Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease

Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or β-Amyloidosis

(2017) Jerzy Wegiel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer’s disease, a case report

(2017) Claudio D’Addario et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

(2017) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia

(2016) Elena Ceccacci et al.   BRITISH JOURNAL OF CANCER

Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain

(2016) Yara Pujol Lopez et al.   MOLECULAR BIOLOGY REPORTS

Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment

(2016) Elliott J. Mufson et al.   NEUROBIOLOGY OF AGING

Braak stage and trajectory of cognitive decline in noncognitively impaired elders

(2016) Elliott J. Mufson et al.   NEUROBIOLOGY OF AGING

Causal evidence for frontal cortex organization for perceptual decision making

(2016) Dobromir Rahnev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into neuroepigenetics through human histone deacetylase PET imaging

(2016) Hsiao-Ying Wey et al.   Science Translational Medicine

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

(2016) Jintao Bao et al.   Protein & Cell

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

(2016) Jeffrey A. Blair et al.   PLoS One

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

(2015) Morgan E Levine et al.   Aging-US

Epigenetics of Aging and Alzheimer’s Disease: Implications for Pharmacogenomics and Drug Response

(2015) Ramón Cacabelos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment

(2015) Sylvia E. Perez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition

(2015) Jagannath Behera et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain

(2015) Kyle W. Anderson et al.   PLoS One

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

(2014) F. A. Schroeder et al.   ACS Chemical Neuroscience

Early Failure of the Default-Mode Network and the Pathogenesis of Alzheimer's Disease

(2014) Goran Simic et al.   CNS Neuroscience & Therapeutics

Histone Deacetylase 6 Is a FoxO Transcription Factor-dependent Effector in Skeletal Muscle Atrophy

(2014) Francesca Ratti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies

(2014) Mark E. Glickman et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

(2014) Changning Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

(2014) Lydia Pernet et al.   MOLECULAR BIOLOGY OF THE CELL

SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

(2014) Rogier van Gent et al.   PLoS One

The role of autophagy in Alzheimer's disease

(2013) Miranda Orr et al.   Alzheimers & Dementia

The role of ATM and DNA damage in neurons: Upstream and downstream connections

(2013) Karl Herrup et al.   DNA REPAIR

Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

(2013) M. J. Morris et al.   JOURNAL OF NEUROSCIENCE

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

Sirtuin1: A Promising Serum Protein Marker for Early Detection of Alzheimer’s Disease

(2013) Rahul Kumar et al.   PLoS One

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

(2013) Mei-Jen Chuang et al.   PLoS One

Prefrontal cortical microcircuits bind perception to executive control

(2013) Ioan Opris et al.   Scientific Reports

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

(2012) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

(2012) Farah H. Bardai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Prefrontal Contributions to Metacognition in Perceptual Decision Making

(2012) S. M. Fleming et al.   JOURNAL OF NEUROSCIENCE

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

(2012) M.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

HDAC1 Regulates Fear Extinction in Mice

(2012) S. Bahari-Javan et al.   JOURNAL OF NEUROSCIENCE

G9a/GLP Histone Lysine Dimethyltransferase Complex Activity in the Hippocampus and the Entorhinal Cortex Is Required for Gene Activation and Silencing during Memory Consolidation

(2012) S. Gupta-Agarwal et al.   JOURNAL OF NEUROSCIENCE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease

(2012) Steven E. Arnold et al.   NEUROBIOLOGY OF AGING

Hippocampal Drebrin Loss in Mild Cognitive Impairment

(2012) Scott E. Counts et al.   Neurodegenerative Diseases

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease

(2011) Sylvia E. Perez et al.   AMERICAN JOURNAL OF PATHOLOGY

Autodeimination of Protein Arginine Deiminase 4 Alters Protein–Protein Interactions but Not Activity

(2011) Jessica L. Slack et al.   BIOCHEMISTRY

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

(2011) Terence K. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Prior Expectation Modulates the Interaction between Sensory and Prefrontal Regions in the Human Brain

(2011) D. Rahnev et al.   JOURNAL OF NEUROSCIENCE

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

(2010) Sigeng Chen et al.   PLoS One

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

(2009) Sajid Rashid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tau - an inhibitor of deacetylase HDAC6 function

(2009) Mar Perez et al.   JOURNAL OF NEUROCHEMISTRY

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells

(2009) Sabrina Fritah et al.   MOLECULAR BIOLOGY OF THE CELL

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Factors associated with resistance to dementia despite high Alzheimer disease pathology

(2009) D. Erten-Lyons et al.   NEUROLOGY

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

UV Radiation Regulates Mi-2 through Protein Translation and Stability

(2008) Craig J. Burd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity

(2008) Mahesh P. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON