Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes

Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamineN-oxide

(2017) Chun-Yang Li et al.   MOLECULAR MICROBIOLOGY

Emerging roles of xenobiotic detoxification enzymes in metabolic diseases

(2017) Michael C. Petriello et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases

(2016) Maria Laura Mascotti et al.   JOURNAL OF MOLECULAR BIOLOGY

Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis

(2016) Lenka Tomasova et al.   MOLECULES

C. elegansflavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress

(2016) Nisha Hirani et al.   Biology Open

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients

(2016) Cassianne Robinson-Cohen et al.   PLoS One

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

(2015) Sandra G. Gonzalez Malagon et al.   BIOCHEMICAL PHARMACOLOGY

Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular Injury in Hemodialysis Patients

(2015) Kei Fukami et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Preliminary study of FMO1, FMO5, CYP21, ESR1, PLIN2 and SULT2A1 as candidate gene for compounds related to boar taint

(2015) Christiane Neuhoff et al.   MEAT SCIENCE

FlyBase: establishing a Gene Group resource forDrosophila melanogaster

(2015) Helen Attrill et al.   NUCLEIC ACIDS RESEARCH

TMAO: A small molecule of great expectations

(2015) Marcin Ufnal et al.   NUTRITION

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

(2015) S. F. Leiser et al.   SCIENCE

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Why Is Aging Conserved and What Can We Do about It?

(2015) Jason N. Pitt et al.   PLOS BIOLOGY

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans

(2015) Devon Chandler-Brown et al.   Frontiers in Genetics

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases

(2015) Maria Laura Mascotti et al.   PLoS One

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance

(2014) Sunil Veeravalli et al.   BIOCHEMICAL PHARMACOLOGY

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide

(2014) Lisbeth K. Siddens et al.   BIOCHEMICAL PHARMACOLOGY

Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats

(2014) Marcin Ufnal et al.   CANADIAN JOURNAL OF CARDIOLOGY

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism

(2014) Boyu Li et al.   NEUROSCIENCE LETTERS

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Flavin dependent monooxygenases

(2013) Mieke M.E. Huijbers et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

(2013) Masaharu Uno et al.   Cell Reports

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects

(2012) Derrek P. Hibar et al.   Brain Imaging and Behavior

Converging Evidence of Mitochondrial Dysfunction in a Yeast Model of Homocysteine Metabolism Imbalance

(2011) Arun Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional analysis of bacterial flavin-containing monooxygenase reveals its ping-pong-type reaction mechanism

(2011) Hyo Je Cho et al.   JOURNAL OF STRUCTURAL BIOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

The main auxin biosynthesis pathway in Arabidopsis

(2011) K. Mashiguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans

(2010) Moon Cheol Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases

(2010) C. Gibrat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Flavin-containing monooxygenase-3: Induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver

(2010) Trine Celius et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment

(2009) Rachel M. Novick et al.   BIOCHEMICAL PHARMACOLOGY

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases

(2009) Da Cheng Hao et al.   GENETICA

Transcriptional Regulation of Metabolism Associated With the Increased Desiccation Resistance of the Cactophilic Drosophila mojavensis

(2009) Luciano M. Matzkin et al.   GENETICS

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein β (C/EBPβ) liver inhibitory and liver activating proteins

(2008) David E. Klick et al.   BIOCHEMICAL PHARMACOLOGY

Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver

(2008) T. Celius et al.   DRUG METABOLISM AND DISPOSITION

Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models

(2008) J. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

Altered Metabolism of Growth Hormone Receptor Mutant Mice: A Combined NMR Metabonomics and Microarray Study

(2008) Horst Joachim Schirra et al.   PLoS One

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase

(2008) A. Alfieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

(2007) Matthew J. Brauer et al.   MOLECULAR BIOLOGY OF THE CELL