Identification of Bexarotene as a PPARγAntagonist with HDX

Extending kinome coverage by analysis of kinase inhibitor broad profiling data

(2015) Edgar Jacoby et al.   DRUG DISCOVERY TODAY

Pharmacological repression of PPARγ promotes osteogenesis

(2015) David P. Marciano et al.   Nature Communications

The Therapeutic Potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPARγ, RORs, and Rev-erbs

(2014) David P. Marciano et al.   Cell Metabolism

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

(2014) David P Marciano et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

(2014) Joong Sup Shim et al.   International Journal of Biological Sciences

PPAR  Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

(2014) J. B. Jahrling et al.   JOURNAL OF NEUROSCIENCE

Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

(2013) Samy A.F. Morad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoid X Receptor Agonists Impair Arterial Mononuclear Cell Recruitment through Peroxisome Proliferator-Activated Receptor-  Activation

(2012) M.-J. Sanz et al.   JOURNAL OF IMMUNOLOGY

Chemical Proteomics-Based Analysis of Off-Target Binding Profiles for Rosiglitazone and Pioglitazone: Clues for Assessing Potential for Cardiotoxicity

(2012) Brian R. Hoffmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

New cures sought from old drugs

(2012) Meredith Wadman   NATURE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Modulation of RXR function through ligand design

(2011) Efrén Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Organotins Are Potent Activators of PPARγ and Adipocyte Differentiation in Bone Marrow Multipotent Mesenchymal Stromal Cells

(2011) Susan C. Yanik et al.   TOXICOLOGICAL SCIENCES

Retinoid X receptors: common heterodimerization partners with distinct functions

(2010) Philippe Lefebvre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM