Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

(2020) Bing Zhang et al.   NATURE

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

(2020) Helen Ray-Jones et al.   BMC BIOLOGY

Tracing the Evolutionary Origin of Desmosomes

(2020) Kathleen J. Green et al.   CURRENT BIOLOGY

HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity

(2020) Katherine M. Szigety et al.   GENES & DEVELOPMENT

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

(2020) Sampath K. Loganathan et al.   SCIENCE

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

(2020) Yulia Shwartz et al.   CELL

De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma

(2019) Ana Sastre-Perona et al.   Cell Stem Cell

The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin

(2019) Emanuel Rognoni et al.   Cells

Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

(2019) Kefei Nina Li et al.   eLife

The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

(2019) Nina Oberbeck et al.   NATURE

Stem cell–driven lymphatic remodeling coordinates tissue regeneration

(2019) Shiri Gur-Cohen et al.   SCIENCE

Unraveling cancer lineage drivers in squamous cell carcinomas

(2019) Yinglu Guan et al.   PHARMACOLOGY & THERAPEUTICS

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

(2018) Amy F. Chen et al.   Cell Stem Cell

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

(2018) Yejing Ge et al.   NATURE REVIEWS GENETICS

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

(2018) Joshua D. Campbell et al.   Cell Reports

Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin

(2018) Xiying Fan et al.   DEVELOPMENTAL CELL

In vivo reprogramming of wound-resident cells generates skin epithelial tissue

(2018) Masakazu Kurita et al.   NATURE

JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

(2018) Karmveer Singh et al.   Nature Communications

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein

(2017) Rasoul Pourebrahim et al.   GENES & DEVELOPMENT

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

(2017) Thomas Vierbuchen et al.   MOLECULAR CELL

Lineage-specific dynamic and pre-established enhancer–promoter contacts cooperate in terminal differentiation

(2017) Adam J Rubin et al.   NATURE GENETICS

Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

(2017) Lorenzo Rinaldi et al.   eLife

The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches

(2016) Brett Shook et al.   Annual Review of Cell and Developmental Biology

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

(2016) Lorenzo Rinaldi et al.   Cell Stem Cell

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

(2016) Katherine L. Dauber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

(2015) Rene C. Adam et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21∗ in SCC progression

(2015) Yejing Ge et al.   NATURE CELL BIOLOGY

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Merkel cells and neurons keep in touch

(2015) Seung-Hyun Woo et al.   TRENDS IN CELL BIOLOGY

ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

(2015) Hanseul Yang et al.   eLife

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Ovol Proteins: Guardians against EMT during Epithelial Differentiation

(2014) Shan Li et al.   DEVELOPMENTAL CELL

ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

(2014) Lisa D. Boxer et al.   GENES & DEVELOPMENT

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

(2014) Stefanie Wurm et al.   GENES & DEVELOPMENT

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

(2014) Hideo Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia

(2014) William M. Gordon et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin

(2014) Michal Mlacki et al.   PLoS One

Targeting miR-21 to Treat Psoriasis

(2014) J. Guinea-Viniegra et al.   Science Translational Medicine

SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma

(2014) Jasmin M. Siegle et al.   Nature Communications

Epigenetic Regulation of Epidermal Differentiation

(2014) C. N. Perdigoto et al.   Cold Spring Harbor Perspectives in Medicine

Sweat Gland Progenitors in Development, Homeostasis, and Wound Repair

(2014) C. Lu et al.   Cold Spring Harbor Perspectives in Medicine

Dominant Mutations in GRHL3 Cause Van der Woude Syndrome and Disrupt Oral Periderm Development

(2013) Myriam Peyrard-Janvid et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4

(2013) Xiaomin Bao et al.   Cell Stem Cell

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells

(2013) A. N. Mardaryev et al.   DEVELOPMENT

Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation

(2013) S. J. Jackson et al.   DEVELOPMENT

Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

(2013) E. M. Briso et al.   GENES & DEVELOPMENT

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

(2013) Helia B. Schonthaler et al.   IMMUNITY

Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

(2013) Michael W. Hughes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway

(2013) Dongmei Wang et al.   NATURE CELL BIOLOGY

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

(2013) X. Ding et al.   Science Signaling

Genomic Profiling of a Human Organotypic Model of AEC Syndrome Reveals ZNF750 as an Essential Downstream Target of Mutant TP63

(2012) Brian J. Zarnegar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin

(2012) Shadmehr Demehri et al.   CANCER CELL

Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting

(2012) Matteo Di Piazza et al.   CANCER CELL

The Harmonies Played by TGF-β in Stem Cell Biology

(2012) Naoki Oshimori et al.   Cell Stem Cell

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17

(2012) Juan Guinea-Viniegra et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

(2012) Motonobu Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

(2012) Ji Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development

(2012) Rita M. Quintana et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Diverse epigenetic strategies interact to control epidermal differentiation

