Benzisoxazole: a privileged scaffold for medicinal chemistry

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis

(2017) Ann L. Walker et al.   JOURNAL OF MEDICINAL CHEMISTRY

What is medicinal chemistry? – Demystifying a rapidly evolving discipline!

(2017) Selina Y. L. Holbrook et al.   MedChemComm

New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities

(2017) Aida Chaker et al.   Arabian Journal of Chemistry

Seeking potent anti-tubercular agents: Design, synthesis, anti-tubercular activity and docking study of various ((triazoles/indole)-piperazin-1-yl/1,4-diazepan-1-yl)benzo[d]isoxazole derivatives

(2016) Kalaga Mahalakshmi Naidu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics

(2016) Xudong Cao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

(2015) Nanjundaswamy Ashwini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

(2015) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of amide, sulfonamide and urea – benzisoxazole derivatives as potential atypical antipsychotics

(2015) Yin Chen et al.   MedChemComm

Design, synthesis and biological evaluation of 5-(2-(4-(substituted benzo[d]isoxazol-3-yl)piperazin-1-yl)acetyl)indolin-2-one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues as novel anti-tubercular agents

(2015) Kalaga Mahalakshmi Naidu et al.   Arabian Journal of Chemistry

Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

(2015) Alimuddin Zumla et al.   Lancet Respiratory Medicine

“Old Friends in New Guise”: Exploiting Privileged Structures for Scaffold Re-Evolution/Refining

(2014) Yu'ning Song et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Design, synthesis and antimycobacterial activity of various 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[d]isoxazole derivatives

(2014) Kalaga Mahalakshmi Naidu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of new of 3-(benzo[d]isoxazol-3-yl)-1-substituted pyrrolidine-2, 5-dione derivatives as anticonvulsants

(2014) Sachin Malik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics

(2014) Yin Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

(2014) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and evaluation of antioxidant and anticancer activities of novel benzisoxazole-substituted-allyl derivatives

(2014) Mohanam Anand et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

Heterocycle-thioacetic Acid Motif: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activities

(2013) Yu’ning Song et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics

(2013) Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

(2013) Qing Ye et al.   MOLECULES

Evaluation of antimycobacterial activity of a sulphonamide derivative

(2013) Vanessa Albertina Agertt et al.   TUBERCULOSIS

The biology and chemistry of antifungal agents: A review

(2012) Muthu K Kathiravan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heterocycles in drugs and drug discovery

(2012) A. Gomtsyan   Chemistry of Heterocyclic Compounds

Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue – Synthesis and structure–activity studies

(2012) C.S. Shantharam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Multiple 5-HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease

(2012) Michael A. Brodney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

(2011) Shogo Sakuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles – A new class of promising antimicrobials

(2011) R. Suhas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators

(2011) Weiguo Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents

(2011) Z. Li et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials – A novel approach to enhance biocompatibility

(2010) R. Suhas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Induced Stabilization and Activation of Peroxisome Proliferator-Activated Receptor γ

(2008) Osman A. B. S. M. Gani et al.   Chemical Biology & Drug Design

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

(2008) Bo-Liang Deng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial studies of novel methylene bridged benzisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives

(2008) Ravi S. Lamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: A structure–activity relationship study

(2008) S. B. Benaka Prasad et al.   INVESTIGATIONAL NEW DRUGS

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90

(2008) Ariamala Gopalsamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs

(2008) Subash Velaparthi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics

(2008) Reyes Aranda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)(1)

(2008) Stefania Aiello et al.   JOURNAL OF MEDICINAL CHEMISTRY