary R. Fanger, Bikash Sahay
Summary: Inflammatory bowel disease (IBD) is a gastrointestinal inflammation disease comprising Crohn's disease and ulcerative colitis, with multifactorial etiology and treatments focusing on reducing inflammatory signals. Studies have shown that a surface layer protein A (SlpA) of certain probiotics possesses anti-inflammatory properties to alleviate colitis in mice.
Article
Immunology
Xuemin Jin, Xue Bai, Ying Zhao, Zijian Dong, Jianda Pang, Mingyuan Liu, Xiaolei Liu
Summary: This study revealed that Nrf2 is essential for M2 polarization induced by T. spiralis ES to alleviate colitis in mice. Adoptive transfer of ES-treated M2 decreased IFN-gamma levels and increased IL-4 and IL-10 levels in vivo, while ES-treated Nrf2 KO macrophages showed impaired ability to treat colitis with deficient elevation of IL-4 and IL-10 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Amal Aburahma, Emma L. Stewart, Srishti Rana, Ray Larsen, Christopher S. Ward, Jon E. Sprague
Summary: This study investigated the effects of bidirectional fecal microbial transplant (FMT) between male and female rats on methamphetamine (MA)-induced hyperthermia. MA treatment resulted in higher core body temperatures in male groups compared to females. Plasma concentrations of MA and amphetamine were higher in females than males. The microbiome of male and female rats showed differences in the relative abundance of Firmicutes and Bacteroidetes. However, these differences do not seem to contribute to the sex-based differences in MA-induced hyperthermia.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Environmental Sciences
Lilong Jiang, Yanjun Hong, Pingting Xiao, Xiaoxiao Wang, Jinghui Zhang, Ehu Liu, Huijun Li, Zongwei Cai
Summary: This study demonstrated the critical role of the fecal microbiota in PFOS-induced liver injury in mice and identified several critical bacteria that could protect against liver injury induced by PFOS in male and female mice.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Immunology
Megan T. Zangara, Andras K. Ponti, Noah D. Miller, Morgan J. Engelhart, Philip P. Ahern, Naseer Sangwan, Christine McDonald
Summary: Food additives, such as maltodextrin (MDX), have been found to contribute to the pathogenesis of inflammatory bowel disease by disrupting the balance of epithelial cell differentiation and proliferation. This study investigated the mechanisms by which MDX alters the development of colitis in a murine model, and found that MDX consumption increased the incidence and severity of colitis, disrupted microbiome composition, and decreased mucus production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Article
Nutrition & Dietetics
Dulce M. Minaya, Noah L. Weinstein, Krzysztof Czaja
Summary: This study successfully implemented cecal fistula implantation using 3D printing technology, providing an effective method for long-term and minimally invasive access to the gut microbiome. The fistula implantation had no significant impact on food intake, body weight, fat mass, or microglia activation, but temporarily reduced gut microbial diversity.
Article
Pharmacology & Pharmacy
Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, Tong Liu
Summary: This study found that ganciclovir can improve DSS-induced ulcerative colitis by inhibiting the STING signaling pathway. The therapeutic effect of this drug on UC in mice is promising.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Microbiology
Patrick D. Schloss, Melissa Junior, Rebecca Alvania, Cesar A. Arias, Andreas Baumler, Arturo Casadevall, Corrella Detweiler, Harold Drake, Jack Gilbert, Michael J. Imperiale, Susan Lovett, Stanley Maloy, Alexander J. McAdam, Irene L. G. Newton, Michael J. Sadowsky, Rozanne M. Sandri-Goldin, Thomas J. Silhavy, Peter Tontonoz, Jo-Anne H. Young, Craig E. Cameron, Isaac Cann, A. Oveta Fuller, Ariangela J. Kozik
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Editorial Material
Microbiology
Patrick D. Schloss, Melissa Junior, Rebecca Alvania, Cesar A. Arias, Andreas Baumler, Arturo Casadevall, Corrella Detweiler, Harold Drake, Jack Gilbert, Michael J. Imperiale, Susan Lovett, Stanley Maloy, Alexander J. McAdam, Irene L. G. Newton, Michael J. Sadowsky, Rozanne M. Sandri-Goldin, Thomas J. Silhavy, Peter Tontonoz, Jo-Anne H. Young, Craig E. Cameron, Isaac Cann, A. Oveta Fuller, Ariangela J. Kozik
Article
Biochemical Research Methods
Ada K. Hagan, Nicholas A. Lesniak, Marcy J. Balunas, Lucas Bishop, William L. Close, Matthew D. Doherty, Amanda G. Elmore, Kaitlin J. Flynn, Geoffrey D. Hannigan, Charlie C. Koumpouras, Matthew L. Jenior, Ariangela J. Kozik, Kathryn McBride, Samara B. Rifkin, Joshua M. A. Stough, Kelly L. Sovacool, Marc A. Sze, Sarah Tomkovich, Begum D. Topcuoglu, Patrick D. Schloss
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kilia Y. Liu, Cindy H. Nakatsu, Yava Jones-Hall, Ariangela Kozik, Qing Jiang
Summary: The study demonstrates that alpha-tocopherol and gamma-tocopherol-rich tocopherols can alleviate symptoms of colitis induced by DSS, protect intestinal barrier function, and have a positive impact on gut microbiota. Gamma-tocopherol-rich tocopherols show significant effects in repairing barrier function and promoting the health of gut microbiota.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Editorial Material
Gastroenterology & Hepatology
Meng Pu, Janice M. Cho, Scott A. Cunningham, Gaurav K. Behera, Sarah Becker, Talal Amjad, Kerryl E. Greenwood-Quaintance, Helena Mendes-Soares, Yava Jones-Hall, Patricio R. Jeraldo, Jun Chen, Gary Dunny, Robin Patel, Purna C. Kashyap
Summary: The study identified a potential plasmid-mediated mechanism leading to decreased sensitivity of C difficile to vancomycin, which may contribute to treatment failure, and further experimental results supported this hypothesis.