(2012) Klaas W. Mulder et al.   NATURE CELL BIOLOGY

Chromatin regulators in mammalian epidermis

(2012) Michaela Frye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling

(2012) Rachel Sennett et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Development and homeostasis of the sebaceous gland

(2012) Catherin Niemann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

(2012) Amelia Soto Hopkin et al.   PLoS Genetics

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

(2011) Peter C. Hollenhorst et al.   Annual Review of Biochemistry

 Np63 Versatilely Regulates a Broad NF- B Gene Program and Promotes Squamous Epithelial Proliferation, Migration, and Inflammation

(2011) X. Yang et al.   CANCER RESEARCH

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

(2011) Hironobu Fujiwara et al.   CELL

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4

(2011) Nuno Miguel Luis et al.   Cell Stem Cell

Committing to a Hairy Fate: Epigenetic Regulation of Hair Follicle Stem Cells

(2011) Sarah E. Millar   Cell Stem Cell

Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

(2011) Isaac Brownell et al.   Cell Stem Cell

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

p63 regulatesSatb1to control tissue-specific chromatin remodeling during development of the epidermis

(2011) Michael Y. Fessing et al.   JOURNAL OF CELL BIOLOGY

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Regulation of p53 Family Member Isoform  Np63  by the Nuclear Factor- B Targeting Kinase I B Kinase  

(2010) A. Chatterjee et al.   CANCER RESEARCH

 Np63  Repression of the Notch1 Gene Supports the Proliferative Capacity of Normal Human Keratinocytes and Cervical Cancer Cells

(2010) T. Yugawa et al.   CANCER RESEARCH

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

(2010) Beate M. Lichtenberger et al.   CELL

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity

(2010) Yeliz Boglev et al.   DEVELOPMENTAL BIOLOGY

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

(2010) Jingxuan Yang et al.   JOURNAL OF CELL BIOLOGY

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

(2010) Francesca Moretti et al.   JOURNAL OF CLINICAL INVESTIGATION

DNMT1 maintains progenitor function in self-renewing somatic tissue

(2010) George L. Sen et al.   NATURE

Opposing roles for calcineurin and ATF3 in squamous skin cancer

(2010) Xunwei Wu et al.   NATURE

Epithelial decision makers: in search of the 'epimmunome'

(2010) Mahima Swamy et al.   NATURE IMMUNOLOGY

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets

(2010) R Ehsanian et al.   ONCOGENE

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Phosphorylation of Grainy head by ERK is essential for wound-dependent regeneration but not for development of an epidermal barrier

(2010) M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

(2010) Veronica G. Beaudry et al.   PLoS Genetics

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf

(2009) Xiaohua Su et al.   EMBO JOURNAL

Ets1 Induces Dysplastic Changes When Expressed in Terminally-Differentiating Squamous Epidermal Cells

(2009) Priyadharsini Nagarajan et al.   PLoS One

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Multiple transcription factor codes activate epidermal wound-response genes in Drosophila

(2009) J. C. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 Homologue  Np63  Interacts with the Nuclear Factor- B Pathway to Modulate Epithelial Cell Growth

(2008) K. E. King et al.   CANCER RESEARCH

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

(2008) Y Li et al.   CELL DEATH AND DIFFERENTIATION

miR-203 represses ‘stemness’ by repressing ΔNp63

(2008) A M Lena et al.   CELL DEATH AND DIFFERENTIATION

Activation of  -catenin signaling programs embryonic epidermis to hair follicle fate

(2008) Y. Zhang et al.   DEVELOPMENT

Grhl3 and Lmo4 play coordinate roles in epidermal migration

(2008) Nikki R. Hislop et al.   DEVELOPMENTAL BIOLOGY

Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3

(2008) G. L. Sen et al.   GENES & DEVELOPMENT

Skin stem cells: rising to the surface

(2008) Elaine Fuchs   JOURNAL OF CELL BIOLOGY

IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal Dysplasias

(2008) Barbara Marinari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

(2008) Vihren Kolev et al.   NATURE CELL BIOLOGY

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation

(2008) Arabella Meixner et al.   NATURE CELL BIOLOGY

Disruption of an AP-2α binding site in an IRF6 enhancer is associated with cleft lip

(2008) Fedik Rahimov et al.   NATURE GENETICS

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch tumor suppressor function

(2008) G P Dotto   ONCOGENE

Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development

(2008) Teresa Lopardo et al.   PLoS One

The tumor suppressor activity of IKK  in stratified epithelia is exerted in part via the TGF-  antiproliferative pathway

(2008) B. Marinari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKK  is a critical coregulator of a Smad4-independent TGF -Smad2/3 signaling pathway that controls keratinocyte differentiation

(2008) P. Descargues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phylogeny of the Hair Follicle: The Sebogenic Hypothesis

(2007) K.S. Stenn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY