Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Unraveling Disease Pathophysiology with Mathematical Modeling

(2020) Brody H. Foy et al.   Annual Review of Pathology-Mechanisms of Disease

Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

(2020) Narciso Couto et al.   DRUG METABOLISM AND DISPOSITION

Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

(2020) Haeyoung Zhang et al.   DRUG METABOLISM AND DISPOSITION

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

(2019) Narciso Couto et al.   MOLECULAR PHARMACEUTICS

Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

(2019) Zubida M. Al-Majdoub et al.   MOLECULAR PHARMACEUTICS

Kilquist syndrome: A novel syndromic hearing loss disorder caused by homozygous deletion of SLC12A2

(2019) Ellen F. Macnamara et al.   HUMAN MUTATION

The regional-specific relative and absolute expression of gut transporters in adult Caucasians: A meta-analysis

(2019) Matthew Harwood et al.   DRUG METABOLISM AND DISPOSITION

Ontogeny of Hepatic Sulfotransferases (SULTs) and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

(2019) Mayur K. Ladumor et al.   DRUG METABOLISM AND DISPOSITION

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

(2019) Bhagwat Prasad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Maximizing the impact of microphysiological systems with in vitro–in vivo translation

(2018) Murat Cirit et al.   LAB ON A CHIP

Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens

(2018) Marek Drozdzik et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Next generation of network medicine: interdisciplinary signaling approaches

(2017) Tamas Korcsmaros et al.   Integrative Biology

Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes

(2017) Ryan Rossner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The classic pathways of thyroid hormone metabolism

(2017) Anne H. van der Spek et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human

(2017) Takanori Akazawa et al.   MOLECULAR PHARMACEUTICS

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects

(2016) Eisuke Miyauchi et al.   MOLECULAR PHARMACEUTICS

Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

(2015) Hajar Al Feteisi et al.   AAPS Journal

The stomach in health and disease

(2015) R H Hunt et al.   GUT

Application of an LC–MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique

(2015) M.D. Harwood et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Absolute Proteome Analysis of Colorectal Mucosa, Adenoma, and Cancer Reveals Drastic Changes in Fatty Acid Metabolism and Plasma Membrane Transporters

(2015) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics

(2014) C. Gröer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

(2014) Marek Drozdzik et al.   MOLECULAR PHARMACEUTICS

PBPK models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Animal versus human oral drug bioavailability: Do they correlate?

(2013) Helen Musther et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

LC–MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins

(2013) C. Gröer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Alternative Fusion Protein Strategies to Express Recalcitrant QconCAT Proteins for Quantitative Proteomics of Human Drug Metabolizing Enzymes and Transporters

(2013) Matthew R. Russell et al.   JOURNAL OF PROTEOME RESEARCH

X-Linked Adrenoleukodystrophy: Molecular and Functional Analysis of the ABCD1 Gene in Argentinean Patients

(2013) Cyntia Anabel Amorosi et al.   PLoS One

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Discovery of SLC3A2 Cell Membrane Protein as a Potential Gastric Cancer Biomarker: Implications in Molecular Imaging

(2012) Yixuan Yang et al.   JOURNAL OF PROTEOME RESEARCH

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

(2012) Jacek R Wiśniewski et al.   Molecular Systems Biology

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

A Comparison of Pharmacokinetics between Humans and Monkeys

(2009) T. Akabane et al.   DRUG METABOLISM AND DISPOSITION

Computational modeling of epithelial tissues

(2009) Rod Smallwood   Wiley Interdisciplinary Reviews-Systems Biology and Medicine