Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease

Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

(2019) Josef Coresh et al.   Lancet Diabetes & Endocrinology

Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

(2019) Hiddo J L Heerspink et al.   Lancet Diabetes & Endocrinology

The Global Burden of Diabetic Kidney Disease: Time Trends and Gender Gaps

(2019) Bernadette Thomas   Current Diabetes Reports

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

(2019) Hiddo J L Heerspink et al.   LANCET

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

1924-P: Praliciguat, a Clinical-Stage sGC Stimulator, Improves Insulin Sensitivity, Lipid Tolerance, and Energy Utilization in a Mouse Diet-Induced Obesity Model Housed at Thermoneutrality

(2019) CHAD SCHWARTZKOPF et al.   DIABETES

Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE–TIMI 58 randomised trial

(2019) Ofri Mosenzon et al.   Lancet Diabetes & Endocrinology

An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

(2019) John P. Hanrahan et al.   DIABETOLOGIA

Praliciguat, a Clinical-Stage sGC Stimulator, Improved Glucose Tolerance and Insulin Sensitivity and Lowered Triglycerides in a Mouse Diet-Induced Obesity Model

(2018) CHAD D. SCHWARTZKOPF et al.   DIABETES

The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective

(2018) Shalini Krishnan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

(2018) Jenny V. Tobin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

(2018) E.S. Buys et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

(2018) Katherine R Tuttle et al.   Lancet Diabetes & Endocrinology

Liraglutide and Renal Outcomes in Type 2 Diabetes

(2017) Johannes F.E. Mann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis

(2017) Elisabeth Schinner et al.   FEBS Open Bio

Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial

(2017) David Z I Cherney et al.   Lancet Diabetes & Endocrinology

Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014

(2016) Maryam Afkarian et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy

(2016) W. Scheele et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2015) Johannes-Peter Stasch et al.   CURRENT OPINION IN PHARMACOLOGY

ENOS deficiency causes podocyte injury with mitochondrial abnormality

(2015) Shuko Ueda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevalence and Prognostic Significance of Apparent Treatment Resistant Hypertension in Chronic Kidney Disease

(2015) George Thomas et al.   HYPERTENSION

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

(2015) George L. Bakris et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diabetic kidney disease: a clinical update from Kidney Disease: Improving Global Outcomes

(2015) Mark E. Molitch et al.   KIDNEY INTERNATIONAL

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

(2015) Linda S. Hoffmann et al.   Nature Communications

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

(2014) Katherine R. Tuttle et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

(2014) Andrew S. Levey et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Nitric oxide in the normal kidney and in patients with diabetic nephropathy

(2014) Paolo Tessari   JOURNAL OF NEPHROLOGY

Nitric oxide system and diabetic nephropathy

(2014) Bruno Dellamea et al.   Diabetology & Metabolic Syndrome

Regulation of metabolism by cGMP

(2013) Alexander Pfeifer et al.   PHARMACOLOGY & THERAPEUTICS

Temporal Trends in the Prevalence of Diabetic Kidney Disease in the United States

(2011) Ian H. de Boer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function

(2011) Frank A. Holtkamp et al.   KIDNEY INTERNATIONAL

A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy

(2010) Zhen Zeng et al.   HUMAN GENETICS

Endothelial dysfunction as a potential contributor in diabetic nephropathy

(2010) Takahiko Nakagawa et al.   Nature Reviews Nephrology