Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

Genista sessilifoliaDC. extracts induce apoptosis across a range of cancer cell lines

(2013) P. Bontempo et al.   CELL PROLIFERATION

Histone deacetylases as targets for treatment of multiple diseases

(2013) Jinhua Tang et al.   CLINICAL SCIENCE

Histone Acetylation: From Code to Web and Router Via Intrinsically Disordered Regions

(2013) Masami Horikoshi   CURRENT PHARMACEUTICAL DESIGN

Structure and mechanism of non-histone protein acetyltransferase enzymes

(2013) David R. Friedmann et al.   FEBS Journal

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The thiazole derivative CPTH6 impairs autophagy

(2013) Y Ragazzoni et al.   Cell Death & Disease

Romidepsin: A Histone Deacetylase Inhibitor for Refractory Cutaneous T-Cell Lymphoma

(2012) Miryoung Kim et al.   ANNALS OF PHARMACOTHERAPY

P300/CBP Associated Factor Regulates Nitroglycerin-Dependent Arterial Relaxation by N ε -Lysine Acetylation of Contractile Proteins

(2012) Claudia Colussi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear

(2012) W. Wei et al.   JOURNAL OF NEUROSCIENCE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

(2011) Silviya D. Furdas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)

(2011) Ciro Milite et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

(2011) D. Trisciuoglio et al.   CLINICAL CANCER RESEARCH

Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

(2011) H. Korkaya et al.   CLINICAL CANCER RESEARCH

High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

(2011) Mei Li et al.   Journal of Translational Medicine

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

(2011) A. Nebbioso et al.   MOLECULAR CANCER THERAPEUTICS

N -lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

(2011) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

(2010) Massimo Ghizzoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Identification of a Novel Natural Activator of p300 Histone Acetyltranferase Provides New Insights into the Modulation Mechanism of this Enzyme

(2010) Fabrizio Dal Piaz et al.   CHEMBIOCHEM

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Nitric Oxide-Mediated Histone Hyperacetylation in Oral Cancer: Target for a Water-Soluble HAT Inhibitor, CTK7A

(2010) Mohammed Arif et al.   CHEMISTRY & BIOLOGY

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases

(2010) David C. Bedford et al.   Epigenetics

RETRACTED: Intracellular distribution of p300 and its differential recruitment to aggresomes in breast cancer

(2010) María E. Fermento et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound

(2010) Roberta Ruotolo et al.   GENOMICS

Small-molecule chromatin-modifying agents: therapeutic applications

(2010) Antonello Mai   Epigenomics

Inhibition of Lysine Acetyltransferase KAT3B/p300 Activity by a Naturally Occurring Hydroxynaphthoquinone, Plumbagin

(2009) Kodihalli C. Ravindra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Sirt2 by p300 attenuates its deacetylase activity

(2008) Younho Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases

(2008) Gianluca Sbardella et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

(2008) Antonello Mai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities

(2008) José A. Souto et al.   ChemMedChem

Catalysis and substrate selection by histone/protein lysine acetyltransferases

(2008) Christopher E Berndsen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function

(2008) Ling Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors

(2008) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

The SIRT2 Deacetylase Regulates Autoacetylation of p300

(2008) Joshua C. Black et al.   MOLECULAR CELL

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE