An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

From molecules to patients: exploring the therapeutic role of soluble guanylate cyclase stimulators

(2018) Peter Sandner   BIOLOGICAL CHEMISTRY

Praliciguat, a Clinical-Stage sGC Stimulator, Improved Glucose Tolerance and Insulin Sensitivity and Lowered Triglycerides in a Mouse Diet-Induced Obesity Model

(2018) CHAD D. SCHWARTZKOPF et al.   DIABETES

Association of endothelial dysfunction with cardiovascular risk factors and new-onset diabetes mellitus in patients with hypertension

(2018) Cristina Bergmann Triches et al.   Journal of Clinical Hypertension

Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

(2018) Jenny V. Tobin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

(2018) E.S. Buys et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study

(2017) Edward Yu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator

(2017) Xinni Xie et al.   Frontiers in Pharmacology

Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance

(2017) Yu Mi Kang et al.   Diabetes & Metabolism Journal

Integrative Control of Gastrointestinal Motility by Nitric Oxide

(2016) Dieter Groneberg et al.   CURRENT MEDICINAL CHEMISTRY

Gasotransmitters in Vascular Complications of Diabetes

(2016) Joost C. van den Born et al.   DIABETES

Asymmetric and Symmetric Dimethylarginine as Risk Markers for Total Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies

(2016) Sabrina Schlesinger et al.   PLoS One

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism

(2015) Tom Ashmore et al.   BMC BIOLOGY

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

(2015) Linda S. Hoffmann et al.   Nature Communications

Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance

(2014) Andrew M. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of metabolism by cGMP

(2013) Alexander Pfeifer et al.   PHARMACOLOGY & THERAPEUTICS

Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma

(2013) Emmanuel S. Buys et al.   PLoS One

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel roles of cAMP/cGMP-dependent signaling in platelets

(2011) A. SMOLENSKI   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role of asymmetric and symmetric dimethylarginines in renal disease

(2011) Edzard Schwedhelm et al.   Nature Reviews Nephrology

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans

(2010) Vikas Kapil et al.   HYPERTENSION

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

(2010) Corey E. Tabit et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Assessment of Vascular Endothelial Function With Peripheral Arterial Tonometry

(2009) Eshan A. Patvardhan et al.   Cardiology in Review