Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

(2018) Adam Cribbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming

(2018) Qiang Zhuang et al.   NATURE CELL BIOLOGY

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

(2018) Cian J. Lynch et al.   Cell Reports

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

(2018) Ryan Raisner et al.   Cell Reports

Transcription factor dimerization activates the p300 acetyltransferase

(2018) Esther Ortega et al.   NATURE

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2017) Loren M. Lasko et al.   NATURE

Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation

(2017) Sangho Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation

(2016) Zoltan Simandi et al.   MOLECULAR CELL

Transcriptional Control of Somatic Cell Reprogramming

(2016) Yan Xu et al.   TRENDS IN CELL BIOLOGY

Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains

(2016) Zhicheng Shao et al.   Cell Reports

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

(2016) Andrew R Conery et al.   eLife

Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage

(2016) Steven A. Jackson et al.   Stem Cell Reports

High-density P300 enhancers control cell state transitions

(2015) Steven Witte et al.   BMC GENOMICS

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

(2015) S. Picaud et al.   CANCER RESEARCH

A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming

(2015) Yang Zhao et al.   CELL

The histone chaperone CAF-1 safeguards somatic cell identity

(2015) Sihem Cheloufi et al.   NATURE

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

(2015) Ariane Hammitzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF)

(2015) Kerem Fidan et al.   Stem Cell Research

CGAT: computational genomics analysis toolkit

(2014) D. Sims et al.   BIOINFORMATICS

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

(2014) Duncan A. Hay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Notch inhibition allows oncogene-independent generation of iPS cells

(2014) Justin K Ichida et al.   Nature Chemical Biology

Coactivators p300 and CBP Maintain the Identity of Mouse Embryonic Stem Cells by Mediating Long-Range Chromatin Structure

(2014) Fang Fang et al.   STEM CELLS

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Epigenetics of Reprogramming to Induced Pluripotency

(2013) Bernadett Papp et al.   CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

(2013) Manuela Delvecchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research

(2013) Catherine Y. Seiler et al.   NUCLEIC ACIDS RESEARCH

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

The Transcription Factor Paired-Related Homeobox 1 (Prrx1) Inhibits Adipogenesis by Activating Transforming Growth Factor-β (TGFβ) Signaling

(2012) Baowen Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

The EP300, KDM5A, KDM6A and KDM6B Chromatin Regulators Cooperate with KLF4 in the Transcriptional Activation of POU5F1

(2012) Wan-Ping Wang et al.   PLoS One

Discovery of Nonsteroidal Anti-Inflammatory Drug and Anticancer Drug Enhancing Reprogramming and Induced Pluripotent Stem Cell Generation

(2011) Chao-Shun Yang et al.   STEM CELLS

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Roles of Coactivator p300 in Mouse Embryonic Stem Cell Differentiation and Nanog Expression

(2009) Xiaomin Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

(2008) Lei Zeng et al.   STRUCTURE