Article
Biochemistry & Molecular Biology
Chao Yang, Yiying Zhao, Suji Im, Cindy Nakatsu, Yava Jones-Hall, Qing Jiang
Summary: The study revealed that vitamin E delta-tocotrienol and its metabolite delta TE-13' inhibited tumorigenesis, suppressed pro-inflammatory cytokines, and modulated gut microbiota in a murine colitis-associated colon cancer model. These findings suggest potential anticancer effects and gut microbiota-modulating properties of the metabolite.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Oncology
Ilektra Athanasiadi, Whitney D. Perez, Jeannie M. Plantenga, Yava Jones-Hall, Carlos J. Perez-Torres
Summary: The study introduced a half-brain mini-pig model of radiation-induced brain injury, demonstrating different responses to mild and severe doses, potentially serving as a valuable tool for investigating radiation-induced brain injury.
RADIATION ONCOLOGY
(2021)
Article
Mathematical & Computational Biology
Yixin Kong, Ariangela Kozik, Cindy H. Nakatsu, Yava L. Jones-Hall, Hyonho Chun
Summary: The study proposes a zero-inflated non-negative matrix factorization method for count data to address the phenomenon of excessive zeros, achieving improved accuracy and the smallest bias in simulations. The method is demonstrated to have superior performance in analyzing brain gene expression and fecal microbiome datasets.
INTERNATIONAL JOURNAL OF BIOSTATISTICS
(2022)
Editorial Material
Veterinary Sciences
Yava Jones-Hall
Summary: Establishing a digital pathology program at a new academic institution holds great promise, but also comes with its own set of challenges and pain points.
Article
Multidisciplinary Sciences
Brianyell McDaniel Mims, Josue Enriquez, Andrea Pires dos Santos, Yava Jones-Hall, Scot Dowd, Kathryn L. Furr, Matthew B. Grisham
Summary: Broad spectrum antibiotics treatment before and after adoptive transfer of allogeneic CD4(+) T cells exacerbated acute graft vs. host disease-induced bone marrow failure and spleen damage in lymphopenic NK cell-depleted mice, potentially due to reduction in beneficial anaerobic bacteria and expansion of pathogenic bacteria.
Article
Agriculture, Dairy & Animal Science
Katelyn M. Haydett, Steven T. Peper, Cynthia Reinoso Webb, Hannah S. Tiffin, Alexander N. Wilson-Fallon, Yava L. Jones-Hall, Stephen L. Webb, Steven M. Presley
Summary: The study assessed the potential role of wild pigs in transmitting Neospora caninum, highlighting the need for more reliable testing methods due to inconsistencies in results from different assays. Despite previous documentation of N. caninum seroprevalence in wild pigs, the study found variable results and emphasized the importance of standardized methodology for assessing disease prevalence in wildlife populations.
Article
Virology
Teodora Ivanciuc, Igor Patrikeev, Yue Qu, Massoud Motamedi, Yava Jones-Hall, Antonella Casola, Roberto P. Garofalo
Summary: Severe RSV infections in early life can lead to chronic airway disease. Nrf2 deficiency enhances disease severity and inflammatory response in RSV-infected mice, with increased viral replication and prolonged fibrosis observed.
Article
Biochemistry & Molecular Biology
Koedi S. Lawley, Raquel R. Rech, Aracely A. Perez Gomez, Laura Hopkins, Gang Han, Katia Amstalden, C. Jane Welsh, Colin R. Young, Yava Jones-Hall, David W. Threadgill, Candice L. Brinkmeyer-Langford
Summary: A study using CC mouse models found that genetic background plays a role in the clinical signs and neuropathological manifestations of TMEV infection. Different genetic backgrounds influence viral load and microglial/macrophage activation, leading to variable disease outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Allergy
Michelle El-Hosni, Ariangela Kozik, Molly Cook
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)