Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer’s disease

Rational Design of Two-photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues

(2020) Haixiao Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer’s Enzyme Biomarkers-BACE1 and Cathepsin D

(2020) Jenny M. Tam et al.   MOLECULES

Observation of Acetylcholinesterase in Stress-induced Depression Phenotypes by Two-photon Fluorescence Imaging in the Mouse Brain

(2019) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Near-Infrared AIE-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultra-Sensitivity and High-Fidelity

(2019) Wei Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Mitochondrion-Targeting Fluorescence Probe via Reduction Induced Charge Transfer for Fast Methionine Sulfoxide Reductases Imaging

(2019) Mei-Hao Xiang et al.   ANALYTICAL CHEMISTRY

Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes

(2019) Xiaofeng Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Versatile fluorescent probes for visualizing superoxide anion in living cells and in vivo

(2019) Haibin Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

(2019) Luling Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent progress in two-photon small molecule fluorescent probes for enzymes

(2019) Ding Chen et al.   CHINESE CHEMICAL LETTERS

Detection of Selenocysteine with a Ratiometric near-Infrared Fluorescent Probe in Cells and in Mice Thyroid Diseases Model

(2019) Xianzhu Luo et al.   ANALYTICAL CHEMISTRY

Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer’s disease

(2019) Yusif Issahak Gyasi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ratiometric Near-Infrared Fluorescent Probe for Synergistic Detection of Monoamine Oxidase B and Its Contribution to Oxidative Stress in Cell and Mice Aging Models

(2018) Rui Wang et al.   ANALYTICAL CHEMISTRY

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

(2018) Peter Verwilst et al.   CHEMICAL SOCIETY REVIEWS

Fluorescent probes for the simultaneous detection of multiple analytes in biology

(2018) Jacek L. Kolanowski et al.   CHEMICAL SOCIETY REVIEWS

Novel strategy of constructing fluorescent probe for MAO-B via cascade reaction and its application in imaging MAO-B in human astrocyte

(2018) Huihuan Qin et al.   CHINESE CHEMICAL LETTERS

Biomarker-targeted fluorescent probes for breast cancer imaging

(2018) Dongfang Yue et al.   CHINESE CHEMICAL LETTERS

Development of a Ratiometric Fluorescent Probe with Two ­Reactive Sulfoxides for Monitoring the Activity of Methionine Sulfoxide Reductase A

(2018) Jiří Míšek et al.   SYNTHESIS-STUTTGART

A peptide–WS2 nanosheet based biosensing platform for determination of β-secretase and screening of its inhibitors

(2018) Xianwei Zuo et al.   ANALYST

Novel fluorescence probes based on the chalcone scaffold for in vitro staining of β-amyloid plaques

(2018) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo Detection of Amyloid Plaques in the Mouse Brain using the Near-Infrared Fluorescence Probe THK-265

(2018) Nobuyuki Okamura et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes

(2018) Hiroyuki Watanabe et al.   Molecular Imaging

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

(2018) Jing Ning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bright and sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage due to FA in various living systems

(2017) Kun Dou et al.   Chemical Science

A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease

(2017) Liangwei Zhang et al.   Chemical Science

Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging

(2016) Hualong Fu et al.   ANALYTICAL CHEMISTRY

A Ratiometric Fluorescent Probe for Imaging of the Activity of Methionine Sulfoxide Reductase A in Cells

(2016) Nikolai Makukhin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

(2016) Guanglei Lv et al.   CHEMICAL COMMUNICATIONS

Recent Development of Chemosensors Based on Cyanine Platforms

(2016) Wen Sun et al.   CHEMICAL REVIEWS

Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species

(2016) Xiaoqiang Chen et al.   CHEMICAL SOCIETY REVIEWS

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques

(2016) Cheol Ho Heo et al.   Chemical Science

Red emission fluorescent probes for visualization of monoamine oxidase in living cells

(2016) Ling-Ling Li et al.   Scientific Reports

Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice

(2016) Adam B. Salmon et al.   Redox Biology

Sensitive and Selective Ratiometric Fluorescence Probes for Detection of Intracellular Endogenous Monoamine Oxidase A

(2015) Xiaofeng Wu et al.   ANALYTICAL CHEMISTRY

A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

(2015) Lin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

(2015) Hiroyuki Watanabe et al.   CHEMICAL COMMUNICATIONS

Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer’s Disease

(2015) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

(2015) Dokyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A graphene oxide-based fluorescent scheme for the determination of the activity of the β-site amyloid precursor protein (BACE1) and its inhibitors

(2015) Lin Liu et al.   MICROCHIMICA ACTA

Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters

(2015) Junjun Luo et al.   MICROCHIMICA ACTA

A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

(2015) Kwang-su Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease

(2015) Hongjuan Tong et al.   Acta Pharmaceutica Sinica B

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

(2014) Masha G. Savelieff et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visualization of monoamine oxidases in living cells using “Turn-ON” fluorescence resonance energy transfer probes

(2014) Xuefeng Li et al.   ANALYST

Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

(2014) Hualong Fu et al.   CHEMICAL COMMUNICATIONS

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

(2014) Kirsten L. Viola et al.   Nature Nanotechnology

Fluorescent probes for detecting monoamine oxidase activity and cell imaging

(2014) Xuefeng Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

(2014) G.S.M. Sundaram et al.   ORGANIC LETTERS

A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models

(2014) Lin Li et al.   Nature Communications

Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

(2014) Michelle T Fodero-Tavoletti et al.   Alzheimers Research & Therapy

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

(2013) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The design and synthesis of novel “turn-on” fluorescent probes to visualize monoamine oxidase-B in living cells

(2013) Yumi Xiang et al.   RSC Advances

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Fluorogenic Quantum Dot-Gold Nanoparticle Assembly for Beta Secretase Inhibitor Screening in Live Cell

(2012) Youngseon Choi et al.   ANALYTICAL CHEMISTRY

Monitoring β-Secretase Activity in Living Cells with a Membrane-Anchored FRET Probe

(2012) Drew S. Folk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity

(2012) Dokyoung Kim et al.   CHEMICAL COMMUNICATIONS

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

(2012) Shaobo Long et al.   CHEMICAL COMMUNICATIONS

A two-photon fluorescent probe for amyloid-β plaques in living mice

(2012) Cheol Ho Heo et al.   CHEMICAL COMMUNICATIONS

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Aminonaphthalene 2-Cyanoacrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-β and Prion Plaques in Brain

(2012) Kevin Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives

(2011) Xiaoqiang Chen et al.   CHEMICAL REVIEWS

Progress in Alzheimer’s disease

(2011) Daniela Galimberti et al.   JOURNAL OF NEUROLOGY

Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

(2011) Kenji Matsumura et al.   MedChemComm

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

(2010) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Push–pull benzothiazole derivatives as probes for detecting β-amyloid plaques in Alzheimer’s brains

(2009) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sequence selective dual-emission detection of (i, i + 1) bis-phosphorylated peptide using diazastilbene-type Zn(ii)-Dpa chemosensor

(2009) Yoshiyuki Ishida et al.   CHEMICAL COMMUNICATIONS

Fluorescent BODIPY-Based Zn(II) Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer’s Disease Patients

(2009) Akio Ojida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overexpression of Methionine Sulfoxide Reductases A and B2 Protects MOLT-4 Cells Against Zinc-Induced Oxidative Stress

(2008) Filipe Cabreiro et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel fluorogenic probe for monoamine oxidase assays

(2008) You You Lu et al.   CHINESE CHEMICAL LETTERS