Hypoxia and hypoxia-inducible factors in diabetes and its complications

Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice

(2020) Mai Sugahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes.

(2020) Carissa Vinovskis et al.   DIABETES

Recent Advances in Epigenetics of Macrovascular Complications in Diabetes Mellitus

(2020) Mingchang Pang et al.   Heart Lung and Circulation

Hypoxia-inducible factors and diabetes

(2020) Jenny E. Gunton   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats

(2019) Yu Zhu et al.   WOUND REPAIR AND REGENERATION

Roxadustat: First Global Approval

(2019) Sohita Dhillon   DRUGS

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

(2019) Amit Lalwani et al.   Cell Reports

Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy

(2019) Neda Rajamand Ekberg et al.   Journal of Diabetes Research

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

(2019) Hiroshi Nomoto et al.   DIABETOLOGIA

Mechanism and Consequences of The Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose

(2019) Coral García-Pastor et al.   Scientific Reports

Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction

(2019) Motahareh Zeinivand et al.   INFLAMMOPHARMACOLOGY

Non-invasive assessment of early stage diabetic nephropathy by DTI and BOLD MRI

(2019) You-Zhen Feng et al.   BRITISH JOURNAL OF RADIOLOGY

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge

(2018) Sho Koyasu et al.   CANCER SCIENCE

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease

(2018) Maria da Luz Sousa Fialho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.

(2018) Daniel Rangel Rojas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A compendium of proteins that interact with HIF-1α

(2017) Gregg L. Semenza   EXPERIMENTAL CELL RESEARCH

Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection

(2017) Lin Cheng et al.   Frontiers in Cellular Neuroscience

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of AtherosclerosisSignificance

(2016) Lea Rahtu-Korpela et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers

(2015) Sivakamasundari Pichu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells

(2015) Renzhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion

(2014) Zoi Michailidou et al.   DIABETES

HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

(2014) L. Rahtu-Korpela et al.   DIABETES

Transdermal deferoxamine prevents pressure-induced diabetic ulcers

(2014) Dominik Duscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

(2012) Rebecca A. Stokes et al.   CELL TRANSPLANTATION

Impact of the Hypoxia-Inducible Factor-1   (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy

(2012) H. F. Gu et al.   DIABETES CARE

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretionin Vitro

(2011) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury

(2010) Jaana Hyvärinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

(2010) Kim Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

(2009) H. Thangarajah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

(2008) C. Regazzetti et al.   DIABETES

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES

pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic   cells

(2008) J. Zehetner et al.   GENES & DEVELOPMENT

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice

(2008) James Cantley et al.   JOURNAL OF CLINICAL INVESTIGATION

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA