Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32
Volume 32, Issue -, Pages 609-631Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-111315-125426
Keywords
adipose tissue; regeneration; skin; adipocyte
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Funding
- NCATS NIH HHS [UL1 TR001863] Funding Source: Medline
- NIAMS NIH HHS [R01 AR060295, R01 AR069550] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007223] Funding Source: Medline
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Classically, white adipose tissue (WAT) was considered an inert component of connective tissue but is now appreciated as a major regulator of metabolic physiology and endocrine homeostasis. Recent work defining how WAT develops and expands in vivo emphasizes the importance of specific locations of WAT or depots in metabolic regulation. Interestingly, mature white adipocytes are integrated into several tissues. A new perspective regarding the in vivo regulation and function of WAT in these tissues has highlighted an essential role of adipocytes in tissue homeostasis and regeneration. Finally, there has been significant progress in understanding how mature adipocytes regulate the pathology of several diseases. In this review, we discuss these novel roles of WAT in the homeostasis and regeneration of epithelial, muscle, and immune tissues and how they contribute to the pathology of several disorders.
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