Article
Pharmacology & Pharmacy
Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones
Summary: Praliciguat treatment showed metabolic effects of increasing energy utilization, improving insulin sensitivity, and reducing plasma triglycerides in diet-induced obesity (DIO) mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yuki Endo, Michihiro Hashimoto, Tatsuya Kusudo, Tadashi Okada, Tamaki Takeuchi, Ayumi Goto, Hitoshi Yamashita
Summary: CREG1 stimulates thermogenic fat formation and reduces diet-induced obesity. The study found that under conditions that attenuate thermogenic fat formation, administration of recombinant CREG1 protein increased UCP1 expression and inhibited fat hypertrophy, leading to reduced obesity. Additionally, UCP1 plays an indispensable role in the inhibitory effect of CREG1 on diet-induced obesity.
Article
Pharmacology & Pharmacy
Olga Gawrys, Zuzana Huskova, Petra Skaroupkova, Zuzana Honetschlagerova, Zdenka Vanourkova, Sona Kikerlova, Vojtech Melenovsky, Barbara Szeiffova Bacova, Matus Sykora, Milos Taborsky, Ludek Cervenka
Summary: Heart failure is a global pandemic with ineffective current therapies, especially in patients with cardio-renal syndrome. This study investigated the effectiveness of sGC stimulator for treating heart failure with cardio-renal syndrome using a rat model. Results showed that sGC stimulator increased the survival rate of rats with heart failure and improved cGMP excretion. This suggests that sGC stimulators could be a valuable class of drugs for treating heart failure with cardio-renal syndrome, but further studies are needed.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Sztolsztener, Karolina Konstantynowicz-Nowicka, Ewa Harasim-Symbor, Adrian Chabowski
Summary: The study revealed that a high-fat diet can enhance hepatic ceramide deposition by affecting selected proteins from sphingomyelin and salvage pathways. The changes in insulin signaling pathway, including inhibition of Akt phosphorylation and stimulation of PTEN and mTOR phosphorylation, worsened in a time-dependent manner, possibly due to excessive accumulation of sphingosine and sphinganine rather than ceramide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Lokesh Verma, Pawandeep Singh Kohli, Kanika Maurya, K. Abhijith, Jitendra K. Thakur, Jitender Giri
Summary: This study found that different rice genotypes show lipid remodeling under phosphorus deficiency, and specific galactolipid species correlate with phosphorus use efficiency in rice genotypes under P deficiency. The research reveals the importance of specific galactolipid species in rice adaptation to phosphorus-deficient soils.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Mingxiao Che, Ziye Lu, Liang Liu, Ning Li, Lina Ren, Shuyan Chi
Summary: This study evaluated the influence of dietary lysophospholipids combined with 1% fish oil reduction on the growth and hepatic lipid metabolism of largemouth bass. The results showed that adding 0.1% lysophospholipids to the diet improved digestive enzyme activity, growth performance, and liver enzyme activity in largemouth bass.
Article
Medicine, Research & Experimental
Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Kolawole A. Olofinsan, Sunday O. Oyedemi, Chika I. Chukwuma, Adeline Lum Nde, Md. Shahidul Islam
Summary: Reduced glucose uptake and utilization has been linked to obesity and its complications. This study found that cannabinoid-stimulated glucose uptake increased antioxidative activities, modulated cholinergic and purinergic dysfunctions, and improved glucose-lipid homeostasis in adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Wenjie Zhang, Bowen Shi, Shirui Li, Zenglin Liu, Songhan Li, Shuohui Dong, Yugang Cheng, Jiankang Zhu, Guangyong Zhang, Mingwei Zhong
Summary: This study found that sleeve gastrectomy (SG) can downregulate the deubiquitinase ubiquitin-specific peptidase 20 (USP20), thereby improving lipid metabolism abnormalities. Further investigation revealed that USP20 targets and stabilizes heat-shock protein family A member 2 (HSPA2) through the ubiquitin-proteasome pathway, promoting lipid accumulation. This suggests that the USP20-HSPA2 axis could be a noninvasive therapeutic target for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jiahua Zhu, Fan Zhang, Yuxing Huang, Jingyu Pan, Erchao Li, Jian G. Qin, Liqiao Chen, Xiaodan Wang
Summary: This research explores the influence of myo-inositol on the hypertonic stress adaptation of Nile tilapia by increasing lipid utilization and improving osmotic regulation ability. It was found that myo-inositol supplementation improved growth performance, promoted protein deposition, reduced fat accumulation, and alleviated liver lipid accumulation. Additionally, it reduced serum lipids and upregulated the expression of ion transporter-related genes. The findings suggest that dietary supplementation with myo-inositol can regulate lipid metabolism and improve the physiological response of Nile tilapia to hypertonic stress.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Gil Zandani, Sarit Anavi-Cohen, Tamar Yudelevich, Abraham Nyska, Nativ Dudai, Zecharia Madar, Jonathan Gorelick
Summary: This study found that supplementing high-fat diet with C. iphionoides can improve metabolic effects in a NAFLD model. Consumption of C. iphionoides can reduce weight gain, liver and adipose tissue weights, and improve liver function and lipid metabolism.
Article
Nutrition & Dietetics
Jiapeng Huang, Takashi Tagawa, Sihui Ma, Katsuhiko Suzuki
Summary: The study found that a single administration of black ginger extract (KPE) can significantly prolong the endurance time of mice, possibly through promoting cellular energy metabolism and substrate utilization.
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Article
Biochemical Research Methods
Feng Xu, Xiangpei Wang, Xiujuan Wei, Teng Chen, Hongmei Wu
Summary: This study explored the active ingredients and molecular mechanism of Musa basjoo pseudostem juice (MBSJ) against diabetes. The results showed that MBSJ exhibited good anti-diabetic activity, and the small-polar parts of MBSJ were rich in anti-diabetic active ingredients. Furthermore, the anti-diabetic effect of MBSJ may be the result of multiple components, multiple targets, and multiple pathways.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Endocrinology & Metabolism
Hai P. Nguyen, Sneha Damal Villivalam, Byung Chul Jung, Dongjoo You, Frances Lin, Danielle Yi, Anna Pi, Katherine Ma, Sunhee Jung, Sang-Hee Park, Cholsoon Jang, Hei Sook Sul, Sona Kang
Summary: AIFM2 is selectively induced in glycolytic muscles during exercise, and overexpression of AIFM2 increases glucose utilization through elevated NAD(+)-NADH ratio. Depletion of Aifm2 in muscles decreases exercise capacity and glucose utilization, while introduction of NDE1 ameliorates these impairments.
Article
Biology
Xue Liu, Ahmed Elagamy Mohamed Mahmoud Khalil, Uthayakumar Muthukumarasamy, Yasuhiro Onogi, Xiaocheng Yan, Inderjeet Singh, Elena Lopez-Gonzales, Andreas Israel, Alberto Cebrian Serrano, Till Strowig, Siegfried Ussar
Summary: Moderate telomere shortening improves insulin sensitivity and glucose tolerance in aged mice by reducing intestinal lipid absorption and altering gut microbiota composition.
