Principles of Self-Organization of the Mammalian Embryo

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

(2020) Shruti Singla et al.   Nature Communications

Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

(2020) Nestor Saiz et al.   eLife

Keratins are asymmetrically inherited fate determinants in the mammalian embryo

(2020) Hui Yi Grace Lim et al.   NATURE

Hydraulic control of mammalian embryo size and cell fate

(2019) Chii Jou Chan et al.   NATURE

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst

(2019) Julien G. Dumortier et al.   SCIENCE

TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage

(2019) Tristan Frum et al.   DEVELOPMENT

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

(2019) Ronghui Li et al.   CELL

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

(2019) Madeleine Linneberg-Agerholm et al.   DEVELOPMENT

A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst

(2019) Ritsuya Niwayama et al.   DEVELOPMENTAL CELL

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

(2019) Berna Sozen et al.   DEVELOPMENTAL CELL

Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation

(2019) Allyson Quinn Ryan et al.   DEVELOPMENTAL CELL

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Symmetry Breaking in the Mammalian Embryo

(2018) Hui Ting Zhang et al.   Annual Review of Cell and Developmental Biology

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development

(2018) Anna Hupalowska et al.   CELL

Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos

(2018) Jiaqiang Wang et al.   CELL

HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo

(2018) Tristan Frum et al.   eLife

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

(2017) Meng Zhu et al.   Nature Communications

Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

(2017) Eszter Posfai et al.   eLife

Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway

(2017) M. Wigger et al.   Scientific Reports

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

(2016) Mubeen Goolam et al.   CELL

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo

(2016) Maryna Panamarova et al.   DEVELOPMENT

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

(2016) Néstor Saiz et al.   Nature Communications

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

Next generation limb development and evolution: old questions, new perspectives

(2015) Aimée Zuniga   DEVELOPMENT

Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos

(2015) Yoshikazu Hirate et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

(2015) Chaminda R. Samarage et al.   DEVELOPMENTAL CELL

Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst

(2015) Panagiotis Xenopoulos et al.   Cell Reports

Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo

(2014) Shihadeh Anani et al.   DEVELOPMENT

Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network

(2014) S. Bessonnard et al.   DEVELOPMENT

Inhibition of RHO–ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst

(2014) Kanako Kono et al.   DEVELOPMENTAL BIOLOGY

GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst

(2014) Nadine Schrode et al.   DEVELOPMENTAL CELL

Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo

(2014) I. Bedzhov et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sox17-Mediated XEN Cell Conversion Identifies Dynamic Networks Controlling Cell-Fate Decisions in Embryo-Derived Stem Cells

(2014) Angela C.H. McDonald et al.   Cell Reports

HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst

(2014) Eryn Wicklow et al.   PLoS Genetics

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst

(2013) N. Saiz et al.   DEVELOPMENT

Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo

(2013) Nadine Schrode et al.   GENESIS

Asymmetric Localization of Cdx2 mRNA during the First Cell-Fate Decision in Early Mouse Development

(2013) Maria Skamagki et al.   Cell Reports

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos

(2013) S. A. Morris et al.   Open Biology

Generation and live imaging of an endogenous Cdx2 reporter mouse line

(2012) Katie McDole et al.   GENESIS

Developmental Plasticity Is Bound by Pluripotency and the Fgf and Wnt Signaling Pathways

(2012) Samantha A. Morris et al.   Cell Reports

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

The gap gene network

(2010) Johannes Jaeger   CELLULAR AND MOLECULAR LIFE SCIENCES

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

(2010) A. Ralston et al.   DEVELOPMENT

Epigenetic Modification Affecting Expression of Cell Polarity and Cell Fate Genes to Regulate Lineage Specification in the Early Mouse Embryo

(2010) David-Emlyn Parfitt et al.   MOLECULAR BIOLOGY OF THE CELL

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

(2010) S. A. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-regulation of the Nanog and Cdx2 promoters

(2009) Lingyi Chen et al.   CELL RESEARCH

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst

(2009) Sigolène M. Meilhac et al.   DEVELOPMENTAL BIOLOGY

Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions

(2008) M. Bischoff et al.   DEVELOPMENT

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

(2008) B. Plusa et al.   DEVELOPMENT

Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos

(2008) Aneta Suwińska et al.   DEVELOPMENTAL BIOLOGY

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

(2008) A. Jedrusik et al.   GENES & DEVELOPMENT

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE