Monitoring β-Secretase Activity in Living Cells with a Membrane-Anchored FRET Probe

Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors

(2011) Francesca Mancini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

(2011) Yuan Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Principles for designing fluorescent sensors and reporters

(2011) Edward A Lemke et al.   Nature Chemical Biology

Towards Disease-Modifying Treatment of Alzheimers Disease: Drugs Targeting β -Amyloid

(2010) V. Frisardi et al.   Current Alzheimer Research

Upregulation of the α-secretase ADAM10 - risk or reason for hope?

(2010) Kristina Endres et al.   FEBS Journal

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

(2010) Geneviève Evin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

“Clicked” Bivalent Ligands Containing Curcumin and Cholesterol As Multifunctional Aβ Oligomerization Inhibitors: Design, Synthesis, and Biological Characterization

(2010) James A. Lenhart et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1

(2009) Shawn J. Stachel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the “Swedish Mutant” Amyloid Precursor Protein

(2009) Hidekuni Yamakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation

(2009) Amanda Cobos-Correa et al.   Nature Chemical Biology

Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

(2008) Yoshiari Shimmyo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

(2008) Arvi Rauk   DALTON TRANSACTIONS

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease

(2007) Peter J. Crouch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY