Article
Medicine, General & Internal
Nobuko Kitagawa, Noriyuki Kitagawa, Emi Ushigome, Hidetaka Ushigome, Isao Yokota, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: The study found that IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports, suggesting that IH-HSBP might be a useful marker in disease prognostication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
F. Jansson Sigfrids, E. H. Dahlstrom, C. Forsblom, N. Sandholm, V. Harjutsalo, M. -R. Taskinen, P. -H. Groop
Summary: Remnant cholesterol concentration, but not variability, predicts the progression of diabetic nephropathy and development of severe diabetic retinopathy in patients with type 1 diabetes. However, the causal relationship between remnant cholesterol and these outcomes remains to be elucidated.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Article
Biochemistry & Molecular Biology
Tilman Pfeffer, Charlotte Wetzel, Philip Kirschner, Maria Bartosova, Tanja Poth, Constantin Schwab, Gernot Poschet, Johanna Zemva, Ruben Bulkescher, Ivan Damgov, Christian Thiel, Sven F. F. Garbade, Kristina Klingbeil, Verena Peters, Claus Peter Schmitt
Summary: Supplementation of carnosine and anserine can effectively reduce diabetic nephropathy in rodents. However, the exact mechanism of their nephroprotective action in diabetes, whether it is through local protection or improved systemic glucose homeostasis, remains uncertain.
Article
Biochemistry & Molecular Biology
Shokichi Naito, Kenichi Nakayama, Nagako Kawashima
Summary: We found that albuminuria levels in patients with MCD and FSGS are negatively correlated with GM3 expression in glomerular podocytes. Activating GM3 synthesis through VPA administration suppresses albuminuria and podocyte injury. In diabetic nephropathy, enhanced GM3 expression via VPA decreases albuminuria, glomerular lesions, loss of podocytes, and expansion in the mesangial area. The therapeutic effect of maintaining GM3 expression may extend to late-stage diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Bruno Verges, Laurence Duvillard, Jean Paul Pais de Barros, Benjamin Bouillet, Sabine Baillot-Rudoni, Alexia Rouland, Jean Michel Petit, Pascal Degrace, Laurent Demizieux
Summary: The study showed that treatment with liraglutide significantly reduced plasma apoB100 and fasting triglyceride levels in patients with T2D, while also increasing the metabolism of triglyceride-rich lipoproteins and LDL. Liraglutide was found to modify gene expression related to apoB100-containing lipoprotein catabolism, potentially reducing cardiovascular risk in T2D patients.
Article
Medicine, General & Internal
Cheng-Hung Lee, Chia- Tsai, Yi-Chang Su, Shih-Yi Lin, I-Te Lee, Tsai-Chung Li
Summary: This study found that body constitution independently predicts new-onset albuminuria in individuals with type 2 diabetes. Yin deficiency and phlegm stasis are associated with an increased risk of albuminuria, and this relationship is influenced by glucose control status.
Review
Biology
Maria Chiara Pelle, Michele Provenzano, Marco Busutti, Clara Valentina Porcu, Isabella Zaffina, Lucia Stanga, Franco Arturi
Summary: Diabetes is a leading cause of kidney disease, specifically diabetic kidney disease (DKD) which is associated with increased cardiovascular risk. Chronic hyperglycemia and high blood pressure are risk factors for DKD, but blockade of the renin-angiotensin-aldosterone system can improve glomerular function and cardiovascular risk. New antidiabetic drugs have shown promise in delaying kidney disease progression and improving cardiovascular outcomes.
Article
Urology & Nephrology
Takaya Sasaki, Kaneyasu Nakagawa, Jun Hata, Yoichiro Hirakawa, Mao Shibata, Toshiaki Nakano, Nobuo Tsuboi, Yoshinao Oda, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study revealed a positive association between urinary albumin-creatinine ratio levels and the presence of class IIa or higher glomerular diabetic nephropathy (DN) lesions, even in individuals with normoalbuminuria. This suggests that DN lesions can exist in diabetic patients with normal albuminuria levels.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Shuoning Fan, Xueke Yang, Yingrui Yang, Zhijie Li
Summary: This study aims to explore the relationship between abnormal renal and liver function and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The study found that higher urine albumin and urine albumin/creatinine ratio were closely related to the occurrence of DR, and low total protein was associated with an increased risk of DR. The risk factor score was positively correlated with the risk of developing DR.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhou Zhou, Xue-qi Liu, Shi-qi Zhang, Xiang-ming Qi, Qiu Zhang, Benito Yard, Yong-gui Wu
Summary: Our study found that serum CN-1 concentration and activity were highest in patients with diabetic nephropathy (DN), while serum carnosine concentration was lowest. Furthermore, serum CN-1 concentration was positively correlated with uric acid and serum creatinine, and negatively correlated with serum albumin and estimated glomerular filtration rate within the DN group. Additionally, serum CN-1 concentration was positively correlated with various indicators of renal damage, suggesting its importance in the occurrence and progression of DN.
Article
Endocrinology & Metabolism
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Moller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
Summary: The study found that hypoxemia is associated with increased prevalence of albuminuria, retinopathy, and neuropathy in type 1 diabetes, but not with cardiovascular disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Wai Kin Chan, Sung-Sheng Tsai, Yan-Rong Li, Wei-Yu Chou, Hsiao-Lien Chen, Szu-Tah Chen
Summary: The study investigated the association between serum bilirubin levels and albuminuria progression in type 2 diabetic Taiwanese, finding that higher levels of serum BIL were associated with a lower risk of albuminuria progression.
BIOMEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Marwa Mohsen, Ahmed A. Elberry, Alaa Mohamed Rabea, Mohamed E. A. Abdelrahim, Raghda R. S. Hussein
Summary: The prevalence of diabetes mellitus has increased, leading to complications such as cardiovascular diseases and diabetic kidney disease. Current recommendations for the management of diabetic nephropathy focus on glycemic and blood pressure control, as well as the use of renin-angiotensin system blockade. New agents with nephroprotective effects beyond lowering blood sugar have been clinically validated.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Yongliang Liu, Dayu Xu, Linping Wang, Wenyan Du, Limei Zhang, Xinxin Xiang
Summary: The expression of MBTPS2 is upregulated in the renal cortex of diabetic mice, and its overexpression exacerbates albuminuria while knockdown attenuates it. Furthermore, MBTPS2 promotes ER stress and renal damage, which can be significantly rescued by reducing ER stress with 4-PBA.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Rheumatology
A. Tocoian, P. Buchan, H. Kirby, J. Soranson, M. Zamacona, R. Walley, N. Mitchell, E. Esfandiari, F. Wagner, R. Oliver
Article
Pharmacology & Pharmacy
Timothy Mutsvari, Dominique Tytgat, Rosalind Walley
PHARMACEUTICAL STATISTICS
(2016)
Article
Pharmacology & Pharmacy
Rosalind J. Walley, Claire L. Smith, Jeremy D. Gale, Phil Woodward
PHARMACEUTICAL STATISTICS
(2015)
Article
Pharmacology & Pharmacy
Rosalind Walley, John Sherington, Joe Rastrick, Eric Detrait, Etienne Hanon, Gillian Watt
PHARMACEUTICAL STATISTICS
(2016)
Review
Obstetrics & Gynecology
Nick Pullen, Claire L. Birch, Garry J. Douglas, Qasim Hussain, Ingrid Pruimboom-Brees, Rosalind J. Walley
HUMAN REPRODUCTION UPDATE
(2011)
Article
Public, Environmental & Occupational Health
Jeremy D. Jokinen, Rosalind J. Walley, Michael W. Colopy, Thomas S. Hilzinger, Peter Verdru
Article
Medical Informatics
Jessica Lim, Li Wang, Nicky Best, Jeen Liu, Jiacheng Yuan, Florence Yong, Lanju Zhang, Rosalind Walley, Alice Gosselin, Robert Roebling, Kert Viele
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2020)
Review
Medical Informatics
Yodit Seifu, Margaret Gamalo-Siebers, Friederike M-S Barthel, Junjing Lin, Junshan Qiu, Freda Cooner, Shiling Ruan, Rosalind Walley
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2020)
Article
Pharmacology & Pharmacy
Rosalind J. Walley, Andrew P. Grieve
Summary: For any decision-making study, it is important to consider the trade-off between type I and II error rates, as well as the context and prior beliefs of the study. When resources are limited, optimizing this trade-off becomes crucial, especially in the case of planned Bayesian statistical analysis.
PHARMACEUTICAL STATISTICS
(2021)
Article
Pharmacology & Pharmacy
Rosalind Walley, Nigel Brayshaw
Summary: Successful innovation in industry involves both developing new statistical methodology and ensuring its successful implementation by enabling applied statisticians to understand and implement the new method. Advocacy and influencing stakeholders are key to gaining acceptance for the new methodology.
PHARMACEUTICAL STATISTICS
(2022)
Article
Chemistry, Medicinal
Siew Kuen Yeap, Rosalind J. Walley, Mike Snarey, Willem P. van Hoorn, Jonathan S. Mason
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2007)
Article
Multidisciplinary Sciences
TA Clayton, JC Lindon, O Cloarec, H Antti, C Charuel, G Hanton, JP Provost, JL Le Net, D Baker, RJ Walley, JR Everett, JK Nicholson
Review
Mathematical & Computational Biology
CJ Weir, RJ Walley
STATISTICS IN MEDICINE
(2006)
Article
Biochemical Research Methods
Sally-Ann Fancy, Olaf Beckonert, Gareth Darbon, Warren Yabsley, Rosalind Walley, David Baker, George L. Perkins, Frank S. Pullen, Klaus Rumpel
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2006)