Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury

Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis

(2020) Tao Chen et al.   Cell Death & Disease

Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

(2020) Chunling Yuan et al.   NEUROCHEMICAL RESEARCH

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

(2019) Yuchun Zuo et al.   Journal of Neuroinflammation

Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma–Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice

(2018) Liang Wen et al.   JOURNAL OF NEUROTRAUMA

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

(2018) Junchi He et al.   NEUROBIOLOGY OF DISEASE

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

(2018) Yuguo Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E

(2017) Jianjun Zhong et al.   NEUROSCIENCE

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice

(2016) Fangfang Qi et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice

(2016) Hua-Sheng Zhang et al.   BRAIN RESEARCH

IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

(2016) Isaac Francos-Quijorna et al.   GLIA

Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury

(2016) Regina C. Armstrong et al.   NEUROPHARMACOLOGY

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

(2016) Xiangrong Liu et al.   STROKE

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders

(2015) Paul D. Drew et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Downregulation of STIM2 improves neuronal survival after traumatic brain injury by alleviating calcium overload and mitochondrial dysfunction

(2015) Wei Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neurorestoration after traumatic brain injury through angiotensin II receptor blockage

(2015) Sonia Villapol et al.   BRAIN

What’s New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment

(2015) Cesar Reis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frontal and frontoparietal injury differentially affect the ipsilateral corticospinal projection from the nonlesioned hemisphere in monkey (Macaca mulatta )

(2015) R.J. Morecraft et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer’s disease

(2015) Ana Knezovic et al.   JOURNAL OF NEURAL TRANSMISSION

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity

(2015) A. Mounier et al.   JOURNAL OF NEUROSCIENCE

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

(2015) N. Miyamoto et al.   JOURNAL OF NEUROSCIENCE

Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression

(2015) Thiruchelvam Kariharan et al.   NEUROBIOLOGY OF AGING

Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke

(2015) Michelangelo Certo et al.   PHARMACOLOGICAL RESEARCH

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia

(2015) Lijuan Han et al.   STROKE

Identification of Bexarotene as a PPARγAntagonist with HDX

(2015) David P. Marciano et al.   PPAR Research

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy

(2013) Nicolas T. Lindau et al.   BRAIN

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

A Review of Neuroprotection Pharmacology and Therapies in Patients with Acute Traumatic Brain Injury

(2012) Kevin W. McConeghy et al.   CNS DRUGS

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Candesartan, an Angiotensin II AT1-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice

(2012) Sonia Villapol et al.   NEUROPSYCHOPHARMACOLOGY

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Treatment of TBI with Collagen Scaffolds and Human Marrow Stromal Cells Increases the Expression of Tissue Plasminogen Activator

(2011) Asim Mahmood et al.   JOURNAL OF NEUROTRAUMA

Pioglitazone Reduces Secondary Brain Damage after Experimental Brain Trauma by PPAR-γ-Independent Mechanisms

(2011) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendrocyte vulnerability following traumatic brain injury in rats

(2011) George Lotocki et al.   NEUROSCIENCE LETTERS

Activated Microglia Inhibit Axonal Growth through RGMa

(2011) Mari Kitayama et al.   PLoS One

PPARγ-mediated advanced glycation end products regulate neural stem cell proliferation but not neural differentiation through the BDNF–CREB pathway

(2011) Shao-hua Wang et al.   TOXICOLOGY LETTERS

Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling

(2011) S Lee et al.   Cell Death & Disease

Sprouting of corticospinal tract axons from the contralateral hemisphere into the denervated side of the spinal cord is associated with functional recovery in adult rat after traumatic brain injury and erythropoietin treatment

(2010) Yanlu Zhang et al.   BRAIN RESEARCH

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

7-Ketocholesterol and cholesterol-5α,6α-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways

(2010) Po Lin Liao et al.   TOXICOLOGY LETTERS

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Erythropoietin Improves Histological and Functional Outcomes after Traumatic Brain Injury in Mice in the Absence of the Neural Erythropoietin Receptor

(2009) Ye Xiong et al.   JOURNAL OF NEUROTRAUMA

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE