Type I interferon in the pathogenesis of systemic lupus erythematosus

Lessons from precision medicine in rheumatology

(2020) Theresa L Wampler Muskardin et al.   Multiple Sclerosis Journal

Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions

(2020) Tanja Fetter et al.   Frontiers in Immunology

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

B cell–intrinsic TLR9 expression is protective in murine lupus

(2020) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

(2020) Leonhard X. Heinz et al.   NATURE

Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

(2019) Carolina Uggenti et al.   Annual Review of Immunology

Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus

(2019) Richard Furie et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture

(2019) Lin Gao et al.   CYTOKINE

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

Genome-Wide DNA Methylation Profiles Reveal Common Epigenetic Patterns of Interferon-Related Genes in Multiple Autoimmune Diseases

(2019) Sidi Chen et al.   Frontiers in Genetics

Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells

(2019) Sonya J. Wolf et al.   JOURNAL OF AUTOIMMUNITY

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

(2019) Christopher A. Odhams et al.   Nature Communications

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

(2019) Simon H. Jiang et al.   Nature Communications

Ultrasensitive serum interferon-α quantification during SLE remission identifies patients at risk for relapse

(2019) Alexis Mathian et al.   ANNALS OF THE RHEUMATIC DISEASES

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity

(2019) Olivia Majer et al.   NATURE

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

(2019) Senthil Kumaran Satyanarayanan et al.   Nature Communications

IFN-α kinoid in systemic lupus erythematosus: results from a phase IIb, randomised, placebo-controlled study

(2019) Frederic A Houssiau et al.   ANNALS OF THE RHEUMATIC DISEASES

A Successful Trial for Lupus — How Good Is Good Enough?

(2019) Jane E. Salmon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

TheSTAT4SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE

(2018) Niklas Hagberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

(2018) Mrinal K Sarkar et al.   ANNALS OF THE RHEUMATIC DISEASES

Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes

(2018) Clio P. Mavragani et al.   JOURNAL OF AUTOIMMUNITY

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Daniel J Wallace et al.   LANCET

Type I interferon in rheumatic diseases

(2018) Theresa L. Wampler Muskardin et al.   Nature Reviews Rheumatology

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response

(2018) John T. Crowl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal association of type 1 interferon-induced chemokines with disease activity in systemic lupus erythematosus

(2018) K. L. Connelly et al.   Scientific Reports

DNA as a self-antigen: nature and regulation

(2018) Chetna Soni et al.   CURRENT OPINION IN IMMUNOLOGY

Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition

(2018) Rosana Gonzalez-Quintial et al.   PLoS One

Transancestral mapping and genetic load in systemic lupus erythematosus

(2017) Carl D. Langefeld et al.   Nature Communications

Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells

(2017) Yogita Ghodke-Puranik et al.   Arthritis & Rheumatology

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Drugs in early clinical development for Systemic Lupus Erythematosus

(2016) Mariana Postal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting type I interferon in systemic lupus erythematosus

(2016) Timothy B. Niewold   Nature Reviews Rheumatology

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunogenetics of systemic lupus erythematosus: A comprehensive review

(2015) Yogita Ghodke-Puranik et al.   JOURNAL OF AUTOIMMUNITY

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus

(2014) S N Kariuki et al.   GENES AND IMMUNITY

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

TLRs and interferons: a central paradigm in autoimmunity

(2013) Dwight H. Kono et al.   CURRENT OPINION IN IMMUNOLOGY

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

(2013) Patrick Coit et al.   JOURNAL OF AUTOIMMUNITY

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

(2013) R. Baccala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

(2012) Mark A Jensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus

(2012) Yelena Koldobskaya et al.   Clinical & Developmental Immunology

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

(2011) Lauren L. Ritterhouse et al.   ARTHRITIS AND RHEUMATISM

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-  and Serologic Autoimmunity in Lupus Patients

(2011) T. Robinson et al.   JOURNAL OF IMMUNOLOGY

Interferon Alpha as a Primary Pathogenic Factor in Human Lupus

(2011) Timothy B. Niewold   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Familial Aggregation of Autoimmune Disease in Juvenile Dermatomyositis

(2011) T. B. Niewold et al.   PEDIATRICS

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

(2010) Corinna E. Weckerle et al.   ARTHRITIS AND RHEUMATISM

The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

(2010) Corinna E. Weckerle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

(2010) Isaac T. W. Harley et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

(2010) Silvia N Kariuki et al.   ARTHRITIS RESEARCH & THERAPY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM